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X-Linked Recessive Tlr7 Deficiency in ~1% of Men Under 60 Years Old With Life-Threatening Covid-19 Publisher Pubmed



Asano T1 ; Boisson B1, 2, 3 ; Onodi F4 ; Matuozzo D2, 3 ; Moncadavelez M1 ; Renkilaraj MRLM2, 3 ; Zhang P1 ; Meertens L4 ; Bolze A5, 89, 231 ; Materna M2, 3 ; Korniotis S6 ; Gervais A2, 3 ; Talouarn E2, 3 ; Bigio B1 Show All Authors
Authors
  1. Asano T1
  2. Boisson B1, 2, 3
  3. Onodi F4
  4. Matuozzo D2, 3
  5. Moncadavelez M1
  6. Renkilaraj MRLM2, 3
  7. Zhang P1
  8. Meertens L4
  9. Bolze A5, 89, 231
  10. Materna M2, 3
  11. Korniotis S6
  12. Gervais A2, 3
  13. Talouarn E2, 3
  14. Bigio B1
  15. Seeleuthner Y2, 3
  16. Bilguvar K7
  17. Zhang Y9
  18. Neehus AL2, 3
  19. Ogishi M1
  20. Pelham SJ1
  21. Le Voyer T2, 3
  22. Rosain J2, 3
  23. Philippot Q2, 3, 304
  24. Solerpalacin P10, 11, 12, 166, 469
  25. Colobran R12, 13, 14, 272
  26. Martinnalda A10, 11, 12
  27. Riviere JG10, 11, 12
  28. Tandjaouilambiotte Y15, 16, 472
  29. Chaibi K17, 18
  30. Shahrooei M19, 20
  31. Darazam IA21, 22, 196
  32. Olyaei NA19, 20
  33. Mansouri D23, 25
  34. Hatipoglu N26
  35. Palabiyik F26
  36. Novelli G28, 29, 147
  37. Novelli A30, 146
  38. Casari G31, 32, 194
  39. Aiuti A31, 33, 82, 194
  40. Carrera P32
  41. Bondesan S32
  42. Barzaghi F33, 194
  43. Roverequerini P31, 34
  44. Tresoldi C35
  45. Franco JL36, 87
  46. Rojas J36
  47. Reyes LF37
  48. Bustos IG37
  49. Arias AA1, 36, 38, 87
  50. Morelle G39, 413
  51. Kyheng C39
  52. Troya J40
  53. Planasserra L41, 42, 432, 433
  54. Schluter A41, 42, 432, 433
  55. Gut M43, 336
  56. Pujol A41, 42, 44
  57. Allende LM45, 46
  58. Rodriguezgallego C47, 48, 157
  59. Flores C49, 50, 51, 52, 109, 110, 111, 112, 310
  60. Cabreramarante O45
  61. Pleguezuelo DE45
  62. De Diego RP53, 109, 151
  63. Keles S54
  64. Aytekin G55, 221
  65. Akcan OM54
  66. Bryceson YT56, 95
  67. Bergman P57, 58
  68. Brodin P59, 94
  69. Smole D60
  70. Smith CIE58, 61
  71. Norlin AC58
  72. Campbell TM56
  73. Covill LE56
  74. Hammarstrom L62
  75. Panhammarstrom Q62
  76. Abolhassani H62, 63
  77. Mane S64
  78. Marr N65
  79. Ata M65
  80. Al Ali F65
  81. Khan T65
  82. Spaan AN1, 66
  83. Dalgard CL67, 68
  84. Bonfanti P69
  85. Biondi A70, 594
  86. Tubiana S71, 72, 520
  87. Burdet C71, 72, 73
  88. Nussbaum R74
  89. Kahnkirby A74
  90. Snow AL75
  91. Bustamante J1, 2, 3, 76, 224
  92. Puel A1, 2, 3
  93. Boissondupuis S1, 2, 3
  94. Zhang SY1, 2, 3
  95. Beziat V1, 2, 3
  96. Lifton RP7, 77
  97. Bastard P1, 2, 3
  98. Notarangelo LD9, 145
  99. Abel L1, 2, 3, 81
  100. Su HC9, 78, 145
  101. Jouanguy E1, 2, 3
  102. Amara A4
  103. Soumelis V6, 79
  104. Cobat A1, 2, 3
  105. Zhang Q1, 2, 3
  106. Casanova JL1, 2, 3, 184, 185
  107. Almuhsen S83
  108. Almulla F84
  109. Anderson MS85
  110. Andreakos E86
  111. Feldman HB88
  112. Biggs CM90
  113. Bogunovic D91
  114. Bondarenko A92, 242
  115. Bousfiha AA93, 245
  116. Bustamante CD96
  117. Butte MJ97
  118. Chakravorty S98
  119. Christodoulou J99
  120. Condinoneto A100
  121. Constantinescu SN101
  122. Cooper MA102
  123. Desai M103
  124. Drolet BA104
  125. El Baghdadi J105
  126. Espinosapadilla S106
  127. Fellay J107, 108
  128. Froidure A113, 114
  129. Gregersen PK115
  130. Haerynck F116, 338
  131. Hagin D117
  132. Halwani R118
  133. Heath JR119
  134. Henrickson SE120, 121
  135. Hsieh EWY122
  136. Husebye E123
  137. Imai K124
  138. Itan Y125, 126
  139. Jarvis ED127
  140. Karamitros T128
  141. Kisand K129
  142. Ku CL130
  143. Lau YL131
  144. Ling Y132
  145. Lucas CL133
  146. Maniatis T134
  147. Marodi L135
  148. Meyts I136, 137, 138
  149. Milner JD139
  150. Mironska K140
  151. Mogensen TH141
  152. Morio T142
  153. Ng LFP143, 144, 419, 420
  154. Ofarrelly C148
  155. Okada S149
  156. Planas AM152
  157. Prando C153
  158. Quintanamurci L154, 155
  159. Renia L143, 144
  160. Resnick I156
  161. Sanchoshimizu V158, 159
  162. Sediva A160, 362
  163. Seppanen MRJ161, 162, 462
  164. Shahrooei M19, 20
  165. Shcherbina A164, 463
  166. Slaby O165
  167. Tancevski I167
  168. Tangye SG168, 169
  169. Tayoun AA170
  170. Ramaswamy S170
  171. Turvey SE171
  172. Uddin F172, 173
  173. Uddin MJ174, 175
