Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Determination of Biofilm Formation Ability and Antibiotic Resistance of Acinetobacter Baumannii Strains Isolated From Patients With Burn Wound Infection Publisher



Haghighifar E1 ; Nasresfahani B1 ; Fazeli H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Bacteriology and Virology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2017


Abstract

Background: Acinetobacter baumannii (A. baumannii) is an opportunistic pathogen with high antibiotic resistance and biofilm production capability in the patients with burn wound. The present study aimed to determine the antibiotic resistance pattern and frequency of the multidrug-resistant (MDR) strains, and evaluate biofilm formation potential in the burn wound infection isolates. Methods: Biochemical and molecular tests were used for identification of the 117 strains collected from Isfahan City, Iran, during one-year period. Antibacterial susceptibility test was performed using disk diffusion and interpreted in accordance with the standards of Clinical and Laboratory Standards Institute (CLSI). Biofilm formation was evaluated using microtiter plate assay. Findings: Of 117 clinical strains of A. baumannii, 114 (97.49%) were MDR. Strains showed maximum resistant to ceftazidime (99.14%) followed by ciprofloxacin (94.01%). 81.19% of isolates were able to form biofilm, 1.7% of strains were strong-biofilm producers, and 18.80% of them were notable biofilm producers. In this assessment, 42.73% and 36.75% were considered as moderate and weak biofilm-forming isolates, respectively. Conclusion: The high prevalence of A. baumannii in patients with burn wound, and the significant relationship between biofilm formation and resistance among the burn isolates indicate that antibiotic resistance is increasing rapidly, and soon many usable antibiotics will become ineffective medicines for treating patients. This needs an emergency actions and alternative ways to control these problems. © 2017 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Molecular Detection of Type Ii Toxin-Antitoxin Systems and Their Association With Antibiotic Resistance and Biofilm Formation in Clinical Acinetobacter Baumannii Isolates of Burn Patients, Journal of Mazandaran University of Medical Sciences (2021)
2. Detection of Genes Involved in Biofilm Formation in Mdr and Xdr Acinetobacter Baumannii Isolated From Human Clinical Specimens in Isfahan, Iran, Archives of Clinical Infectious Diseases (2019)
3. Prevalence of Blaveb and Blatem Genes, Antimicrobial Resistance Pattern and Biofilm Formation in Clinical Isolates of Pseudomonas Aeruginosa From Burn Patients in Isfahan, Iran, Gene Reports (2021)
4. Bacterial Infections and Antimicrobial Resistance Patterns of Burn Wound Infections: A One Year Study From Burn Hospital, Isfahan, Iran, Journal of Advances in Medical and Biomedical Research (2020)
5. Prevalence of Blatem and Blaveb Genes in Multidrug-Resistant Acinetobacter Baumannii Strains Isolated From Burn Wound Infection in Isfahan, Iran, Infection, Epidemiology and Microbiology (2020)
6. Molecular Characterization of Acinetobacter Baumannii Isolated From Ventilator-Associated Pneumonia and Burn Wound Colonization by Random Amplified Polymorphic Dna Polymerase Chain Reaction and the Relationship Between Antibiotic Susceptibility and Biofilm Production, Advanced Biomedical Research (2019)
7. Determination of Antibiotic Resistance Pattern and Prevalence of Oxa-Type Carbapenemases Among Acinetobacter Baumannii Clinical Isolates From Inpatients in Isfahan, Central Iran, Infezioni in Medicina (2018)
