Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Clinical Impact of Mrna Therapeutics in the Treatment of Cancers, Infections, Genetic Disorders, and Autoimmune Diseases Publisher



Deyhimfar R1, 2 ; Izady M1 ; Shoghi M3 ; Kazazi MH4 ; Ghazvini ZF5 ; Nazari H6 ; Fekrirad Z7, 8 ; Arefian E8, 9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Stem Cells Technology and Tissue Regeneration, School of Biology, College of Science, University of Tehran, Tehran, Iran
  2. 2. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biology, University of Copenhagen, Copenhagen, Denmark
  4. 4. Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, ON, Canada
  5. 5. Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran
  6. 6. School of Biomedical Engineering, University of Technology Sydney, Sydney, Australia
  7. 7. Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
  8. 8. Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran
  9. 9. Pediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Heliyon Published:2024


Abstract

mRNA-based therapeutics have revolutionized medicine and the pharmaceutical industry. The recent progress in the optimization and formulation of mRNAs has led to the development of a new therapeutic platform with a broad range of applications. With a growing body of evidence supporting the use of mRNA-based drugs for precision medicine and personalized treatments, including cancer immunotherapy, genetic disorders, and autoimmune diseases, this emerging technology offers a rapidly expanding category of therapeutic options. Furthermore, the development and deployment of mRNA vaccines have facilitated a prompt and flexible response to medical emergencies, exemplified by the COVID-19 outbreak. The establishment of stable and safe mRNA molecules carried by efficient delivery systems is now available through recent advances in molecular biology and nanotechnology. This review aims to elucidate the advancements in the clinical applications of mRNAs for addressing significant health-related challenges such as cancer, autoimmune diseases, genetic disorders, and infections and provide insights into the efficacy and safety of mRNA therapeutics in recent clinical trials. © 2024
Related Docs
View other Related Docs
1. Recent Developments in Sars-Cov-2 Vaccines: A Systematic Review of the Current Studies, Reviews in Medical Virology (2023)
2. Could Artificial Intelligence Revolutionize the Development of Nanovectors for Gene Therapy and Mrna Vaccines?, Nano Today (2022)
3. Dendritic Cell Vaccination Strategy for the Treatment of Acute Myeloid Leukemia: A Systematic Review, Cytotherapy (2024)
4. Characterization of Stability, Safety and Immunogenicity of the Mrna Lipid Nanoparticle Vaccine Iribovax® Against Covid-19 in Nonhuman Primates, Journal of Controlled Release (2023)
5. Covid-19 Vaccinations: The Unknowns, Challenges, and Hopes, Journal of Medical Virology (2022)
6. Immunologic Response, Efficacy, and Safety of Vaccines Against Covid-19 Infection in Healthy and Immunosuppressed Children and Adolescents Aged 2 – 21 Years Old: A Systematic Review and Meta-Analysis, Journal of Clinical Virology (2022)
7. Immunotherapy in Aml: A Brief Review on Emerging Strategies, Clinical and Translational Oncology (2021)
8. Charge Neutralized Poly(Β-Amino Ester) Polyplex Nanoparticles for Delivery of Self-Amplifying Rna, Nanoscale Advances (2024)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (16)
Mohammadreza Salehi (3)
Other Related Docs
9. Covid-19 Vaccines Cost-Effectiveness Analysis: A Scenario for Iran, Vaccines (2022)
10. Acute Ischemic Stroke and Vaccine-Induced Immune Thrombotic Thrombocytopenia Post Covid-19 Vaccination; a Systematic Review, Journal of the Neurological Sciences (2022)
11. Cutaneous Adverse Reactions Following Covid-19 Vaccinations: A Systematic Review and Meta-Analysis, Journal of Cosmetic Dermatology (2022)
12. Safety and Immunogenicity of Corenapcin, a Sars-Cov-2 Mrna Vaccine, As a Fourth Heterologous Booster in Healthy Iranian Adults: A Double-Blind, Randomized, Placebo-Controlled, Phase 1 Clinical Trial With a Six-Month Follow-Up, International Immunopharmacology (2024)
13. Nanotheranostics Against Covid-19: From Multivalent to Immune-Targeted Materials, Journal of Controlled Release (2020)
14. Sars-Cov-2: Current Trends in Emerging Variants, Pathogenesis, Immune Responses, Potential Therapeutic, and Vaccine Development Strategies, International Immunopharmacology (2021)
15. The Significance of Bioengineered Nanoplatforms Against Sars-Cov-2: From Detection to Genome Editing, Life Sciences (2021)
16. Recent Approaches to Mrna Vaccine Delivery by Lipid-Based Vectors Prepared by Continuous-Flow Microfluidic Devices, Future Medicinal Chemistry (2022)
17. Vlp-Based Covid-19 Vaccines: An Adaptable Technology Against the Threat of New Variants, Vaccines (2021)
18. Antibody Response Before and After the Booster Dose of Inactivated Corona Vaccine in Antibody Deficient Patients, Iranian Journal of Allergy# Asthma and Immunology (2024)