  174. Van De Beek D176, 581
  175. Vinh DC177, 178
  176. Von Bernuth H179, 180, 181
  177. Zatz M182, 254
  178. Zawadzki P183
  179. Foti G186
  180. Bellani G186
  181. Citerio G186
  182. Contro E186
  183. Pesci A187
  184. Valsecchi MG188
  185. Cazzaniga M189
  186. Abad J190
  187. Accordino G191
  188. Achille C192
  189. Aguileraalbesa S193
  190. Aguilocucurull A12, 14
  191. Ozkan EA195
  192. Albisures JAR197
  193. Aldave JC198
  194. Ramos MA199
  195. Khan TA200
  196. Aliberti A201
  197. Nadji SA202
  198. Alkan G203
  199. Alkhater SA204, 205
  200. Allardetservent J206
  201. Alonsoarias R207
  202. Alshahrani MS208
  203. Alsina L209, 210
  204. Alyanakian MA211
  205. Borrero BA212, 213
  206. Amoura Z214
  207. Antoli A215
  208. Arrestier R216
  209. Aubart M81, 218
  210. Auguet T219
  211. Avramenko I220
  212. Azot A222
  213. Bahram S223
  214. Bajolle F224
  215. Baldanti F225
  216. Baldolli A226
  217. Ballester M227
  218. Barrou B228
  219. Basso S229
  220. Bayhan GI230
  221. Bezrodnik L232
  222. Bilbao A233
  223. Blanchardrohner G234
  224. Blanco I235
  225. Blandinieres A236
  226. Blazquezgamero D237
  227. Bleibtreu A238
  228. Bloomfield M239, 240
  229. Bolivarprados M241
  230. Borghesi A192
  231. Borie R243
  232. Botdhlonevers E244
  233. Bousquet A246
  234. Boutolleau D247
  235. Bouvattier C248
  236. Boyarchuk O249
  237. Bravais J250
  238. Briones ML251
  239. Brunner ME252
  240. Bruno R253
  241. Bueno MRP254
  242. Bukhari H204
  243. Agra JJC255
  244. Capra R256
  245. Carapito R257
  246. Carrabba M258
  247. Casasnovas C259
  248. Caseris M260, 537
  249. Cassaniti I225
  250. Castelle M261
  251. Castelli F262
  252. De Vera MC263
  253. Castro MV254
  254. Catherinot E264
  255. Celik JB265
  256. Ceschi A266
  257. Chalumeau M224
  258. Charbit B267
  259. Cheng MP268
  260. Clave P241
  261. Clotet B235
  262. Codina A269
  263. Cohen Y15, 270, 271
  264. Comarmond C273
  265. Combes A274
  266. Comoli P229
  267. Corsico AG191
  268. Coskuner T275
  269. Cvetkovski A276
  270. Cyrus C277
  271. Dalmau D278
  272. Danion F279
  273. Darley DR280, 281
  274. Das V282
  275. Dauby N283
  276. Dauger S284
  277. De Munter P285
  278. De Pontual L286
  279. Dehban A19
  280. Delplancq G287
  281. Demoule A288
  282. Desguerre I218
  283. Di Sabatino A289
  284. Diehl JL290
  285. Dobbelaere S291
  286. Dominguezgarrido E292
  287. Dubost C293
  288. Ekwall O294, 295
  289. Bozdemir PE296
  290. Elnagdy MH297
  291. Emiroglu M203
  292. Endo A298
  293. Erdeniz EH299
  294. Aytekin SE54
  295. Lasa MPE300
  296. Euvrard R301
  297. Fabio G258
  298. Faivre L302
  299. Falck A303
  300. Fartoukh M304
  301. Faure M305
  302. Arquero MF306
  303. Ferrer R307, 308
  304. Ferreres J309
  305. Francois B311
  306. Fumado V312, 313, 314
  307. Fung KSC315
  308. Fusco F316
  309. Gagro A317, 318
  310. Solis BG53, 109
  311. Garcon P515
  312. Gaussem P319
  313. Gayretli Z320
  314. Gilherrera J321
  315. Gilardin L322
  316. Gatineau AG323, 324
  317. Gironaalarcon M325
  318. Godinez KAC326
  319. Goffard JC327
  320. Gonzales N328
  321. Gonzalezgranado LI329, 330
  322. Gonzalezmontelongo R109
  323. Guerder A331
  324. Gulhan B332
  325. Gumucio VD333
  326. Hanitsch LG334
  327. Gunst J335
  328. Hadjadj J337
  329. Hancerli S339
  330. Hariyan T340
  331. Heppekcan D341
  332. Hernandezbrito E342
  333. Ho PK343
  334. Holandapena MS344
  335. Horcajada JP345
  336. Hraiech S346
  337. Humbert L347
  338. Hung IFN348
  339. Iglesias AD139
  340. Inigocampos A109
  341. Jamme M349
  342. Arranz MJ278
  343. Jimeno MT350
  344. Jordan I325
  345. Yuksek SK351
  346. Kara YB352
  347. Karahan A353
  348. Karbuz A354
  349. Yasar KK355
  350. Kasapcopur O356
  351. Kashimada K357
  352. Demirkol YK358
  353. Kido Y359
  354. Kizil C360
  355. Kilic AO361
  356. Klocperk A362
  357. Koutsoukou A363
  358. Krol ZJ364
  359. Ksouri H365
  360. Kuentz P366
  361. Kwan AMC367
  362. Kwan YWM368
  363. Kwok JSY369
  364. Lagier JC370
  365. Lam DSY371
  366. Lampropoulou V372
  367. Lanternier F373
  368. Le Bourgeois F284
  369. Leo YS374
  370. Lopez RL375
  371. Leung D131
  372. Levin M376
  373. Levy M284
  374. Levy R224
  375. Li Z267
  376. Lilleri D225
  377. Lima EJAB377
