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Fabrication of a Magnetic Nanocomposite Based on Natural Hydrogel: Pectin, Tragacanth Gum, Silk Fibroin, and Integrated Graphitic Carbon Nitride for Hyperthermia and Biological Features Publisher



Choopani L1 ; Aliabadi HAM2 ; Ganjali F1 ; Kashtiaray A1 ; Eivazzadehkeihan R1 ; Maleki A1 ; Salimibani M3 ; Karimi AH4 ; Salehpour N5 ; Mahdavi M6
Authors
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Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  3. 3. Department of Optics and Photonics, Wroclaw University of Science and Technology, Wroclaw, Poland
  4. 4. Mechanical Engineering Faculty, Isfahan University of Technology, Isfahan, Iran
  5. 5. Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Carbohydrate Polymer Technologies and Applications Published:2024


Abstract

The current study aimed to design and synthesize a new magnetic nanobiocomposite and assess its potential for biological applications and hyperthermia. For this purpose, in the first step, the Pectin (PC) and Tragacanth gum (TG) polymer was synthesized using CaCl2 as a cross-linking agent (PC-TG hydrogel). In the second step, natural Silk fibroin (SF) protein and graphitic carbon nitride (CN) were added to the hydrogel to upgrade the nanobiocomposite's strength and due to CN's pharmacology applications, respectively. Finally, for an enhanced hyperthermia application, PC-TG hydrogel/SF/CN was in situ magnetized with Fe3O4 magnetic nanoparticles (MNPs), and PC-TG hydrogel/SF/CN/Fe3O4 nanobiocomposite was synthesized. By using a vibrating-sample magnetometer (VSM), Fourier-transformed infrared (FTIR), thermogravimetric analysis (TGA), energy dispersive X-ray (EDX), X-ray diffraction (XRD), and field-emission scanning electron microscope (FESEM), the structural features and properties of the PC-TG hydrogel/SF/CN/Fe3O4 nanobiocomposite were determined. This magnetic nanobiocomposite's saturation magnetization value was 14.84 emu g-1. The hemolytic assay of this new nanobiocomposite demonstrated that the hemolysis percentage was 1.07 %, around 99.0 % of cells were able to survive, and the MTT assay was used to assess the anticancer activity against breast cancer cell lines (BT549). Additionally, 62.51 (W g-1) in 200.0 kHz was found to be the greatest specific absorption rate (SAR). These findings suggest that the recently created magnetic nanobiocomposite might function admirably in hyperthermia treatment when exposed to an alternating magnetic field. © 2024 The Author(s)
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