19. Biomimetic Nanotechnology for Cancer Immunotherapy: State of the Art and Future Perspective, International Journal of Pharmaceutics (2024)
20. Seroconversion Following the First, Second, and Third Dose of Sars-Cov-2 Vaccines in Immunocompromised Population: A Systematic Review and Meta-Analysis, Virology Journal (2022)
21. Therapeutic and Diagnostic Applications of Nanoparticles in the Management of Covid-19: A Comprehensive Overview, Virology Journal (2022)
22. Recent Advances in Glioma Cancer Treatment: Conventional and Epigenetic Realms, Vaccines (2022)
23. Delving Into Revolutionary Sars-Cov-2 Vaccine Approaches: Molecular and Virological Examinations; Principles of Sars-Cov-2 Vaccine Platform; [Adentrandose En Enfoques Revolucionarios De Vacunas Sars-Cov-2: Examenes Moleculares Y Virologicos; Principios De La Plataforma De Vacunas Sars-Cov-2], Vacunas (2024)
24. The Effectiveness of Covid-19 Vaccines in Reducing the Incidence, Hospitalization, and Mortality From Covid-19: A Systematic Review and Meta-Analysis, Frontiers in Public Health (2022)
25. Effectiveness of Covid-19 Vaccines Against Delta (B.1.617.2) Variant: A Systematic Review and Meta-Analysis of Clinical Studies, Vaccines (2022)
26. Safety and Immunogenicity of an Inactivated Virus Particle Vaccine for Sars-Cov-2, Biv1-Coviran: Findings From Double-Blind, Randomised, Placebo-Controlled, Phase I and Ii Clinical Trials Among Healthy Adults, BMJ Open (2022)
27. Tumor-Infiltrating Lymphocyte Therapy for Lung Cancer and Its Future Paradigms, Expert Opinion on Biological Therapy (2022)
28. Efficacy and Safety of an Inactivated Virus-Particle Vaccine for Sars-Cov-2, Biv1-Coviran: Randomised, Placebo Controlled, Double Blind, Multicentre, Phase 3 Clinical Trial, BMJ (2023)
29. Diagnostic Performance of a Novel Antigen-Capture Elisa for the Detection of Sars-Cov-2, Analytical Biochemistry (2023)
30. Induced Pluripotent Stem Cells: Generation Methods and a New Perspective in Covid-19 Research, Frontiers in Cell and Developmental Biology (2023)
31. Covid-19 Infection Risk Following Elective Arthroplasty and Surgical Complications in Covid-19-Vaccinated Patients: A Multicenter Comparative Cohort Study, Arthroplasty Today (2022)
32. Emerging Therapeutics and Delivery, Pharmaceutics: Basic Principles and Application to Pharmacy Practice# Second Edition (2023)
33. Chimeric Antigen Receptor-Natural Killer Cells: A Promising Sword Against Insidious Tumor Cells, Human Cell (2023)
34. An Updated Review of Interleukin-2 Therapy in Cancer and Autoimmune Diseases, Journal of Interferon and Cytokine Research (2024)
35. Breakthrough Sars-Cov-2 Infections After Vaccination: A Critical Review, Human Vaccines and Immunotherapeutics (2022)
36. Natural Killer Cells and Acute Myeloid Leukemia: Promises and Challenges, Cancer Immunology# Immunotherapy (2022)
37. The Effect of Covid-19 Mrna Vaccines Against Postvaccination Laboratory-Confirmed Sars-Cov-2 Infection, Symptomatic Covid-19 Infection, Hospitalization, and Mortality Rate: A Systematic Review and Meta-Analysis, Expert Review of Vaccines (2022)
38. Sars-Cov-2 Antibody Response After Bbibp-Corv (Sinopharm) Vaccination in Cancer Patients: A Case-Control Study, Frontiers in Medicine (2023)
39. Association of Sars-Cov-2 Vaccination or Infection With Bell Palsy: A Systematic Review and Meta-Analysis, JAMA Otolaryngology - Head and Neck Surgery (2023)
40. Novel Car T Therapy Is a Ray of Hope in the Treatment of Seriously Ill Aml Patients, Stem Cell Research and Therapy (2021)
41. State-Of-The-Art of Nanodiagnostics and Nanotherapeutics Against Sars-Cov-2, ACS Applied Materials and Interfaces (2021)
42. Unraveling the Complex Interactions Between the Fat Mass and Obesity-Associated (Fto) Gene, Lifestyle, and Cancer, Advances in Nutrition (2022)
43. The Potential Role of Immunotherapy in Wilms’ Tumor: Opportunities and Challenges, Current Pharmaceutical Design (2023)
44. Covid-19 Vaccine Boosters: The Good, the Bad, and the Ugly, Vaccines (2021)
45. Car-Engineered Nk Cells; a Promising Therapeutic Option for Treatment of Hematological Malignancies, Stem Cell Research and Therapy (2021)
46. An Alphavirus-Derived Self-Amplifying Mrna Encoding Ppsp15-Lmsti1 Fusion Protein for the Design of a Vaccine Against Leishmaniasis, Parasitology International (2022)
47. The Current Landscape of Car T-Cell Therapy for Solid Tumors: Mechanisms, Research Progress, Challenges, and Counterstrategies, Frontiers in Immunology (2023)
48. Sudden Sensorineural Hearing Loss After Receiving an Inactivated Viral Vaccine, Sinopharm: Two-Case Report, SAGE Open Medical Case Reports (2023)
49. The Quest for a Better Fight: How Can Nanomaterials Address the Current Therapeutic and Diagnostic Obstacles in the Fight Against Covid-19?, Journal of Drug Delivery Science and Technology (2022)
50. Short-Term Sars-Cov-2 Re-Infection Rate in Vaccinated Health Workers Based on Received Vaccines: A Cross-Sectional Study, Current Respiratory Medicine Reviews (2023)