  378. Linglart A378
  379. Lopezcollazo E379
  380. Lorenzosalazar JM109
  381. Louapre C380
  382. Lubetzki C380
  383. Lung KC381
  384. Luyt CE382
  385. Lye DC374, 383, 384, 385
  386. Magnone C386
  387. Marchioni E387
  388. Marioli C191
  389. Marjani M24
  390. Marques L388
  391. Pereira JM389
  392. Pueyo DM210
  393. Martinezpicado J390
  394. Marzana I233
  395. Matamartinez C391
  396. Mathian A214
  397. Matos LRB254
  398. Matthews GV392
  399. Mayaux J393
  400. Mclaughlingarcia R394
  401. Meersseman P395
  402. Mege JL396
  403. Mekontsodessap A216
  404. Melki I303
  405. Meloni F191
  406. Meritet JF397
  407. Merlani P398
  408. Mezidi M399
  409. Migeotte I400
  410. Millereux M401
  411. Million M402
  412. Mirault T403
  413. Mircher C404
  414. Mirsaeidi M405
  415. Mizoguchi Y406
  416. Modi BP407
  417. Mojoli F201
  418. Moncomble E408
  419. Melian AM409
  420. Martinez AM410
  421. Morandeira F411
  422. Morange PE412
  423. Mordacq C347
  424. Mouly SJ414
  425. Munozbarrera A109
  426. Nafati C415
  427. Nagashima S416
  428. Nakagama Y359
  429. Neven B417
  430. Neves JF418
  431. Ng YY421
  432. Nielly H293
  433. Medina YN394
  434. Cuadros EN422
  435. Ocejovinyals JG423
  436. Okamoto K298
  437. Oualha M224
  438. Ouedrani A211
  439. Ozcelik T27, 150, 424
  440. Ozkayaparlakay A332
  441. Pagani M201
  442. Papadaki M425
  443. Parizot C393
  444. Parola P323
  445. Pascreau T264
  446. Paul S426
  447. Pazartal E427
  448. Pedraza S428
  449. Pellecer NCG326
  450. Pellegrini S429
  451. Perezfernandez XL333
  452. Philippe A430
  453. Picod A15, 431
  454. De Chambrun MP274
  455. Piralla A225
  456. Ploin D434
  457. Poissy J435
  458. Poncelet G260, 537
  459. Poulakou G363
  460. Pouletty MS436
  461. Pourshahnazari P437
  462. Qiuchen JL12, 438
  463. Quentric P393
  464. Rambaud T15, 270
  465. Raoult D396
  466. Raoult V439
  467. Rebillat AS404
  468. Redin C108
  469. Resmini L440
  470. Ricart P441
  471. Richard JC442
  472. Rigobonnin R443
  473. Rivet N236
  474. Rocamorablanch G215
  475. Rodero MP444, 445
  476. Rodrigo C446
  477. Rodriguez LA377
  478. Rodriguezpalmero A41, 447
  479. Romero CS227
  480. Rothenbuhler A448
  481. Roux D449
  482. Rovina N363
  483. Rozenberg F450
  484. Ruch Y279
  485. Ruiz M451
  486. Del Prado MYR452
  487. Ruizrodriguez JC307, 308
  488. Sabaterriera J333
  489. Saks K453
  490. Salagianni M372
  491. Sanchez O454
  492. Sanchezmontalva A455
  493. Sanchezramon S456
  494. Schidlowski L153
  495. Schmidt J15
  496. Schmidt M457
  497. Schuetz C458
  498. Schweitzer CE459
  499. Scolari F460
  500. Seijo L461
  501. Seminario AG232
  502. Sene D212, 213
  503. Seng P402
  504. Senoglu S355
  505. Llovich AS278
  506. Siguret V464
  507. Siouti E372
  508. Smadja DM465
  509. Smith N267
  510. Sobh A466
  511. Solanich X215
  512. Soleviolan J467
  513. Soler C468
  514. Sozeri B275
  515. Stella GM191
  516. Stepanovskiy Y470
  517. Stoclin A471
  518. Taccone F400
  519. Taupin JL473
  520. Tavernier SJ474
  521. Tello LV300
  522. Terrier B475
  523. Thiery G476
  524. Thorball C108
  525. Thorn K295
  526. Thumerelle C347
  527. Tipu I477
  528. Tolstrup M478
  529. Tomasoni G479
  530. Toubiana J224
  531. Alvarez JT480
  532. Triantafyllia V86
  533. Trouilletassant S481, 482
  534. Tsang OTY484
  535. Tserel L485
  536. Tso EYK486
  537. Tucci A487
  538. Oz PKT203
  539. Ursini MV316
  540. Utsumi T406
  541. Uzunhan Y488
  542. Vabres P489
  543. Valenciaramos J490
  544. Van Den Rym AM53, 109
  545. Vandernoot I491
  546. Velezsantamaria V492
  547. Veliz SPZ326
  548. Vidigal MC493
  549. Viel S434
  550. Vilain C226
  551. Vilairemeunier ME404
  552. Villargarcia J494
  553. Vincent A248
  554. Vogt G495
  555. Voiriot G496
  556. Volokha A497
  557. Vuotto F347
  558. Wauters E498
  559. Wauters J499
  560. Wu AKL500
  561. Wu TC501
  562. Yahsi A502
  563. Yesilbas O503
  564. Yildiz M356
  565. Young BE374
  566. Yukselmis U504
  567. Zecca M229
  568. Zuccaro V253
  569. Van Praet J505
  570. Lambrecht BN506
  571. Van Braeckel E506
  572. Bosteels C506
  573. Hoste L507
  574. Hoste E508
  575. Bauters F506
  576. De Clercq J506
  577. Heijmans C509
  578. Slabbynck H510
  579. Naesens L511
