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Effect of Curcumin Supplementation on Symptoms of Anxiety: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Fathi S1 ; Agharloo S1 ; Falahatzadeh M2 ; Bahraminavid S3 ; Homayooni A4 ; Faghfouri AH5 ; Shafiei D6 ; Shafagh SG7
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Medicine, Tonekabon Medical Sciences Branch, Islamic Azad University, Tonekabon, Iran
  4. 4. Universita Cattolica del Sacro Cuore, Medicine and Surgery, Rome, Italy
  5. 5. Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran
  6. 6. Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Faculty of Medicine, Iran University of Medical Sciences(IUMS), Tehran, Iran

Source: Clinical Nutrition ESPEN Published:2024


Abstract

Background and aim: Curcumin is a polyphenolic natural compound that has been used to treat various ailments such as symptoms of anxiety. However, the findings of studies regarding the anti-anxiety properties of curcumin are controversial. This review aims to evaluate if there are clinical benefits of curcumin in patients with symptoms of anxiety. Methods: PubMed, Embase, Web of Science, and the Cochrane Library were retrieved to collect randomized controlled trials (RCTs) from the database inception to August 16, 2023. The random-effects model was used to estimate the standard mean difference (SMD). Results: A total of eight RCTs involving 567 participants were included in the analysis. A pooled analysis showed a significant effect of curcumin on anxiety symptoms (SMD: −1.56; 95% CI: −2.48, −0.64, p < 0.001; I2 = 95.6%, p-heterogeneity< 0.001). Conclusion: Present meta-analysis demonstrated that curcumin intake might contribute to alleviation of anxiety disorder. Due to the limited number of studies included, it is necessary to conduct more high-quality studies to confirm the clinical efficacy of curcumin. © 2024 European Society for Clinical Nutrition and Metabolism
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