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Dietary Choline and Betaine Intake, Cardio-Metabolic Risk Factors and Prevalence of Metabolic Syndrome Among Overweight and Obese Adults Publisher Pubmed



Abbasi MSP1 ; Tousi AZ2 ; Yazdani Y3 ; Vahdat S4 ; Gharebakhshi F5 ; Nikrad N6 ; Manzouri A7 ; Ardekani AM8 ; Jafarzadeh F9
Authors
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Authors Affiliations
  1. 1. Department of Cardiovascular Surgery, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran
  3. 3. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Isfahan Kidney Disease Research Center, School of Medicine, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Radiology, School of Medicne, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science, & Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
  9. 9. Department of Internal Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnourd, Iran

Source: BMC Endocrine Disorders Published:2023


Abstract

Background: Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine. There are numerous studies with inconsistent results that evaluated the association between dietary choline intakes with cardiovascular risk factors. In addition, the association between dietary betaine and choline intakes with cardio-metabolic risk factors is not well studied. In the current study, our aim was to evaluate dietary choline and betaine intakes in the usual diet of obese individuals and to assess its association with serum lipids, blood pressure and glycemic markers among obese individuals. Methods: We recruited a total number of 359 obese people aged between 20 and 50 years in the present study. A semi-quantitative food frequency questionnaire (FFQ) was used for dietary assessment; dietary choline and betaine intakes were calculated using the United States Department of Agriculture (USDA) database. National cholesterol education program adult treatment panel (NCEP-ATP)-III criteria was used metabolic syndrome (MetS) definition. Enzymatic methods were used to assess biochemical variables. Body composition was measured with the bioelectrical impedance analysis (BIA) method. Results: Higher body mass index (BMI), waist to hip ratio (WHR), fat-free mass (FFM) and basal metabolic rate (BMR) were observed in higher tertiles of dietary choline intake (P < 0.01). There was no significant difference in terms of biochemical parameters among different tertiles of dietary choline intake, while systolic blood pressure (SBP) and diastolic blood pressure (DBP) were reduced in higher betaine tertiles (P < 0.05). For total dietary choline and betaine intakes, there was a reduction in DBP and low density lipoprotein (LDL) concentrations (P < 0.05). Also, a non-significant reduction in serum total cholesterol (TC), triglyceride (TG) and MetS prevalence was observed in higher tertiles of dietary choline and betaine intakes. After classification of the study population according to MetS status, there was no significant difference in biochemical variables in subjects with MetS (P > 0.05), while in the non-MetS group, SBP, DBP, TG and insulin levels reduced in higher tertiles of dietary betaine and choline (P > 0.05). Conclusion: According to our findings, higher dietary intakes of choline and betaine were associated with lower levels of blood pressure and LDL concentrations among obese individuals. Further studies are warranted to confirm the results of the current study. © 2023, The Author(s).
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