  580. Florkin B512
  581. Boulanger C513
  582. Vanderlinden D514
  583. Annereau JP516
  584. Brisenoroa L516
  585. Gribouval O517
  586. Pelet A517
  587. Andrejak C518
  588. Angoulvant F519
  589. Bachelet D520
  590. Bartoli M521
  591. Basmaci R522
  592. Behilill S267
  593. Beluze M523
  594. Benkerrou D524
  595. Bhavsar K520
  596. Bouadma L520
  597. Bouchez S525
  598. Bouscambert M526
  599. Cervantesgonzalez M520
  600. Chair A520
  601. Chirouze C527, 565
  602. Coelho A528
  603. Couffignal C520
  604. Couffincadiergues S529, 575
  605. Dortenzio E521
  606. Debray MP520
  607. Deconinck L520
  608. Deplanque D530
  609. Descamps D520, 549
  610. Desvallee M531
  611. Diallo A521
  612. Diouf A528
  613. Dorival C524
  614. Dubos F347
  615. Duval X520, 550
  616. Elharrar B532
  617. Eloy P520
  618. Enouf V267, 551
  619. Esperou H529, 577
  620. Espositofarese M520
  621. Etienne M533
  622. Devouge EF533
  623. Gault N520
  624. Gaymard A526
  625. Ghosn J520
  626. Gigante T534
  627. Gilg M534
  628. Guedj J535
  629. Hoctin A528
  630. Hoffmann I520
  631. Houas I529
  632. Hulot JS536
  633. Jaafoura S529
  634. Kafif O72, 520
  635. Kaguelidou F260, 537
  636. Kali S520
  637. Khalil A520
  638. Khan C531
  639. Laouenan C520
  640. Laribi S520
  641. Le M520
  642. Le Hingrat Q520
  643. Le Mestre S521
  644. Le Nagard H538
  645. Lescure FX520
  646. Letrou S71, 72, 520
  647. Levy Y539
  648. Lina B481, 526
  649. Lingas G538
  650. Lucet JC520, 552
  651. Malvy D540, 561
  652. Mambert M528
  653. Mentre F520
  654. Meziane A524
  655. Mouquet H267
  656. Mullaert J520
  657. Neant N538
  658. Nguyen D540, 561
  659. Noret M541
  660. Nseir S347
  661. Papadopoulos A529
  662. Paul C521
  663. Peiffersmadja N520
  664. Perpoint T542
  665. Petrovsanchez V521
  666. Peytavin G520
  667. Pham H520
  668. Picone O522
  669. Piquard V72, 520
  670. Puechal O543
  671. Rabaud C544
  672. Rosacalatrava M526
  673. Rossignol B534
  674. Rossignol P544
  675. Roy C520
  676. Schneider M520
  677. Su R520
  678. Tardivon C520
  679. Tellier MC520
  680. Teoule F524
  681. Terrier O526
  682. Timsit JF520
  683. Tual C545
  684. Van Der Werf S267, 551
  685. Vanel N546
  686. Veislinger A545
  687. Visseaux B520, 552
  688. Wiedemann A539
  689. Yazdanpanah Y520, 552
  690. Alavoine L71, 72
  691. Behillil S547
  692. Charpentier C548
  693. Dechanet A72
  694. Ecobichon JL71, 72
  695. Frezouls W71, 72
  696. Houhou N72
  697. Lehacaut J71, 72
  698. Manchon P72
  699. Nouroudine M71, 72
  700. Quintin C71, 72
  701. Thy M553
  702. Vignali V71, 72
  703. Djossou F554
  704. Mergeayfabre M555
  705. Lucarelli A556
  706. Demar M554
  707. Bruneau L557
  708. Gerardin P558
  709. Maillot A557
  710. Payet C559
  711. Laviolle B560
  712. Laine F560
  713. Paris C560
  714. Desilledugast M560
  715. Fouchard J560
  716. Pistone T561
  717. Perreau P561
  718. Gissot V562
  719. Goas CLE562
  720. Montagne S563
  721. Richard L564
  722. Bouiller K565
  723. Desmarets M566
  724. Meunier A567
  725. Lefevre B568
  726. Jeulin H569
  727. Legrand K570
  728. Lomazzi S571
  729. Tardy B572
  730. Gagneuxbrunon A573
  731. Bertholon F574
  732. Botelhonevers E573
  733. Christelle K575
  734. Nicolas L575
  735. Roufai L575
  736. Amat K576
  737. Hendou S575
  738. Van Agtmael M579
  739. Algera AG578
  740. Appelman B579
  741. Van Baarle F578
  742. Bax D580
  743. Beudel M581
  744. Bogaard HJ582
  745. Bomers M579
  746. Bonta P582
  747. Bos L578
  748. Botta M578
  749. De Brabander J579
  750. De Bree G579
  751. De Bruin S578
  752. Buis DTP578
  753. Bugiani M582
  754. Bulle E578
  755. Chouchane O579
  756. Cloherty A580
  757. Dijkstra M589
  758. Dongelmans DA578
  759. Dujardin RWG578
  760. Elbers P578
  761. Fleuren L578
  762. Geerlings S579
  763. Geijtenbeek T580
  764. Girbes A578
  765. Goorhuis B579
  766. Grobusch MP579
  767. Hafkamp F580
  768. Hagens L578
  769. Hamann J584
  770. Harris V579
  771. Hemke R585
  772. Hermans SM579
  773. Heunks L578
  774. Hollmann M583
  775. Horn J578
  776. Hovius JW579
  777. De Jong MD586
  778. Koning R581
  779. Lim EHT578
  780. Van Mourik N578
  781. Nellen J579
  782. Nossent EJ582
  783. Paulus F578
  784. Peters E579
  785. Pinafuentes DAI581
