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Metal-Free 2-Isocyanobiaryl-Based Cyclization Reactions: Phenanthridine Framework Synthesis Publisher Pubmed

Summary: Can metal-free reactions aid medicine? Research shows 2-isocyanobiaryls create valuable compounds for drugs without metal catalysts, offering greener solutions. #GreenChemistry #PharmaResearch

Doraghi F1 ; Amini A1 ; Ghanbarlou M1 ; Larijani B1 ; Mahdavi M1
Authors

Source: Molecular Diversity Published:2024


Abstract

The development of transition metal-free 2-isocyanobiaryl-based reactions has received much attention due to the widespread presence of phenanthidine frameworks as products in pharmacological chemistry and materials science. This review article focuses on the achievements from 2013 until now in various metal-free catalyzed reactions and discusses challenging mechanisms and features of the transformations. Graphical abstract: Isocyanides, in particular, 2-isocyanobiaryls have attracted extensive attention, due to their distinctive properties in the field of synthetic chemistry. The preparation of various phenanthridine-containing compounds from these scaffolds has been investigated in the two last decades. Hence, the synthesis of valuable bioactive phenanthridines via coupling reaction/cyclization of 2-isocyanobiaryls with many kinds of organic compounds is highlighted in this review. (Figure presented.). © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023.
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