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Non-Coding Rnas and Hippo Signaling in Non-Small Cell Lung Cancer: Emerging Roles As Biomarkers and Therapeutic Targets Publisher



M Joulani MOHAMMADAMIN ; N Aghajamal NAHAL ; M Nouri MASOUMEH ; Fr Khajeh Faraz RAHMANI ; N Sharifi NAFISEH ; D Saghafi DENA ; M Amiri MAHAN ; A Abdollahzadeh ALI ; E Heidari EHSAN ; A Mirdamadian AMIN
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Source: Discover Oncology Published:2025


Abstract

The most common type of cancer and one with a high death rate is lung cancer, especially non-small cell lung cancer (NSCLC), which is mostly brought on by medication resistance, metastasis, and delayed diagnosis. The discovery of non-coding RNAs (ncRNAs), such as circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs), has revealed their vital involvement in the pathophysiology of lung cancer by controlling important cellular processes. The Hippo signaling pathway is one of the critical routes impacted by non-coding RNAs. It is involved in tumor suppression, apoptosis, and cell proliferation. The interaction between ncRNAs and the Hippo pathway in lung cancer is reviewed in this review, with an emphasis on the potential of these molecules as therapeutic targets as well as diagnostic and prognostic biomarkers. © 2025 Elsevier B.V., All rights reserved.
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