  786. Van Der Poll T579
  787. Preckel B583
  788. Prins JM579
  789. Raasveld J578
  790. Reijnders T579
  791. De Rotte MCFJ589
  792. Schinkel M579
  793. Schultz MJ578
  794. Schrauwen FAP589
  795. Schuurmans A587
  796. Schuurmans J578
  797. Sigaloff K578
  798. Slim MA578, 579
  799. Smeele P582
  800. Smit M578
  801. Stijnis CS579
  802. Stilma W578
  803. Teunissen C588
  804. Thoral P578
  805. Tsonas AM578
  806. Tuinman PR579
  807. Van Der Valk M579
  808. Veelo D583
  809. Volleman C578
  810. De Vries H578
  811. Vught LA578, 579
  812. Van Vugt M579
  813. Wouters D589
  814. Zwinderman AH590
  815. Brouwer MC581
  816. Wiersinga WJ579
  817. Vlaar APJ578
  818. Tompkins MF68, 591
  819. Alba C68, 591
  820. Hupalo DN68, 591
  821. Rosenberger J68, 591
  822. Sukumar G68, 591
  823. Wilkerson MD68, 591
  824. Zhang X68, 591
  825. Lack J592
  826. Oler AJ593
  827. Dobbs K8
  828. Delmonte OM8
  829. Danielson JJ8
  830. Bettini LR594
  831. Dangio M594
  832. Beretta I595
  833. Imberti L596
  834. Sottini A596
  835. Quaresima V596
  836. Quirosroldan E262
  837. Rossi C597
Show Affiliations
Authors Affiliations
  1. 1. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, United States
  2. 2. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France
  3. 3. Imagine Institute, University of Paris, Paris, France
  4. 4. Laboratory of Genomes and Cell Biology of Disease, INSERM U944, CNRS UMR7212, University of Paris, Research Institute of Saint-Louis, Saint-Louis Hospital, Paris, France
  5. 5. Helix, San Mateo, CA, United States
  6. 6. University of Paris, INSERM U976, Paris, F-75006, France
  7. 7. Yale Center for Genome Analysis, Department of Genetics, Yale School of Medicine, New Haven, CT, United States
  8. 8. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, United States
  9. 9. NIAID Clinical Genomics Program, NIH, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, United States
  10. 10. Infection in Immunocompromised Pediatric Patients Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Catalonia, Barcelona, Spain
  11. 11. Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Autonomous University of Barcelona (UAB), Catalonia, Barcelona, Spain
  12. 12. Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Catalonia, Barcelona, Spain
  13. 13. Diagnostic Immunology Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Catalonia, Barcelona, Spain
  14. 14. Immunology Division, Genetics Department, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Universitat Autonoma de Barcelona (UAB), Catalonia, Barcelona, Spain
  15. 15. AP-HP, Avicenne Hospital, Intensive Care Unit, Bobigny, France
  16. 16. INSERM U1272, Hypoxia and Lung, Bobigny, France
  17. 17. Anesthesiology and Critical Care Medicine Department, AP-HP, Avicenne Hospital, Bobigny, France
  18. 18. Common and Rare Kidney Diseases, Sorbonne University, INSERM UMR-S 1155, Paris, France
  19. 19. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran
  20. 20. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium
  21. 21. Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  22. 22. Department of Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  23. 23. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  24. 24. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  25. 25. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  26. 26. Pediatric Infectious Diseases Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
  27. 27. Department of Molecular Biology and Genetics, University of Bilkent, Bilkent, Ankara, Turkey
  28. 28. Department of Biomedicine and Prevention, University of Rome “Tor Vergata, �, Rome, Italy
  29. 29. Neuromed Institute, IRCCS, IS, Pozzilli, Italy
  30. 30. Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesu Children Hospital, IRCCS, Rome, Italy
  31. 31. Vita-Salute San Raffaele University, Milan, Italy
  32. 32. Clinical Genomics, IRCCS San Raffaele Scientific Institute, Milan, Italy
  33. 33. San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Pediatric Immunohematology Unit, BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy
  34. 34. Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
  35. 35. Molecular Hematology Unit, IRCCS Ospedale San Raffaele, Milan, Italy