8. Prevalence of Metallo-Beta-Lactamase Producing Acinetobacter Baumannii Isolated From Intensive Care Unit in Tertiary Care Hospitals, Annali di Igiene Medicina Preventiva e di Comunita (2018)
Experts (# of related papers)
View all Related Experts
Hossein Fazeli (33)
Bahram Nasr Esfahani (24)
Other Related Docs
9. Investigation of Carbapenem Resistant Acinetobacter Baumannii St2 in Iran, Acta Microbiologica et Immunologica Hungarica (2021)
10. Resistance to Colistin and Detection of Mcr-1 Gene in Multidrug-Resistant Pseudomonas Aeruginosa Isolated From Wounds of the Hospitalized Burned Patients, Journal of Isfahan Medical School (2022)
11. Frequency of Metallo-Β-Lactamase and Antimicrobial Resistance Patterns of Acinetobacter Baumannii in Carbapenem-Resistant Isolates in Intensive Care Units, Journal of Isfahan Medical School (2015)
12. Frequency of Multi-Drug Resistance Acinetobacter Baumannii Isolates in Intensive Care Units (Icu) of Isfahan Hospitals, Iran, Via Molecular Method and Their Antimicrobial Resistance Patterns, Journal of Isfahan Medical School (2014)
13. Characterization of Oxacillinase and Metallo-Β-Lactamas Genes and Molecular Typing of Clinical Isolates of Acinetobacter Baumannii in Ahvaz, South-West of Iran, Jundishapur Journal of Microbiology (2016)
14. Emergence of Carbapenem Resistant Acinetobacter Baumannii Clonal Complexes Cc2 and Cc10 Among Fecal Carriages in an Educational Hospital, International Journal of Environmental Health Research (2022)
15. Identification and Frequency of Colistin-Resistant Acintobacter Baumanii in Clinical Isolates Using Polymerase Chain Reaction, Journal of Isfahan Medical School (2014)
16. Frequency and Resistance Patterns of Bacterial Isolates From Burn Wounds Infections in Isfahan, Iran, Journal of Isfahan Medical School (2013)
17. Efficacy of Isolated Bacteriophage Against Biofilm Embedded Colistin-Resistant Acinetobacter Baumannii, Gene Reports (2021)
18. Detection of Efflux Pump Genes in Multiresistant Acinetobacter Baumannii St2 in Iran, Acta Microbiologica et Immunologica Hungarica (2021)
19. Dissemination of Carbapenem-Resistant Acinetobacter Baumannii in Patients With Burn Injuries, Journal of the Chinese Medical Association (2017)
20. Molecular Evaluation of Colistin-Resistant Gene Expression Changes in Acinetobacter Baumannii With Real-Time Polymerase Chain Reaction, Infection and Drug Resistance (2017)
21. Detection of Antibiotic Resistant Acinetobacter Baumannii in Various Hospital Environments: Potential Sources for Transmission of Acinetobacter Infections, Environmental Health and Preventive Medicine (2017)
22. Different Virulence Capabilities and Ompa Expressions in St2 and St513 of Multidrug-Resistant Acinetobacter Baumannii, Current Microbiology (2019)
23. Plasmid Mediated Antibiotic Resistance in Isolated Bacteria From Burned Patients, Jundishapur Journal of Microbiology (2015)
24. Antibacterial Resistance Patterns of Acinetobacter Baumannii Complex: The Results of Isfahan Antimicrobial Resistance Surveillance-1 Program, Asian Pacific Journal of Tropical Medicine (2021)
25. Investigation of Class I, Ii, and Iii Integrons Among Acinetobacter Baumannii Isolates From Hospitalized Patients in Isfahan, Iran, Oman Medical Journal (2018)
26. High Prevalence of Multidrug Resistance and Metallo-Beta-Lactamase (Mβl) Producing Acinetobacter Baumanniiisolated From Patients in Icu Wards, Hamadan, Iran, Journal of Research in Health Sciences (2013)
27. Identification of Blaoxa−51−23−58, Blavim, Blandm, and Blaimp Carbapenemase Genes in Acinetobacter Baumannii Isolates From Hospitalized Patients, BMC Research Notes (2024)
28. Detection of Icaad Gene and Biofilm Formation in Staphylococcus Aureus Isolates From Wound Infections, Iranian Journal of Public Health (2006)
