Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations

Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations Publisher Pubmed

Shirazi MMA¹ ; Saedi TA² ; Moghaddam ZS³ ; Nemati M⁴ ; Shiri R⁵ ; Negahdari B⁶ ; Goradel NH^{3, 7}

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1. Department of Molecular Virology, Pasteur Institute of Iran, Tehran, Iran
2. Department of Genetics, Faculty of Science, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran
3. Department of Medical Biotechnology, Maragheh University of Medical Sciences, Maragheh, Iran
4. Amir Oncology Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
5. Department of Basic Sciences, Maragheh University of Medical Sciences, Maragheh, Iran
6. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Arthropod-Borne Diseases Research Centre, Ardabil University of Medical Sciences, Ardabil, Iran

Source: Pharmacology and Therapeutics Published:2024

Abstract

Oncolytic adenoviruses (OAds), engineered Ads preferentially infect and lyse tumor cells, have attracted remarkable attention as immunotherapy weapons for the treatment of various malignancies. Despite hopeful successes in preclinical investigations and translation into clinical phases, they face some challenges that thwart their therapeutic effectiveness, including low infectivity of cancer cells, liver sequestration, pre-existing neutralizing antibodies, physical barriers to the spread of Ads, and immunosuppressive TME. Nanotechnology and nano-sized tools provide several advantages to overcome these limitations of OAds. Nano-sized tools could improve the therapeutic efficacy of OAds by enhancing infectivity and cellular uptake, targeting and protecting from pre-existing immune responses, masking and preventing liver tropism, and co-delivery with other therapeutic agents. Herein, we reviewed the constructs of various OAds and their application in clinical trials, as well as the limitations they have faced. Furthermore, we emphasized the potential applications of nanotechnology to solve the constraints of OAds to improve their anti-tumor activities. © 2024

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Style	Citing Format
MLA	Shirazi MMA, et al.. "Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations." Pharmacology and Therapeutics, vol. 256, no. , 2024, pp. -.
APA	Shirazi MMA, Saedi TA, Moghaddam ZS, Nemati M, Shiri R, Negahdari B, Goradel NH (2024). Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations. Pharmacology and Therapeutics, 256(), -.
Chicago	Shirazi MMA, Saedi TA, Moghaddam ZS, Nemati M, Shiri R, Negahdari B, Goradel NH. "Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations." Pharmacology and Therapeutics 256, no. (2024): -.
Harvard	Shirazi MMA et al. (2024) 'Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations', Pharmacology and Therapeutics, 256(), pp. -.
Vancouver	Shirazi MMA, Saedi TA, Moghaddam ZS, Nemati M, Shiri R, Negahdari B, et al.. Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations. Pharmacology and Therapeutics. 2024;256():-.
BibTex	@article{ author = {Shirazi MMA and Saedi TA and Moghaddam ZS and Nemati M and Shiri R and Negahdari B and Goradel NH}, title = {Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations}, journal = {Pharmacology and Therapeutics}, volume = {256}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Shirazi MMA AU - Saedi TA AU - Moghaddam ZS AU - Nemati M AU - Shiri R AU - Negahdari B AU - Goradel NH TI - Nanotechnology and Nano-Sized Tools: Newer Approaches to Circumvent Oncolytic Adenovirus Limitations JO - Pharmacology and Therapeutics VL - 256 IS - SP - EP - PY - 2024 ER -

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