  36. 36. Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UdeA, Medellin, Colombia
  37. 37. Universidad de La Sabana, Chia, Colombia
  38. 38. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia
  39. 39. Department of General Pediatrics, Hopital Bicetre, AP-HP, University of Paris Saclay, Le Kremlin-Bicetre, France
  40. 40. Department of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain
  41. 41. Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08908, Spain
  42. 42. Center for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain
  43. 43. CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 4, Barcelona, 08028, Spain
  44. 44. Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain
  45. 45. Immunology Department, University Hospital 12 de Octubre, Research Institute Hospital 12 de Octubre (I+12), Madrid, Spain
  46. 46. Complutense University, Madrid, Spain
  47. 47. Department of Immunology, University Hospital of Gran Canaria Dr. Negrin, Canarian Health System, Las Palmas de Gran Canaria, Spain
  48. 48. Department of Clinical Sciences, University of Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain
  49. 49. Genomics Division, Institute of Technology and Renewable Energies (ITER), Santa Cruz de Tenerife, Spain
  50. 50. CIBER de Enfermedades Respiratorias, Health Institute of Carlos III, Madrid, Spain
  51. 51. Research Unit, University Hospital of N.S. de Candelaria, Santa Cruz de Tenerife, Spain
  52. 52. Institute of Biomedical Technologies (ITB), University of La Laguna, San Cristobal de La Laguna, Spain
  53. 53. Laboratory of Immunogenetics of Human Diseases, IdiPAZ Institute for Health Research, University Hospital “La Paz�, Madrid, Spain
  54. 54. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey
  55. 55. Konya City Hospital, Division of Allergy and Immunology, Konya, Turkey
  56. 56. Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden
  57. 57. Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institute, Stockholm, Sweden
  58. 58. Immunodeficiency Unit, Infectious Disease Clinic, Karolinska University Hospital, Stockholm, Sweden
  59. 59. Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institute, Solna, Sweden
  60. 60. Central Hospital-Anesthesia, Intensive Care Unit, Karlstad, Sweden
  61. 61. Department of Laboratory Medicine, Division of Biomolecular and Cellular Medicine, Karolinska Institute, Stockholm, Sweden
  62. 62. Department of Biosciences and Nutrition, SE14183, Huddinge, Karolinska Institute, Stockholm, Sweden
  63. 63. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  64. 64. Department of Genetics, Yale University, School of Medicine, New Haven, CT, United States
  65. 65. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar
  66. 66. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands
  67. 67. Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
  68. 68. American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
  69. 69. Department of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy
  70. 70. Pediatric Department, Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN, University of Milano, Bicocca-Fondazione MBBM, Ospedale San Gerardo, Monza, Italy
  71. 71. Centre d'Investigation Clinique, INSERM CIC 1425, Paris, France
  72. 72. Hopital Bichat Claude Bernard, AP-HP, Paris, France
  73. 73. Universite de Paris, IAME, INSERM UMR 1137, Paris, France
  74. 74. Invitae, San Francisco, CA, United States
  75. 75. Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
  76. 76. Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France
  77. 77. Laboratory of Genetics and Genomics, Rockefeller University, New York, NY, United States
  78. 78. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
  79. 79. AP-HP, Hopital Saint-Louis, Department of Immunology-Histocompatibility, Paris, 75010, France
  80. 80. Howard Hughes Medical Institute, New York, NY, United States
  81. 81. INSERM U1163, University of Paris, Imagine Institute, Paris, France
  82. 82. San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Vita Salute San Raffaele University, Milan, Italy
  83. 83. Immunology Research Laboratory, Department of Pediatrics, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia
  84. 84. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Dasman, Kuwait