29. In Vitro Synergistic Effect of Colistin and Ampicillin/Sulbactam With Several Antibiotics Against Clinical Strains of Multi-Drug Resistant Acinetobacter Baumannii, Indian Journal of Medical Microbiology (2021)
30. Identification of Genomic Species Ofacinetobacter Isolated From Burns of Icu Patients, Archives of Iranian Medicine (2015)
31. Detection of Colistin Sensitivity in Clinical Isolates of Acinetobacter Baumannii in Iran, Journal of Research in Medical Sciences (2014)
32. Investigation of the Characteristics of Multidrug-Resistant (Mdr) Acinetobacter Baumannii Lytic Phage Isolated From the Intensive Care Unit, Journal of Isfahan Medical School (2019)
33. Emergence of Colistin Resistant Acinetobacter Baumannii Clonal Complex 2 (Cc2) Among Hospitalized Patients in Iran, Acta Microbiologica et Immunologica Hungarica (2023)
34. Identification of Beta-Lactamase-Producing Pseudomonas Aeruginosa With Multiple Antibiotic Resistances, Journal of Isfahan Medical School (2011)
35. Prevalence and Antibiotic Resistance Pattern of Acinetobacter Species Isolated From Al-Zahra Hospital in Isfahan, Iran, Journal of Isfahan Medical School (2013)
36. Evaluation of the Simultaneous Effects of Lactobacillus Delbrueckii and Lactobacillus Lactis on Biofilms of Isolates From Chronic Ulcer Infections With Multiple-Drug Resistance, Jundishapur Journal of Microbiology (2022)
37. Incidence of Co-Resistance to Antibiotics and Chlorine in Bacterial Biofilm of Hospital Water Systems: Insights Into the Risk of Nosocomial Infections, Journal of Infection and Public Health (2023)
38. Detection of Metallo-Beta Lactamases Among Carbapenem-Resistant Pseudomonas Aeruginosa, Jundishapur Journal of Microbiology (2014)
39. Morphological and Bactericidal Effects of Amikacin, Meropenem and Imipenem on Pseudomonas Aeruginosa, Jundishapur Journal of Microbiology (2015)
40. Molecular Analysis of Drug-Resistant Acinetobacter Baumannii Isolates by Eric-Pcr, Meta Gene (2018)
41. Global Sequence Analysis and Expression of Azurin Gene in Different Clinical Specimens of Burn Patients With Pseudomonas Aeruginosa Infection, Infection and Drug Resistance (2020)
42. Characterization of Clonal Groups of Antibiotic-Resistant Biofilm-Forming Staphylococcus Aureus Strains Isolated From Patients With Urinary Tract Infections in Isfahan, Iran, Archives of Clinical Infectious Diseases (2024)
43. Isolation of Bacteriophages Against Multidrug Resistant Acinetobacter Baumannii, Research in Pharmaceutical Sciences (2017)
44. Evaluation of Pseudomonas Aeroginosa Isolated From Cutaneous Infections and Determination of Drug Resistance Pattern in Patients of Alzahra Hospital in Esfahan, Journal of Isfahan Medical School (2010)
45. Investigating of Four Main Carbapenem-Resistance Mechanisms in High-Level Carbapenem Resistant Pseudomonas Aeruginosa Isolated From Burn Patients, Journal of the Chinese Medical Association (2018)
46. The Bacterial Biofilm Resistome in Drinking Water Distribution Systems: A Systematic Review, Chemosphere (2023)
47. Detection of Blactx-M15 and Blaoxa-48 Genes in Gram-Negative Isolates From Neonatal Sepsis in Central of Iran, Iranian Journal of Microbiology (2019)
48. Distribution of Sccmec Elements and Presence of Panton-Valentine Leukocidin in Methicillin-Resistant Staphylococcus Epidermidis Isolated From Clinical Samples in a University Hospital of Isfahan City, Iran, Journal of Clinical and Diagnostic Research (2017)
49. Prevalence and Antimicrobial Resistance of Bacterial Agents Isolated From the Cases of Dental Caries, International Tinnitus Journal (2023)
50. First Prevalence of Metallo Beta-Lactamases Producing Enterobacteriacea in Iranian Cancer Patients, Annali di Igiene Medicina Preventiva e di Comunita (2019)