  85. 85. Diabetes Center, University of California, San Francisco, San Francisco, CA, United States
  86. 86. Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation, The Academy of Athens, Athens, Greece
  87. 87. Group of Primary Immunodeficiencies, Universidad de Antioquia UdeA, Medellin, Colombia
  88. 88. Genetics Institute, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  89. 89. Pediatric Nephrology, Rheumatology, Dermatology, HFME, Hospices Civils de Lyon, National Referee Centre RAISE, INSERM U1111, Universite de Lyon, Lyon, France
  90. 90. Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada
  91. 91. Icahn School of Medicine at Mount Sinai, New York, NY, United States
  92. 92. Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine
  93. 93. Clinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
  94. 94. SciLifeLab, Department Of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
  95. 95. Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden
  96. 96. Stanford University, Stanford, CA, United States
  97. 97. Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, The Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States
  98. 98. Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, GA, United States
  99. 99. Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia
  100. 100. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
  101. 101. De Duve Institute, Ludwig Cancer Research, Brussels, Belgium
  102. 102. Washington University, School of Medicine, St. Louis, MO, United States
  103. 103. Bai Jerbai Wadia Hospital for Children, Mumbai, India
  104. 104. School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States
  105. 105. Genetics Unit, Military Hospital Mohamed V, Rabat, Morocco
  106. 106. Instituto Nacional de Pediatria (National Institute of Pediatrics), Mexico City, Mexico
  107. 107. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
  108. 108. Precision Medicine Unit, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
  109. 109. Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), Santa Cruz de Tenerife, Spain
  110. 110. Research Unit, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain
  111. 111. Instituto de Tecnologias Biomedicas (ITB), Universidad de La Laguna, San Cristobal de La Laguna, Spain
  112. 112. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
  113. 113. Pulmonology Department, Cliniques Universitaires Saint-Luc, Universite Catholique de Louvain, Brussels, Belgium
  114. 114. Institut de Recherche Experimentale et Clinique (IREC), Universite Catholique de Louvain, Brussels, Belgium
  115. 115. Feinstein Institute for Medical Research, Northwell Health USA, Manhasset, NY, United States
  116. 116. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
  117. 117. Genetics Institute Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  118. 118. Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
  119. 119. Institute for Systems Biology, Seattle, WA, United States
  120. 120. Department of Pediatrics, Division of Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, United States
  121. 121. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
  122. 122. Department of Pediatrics, Immunology and Microbiology, University of Colorado, School of Medicine, Aurora, CO, United States
  123. 123. Department of Medicine, Haukeland University Hospital, Bergen, Norway
  124. 124. Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
  125. 125. Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  126. 126. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  127. 127. Laboratory of Neurogenetics of Language, Howard Hughes Medical Institute, Rockefeller University, New York, NY, United States
  128. 128. Bioinformatics and Applied Genomics Unit, Hellenic Pasteur Institute, Athens, Greece
  129. 129. Molecular Pathology, Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  130. 130. Chang Gung University, Taoyuan, Taiwan
  131. 131. Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong
  132. 132. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
  133. 133. Department of Immunobiology, Yale University, School of Medicine, New Haven, CT, United States
  134. 134. Columbia University, Zuckerman Institute, New York, NY, United States
  135. 135. Primary Immunodeficiency Clinical Unit and Laboratory, Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
  136. 136. Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium
  137. 137. KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium
  138. 138. Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium
  139. 139. Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, United States
  140. 140. University Clinic for Children's Diseases, Department of Pediatric Immunology, Medical Faculty, University “St.Cyril and Methodij, �, Skopje, North Macedonia
  141. 141. Department of Biomedicine, Aarhus University, Aarhus, Denmark
  142. 142. Tokyo Medical and Dental University Hospital, Tokyo, Japan
  143. 143. A*STAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore
  144. 144. Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore, Singapore
  145. 145. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
  146. 146. Laboratory of Medical Genetics, IRCCS Bambino Gesu Children's Hospital, Rome, Italy
  147. 147. Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy
  148. 148. Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
  149. 149. Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  150. 150. Department of Molecular Biology and Genetics, Bilkent University, Bilkent, Ankara, Turkey
  151. 151. Laboratory of Immunogenetics of Human Diseases, Innate Immunity Group, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain
  152. 152. IIBB-CSIC, IDIBAPS, Barcelona, Spain
  153. 153. Faculdades Pequeno Principe, Instituto de Pesquisa Pele Pequeno Principe, Curitiba, Brazil
  154. 154. Human Evolutionary Genetics Unit, CNRS U2000, Institut Pasteur, Paris, France
  155. 155. Human Genomics and Evolution, College de France, Paris, France
  156. 156. University Hospital St. Marina, Varna, Bulgaria
  157. 157. Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain
  158. 158. Department of Paediatric Infectious Diseases and Virology, Imperial College London, London, United Kingdom
  159. 159. Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, United Kingdom
  160. 160. Department of Immunology, Second Faculty of Medicine Charles University, V Uvalu, University Hospital in Motol, Prague, Czech Republic
  161. 161. Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
  162. 162. Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
  163. 163. Saeed Pathobiology and Genetics Lab, Tehran, Iran
  164. 164. Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
  165. 165. Central European Institute of Technology, Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
  166. 166. Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain
  167. 167. Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria
  168. 168. Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
  169. 169. St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia
  170. 170. Al Jalila Children's Hospital, Dubai, United Arab Emirates
  171. 171. BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada
  172. 172. Centre for Precision Therapeutics, Genetic and Genomic Medicine Centre, NeuroGen Children Healthcare, Dhaka, Bangladesh
  173. 173. Holy Family Red Crescent Medical College, Dhaka, Bangladesh
  174. 174. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates
  175. 175. Cellular Intelligence (Ci) Lab, GenomeArc Inc., Toronto, ON, Canada
  176. 176. Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
  177. 177. Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montreal, QC, Canada
  178. 178. Infectious Disease Susceptibility Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada
  179. 179. Department of Pediatric Pneumology, Immunology and Intensive Care, Charite Universitatsmedizin, Berlin University Hospital Center, Berlin, Germany
  180. 180. Labor Berlin GmbH, Department of Immunology, Berlin, Germany
  181. 181. Berlin Institutes of Health (BIH), Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany
  182. 182. Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil
  183. 183. Molecular Biophysics Division, Faculty of Physics, A. Mickiewicz University, Poznan, Poland
  184. 184. Rockefeller University, Howard Hughes Medical Institute, New York, NY, United States
  185. 185. Necker Hospital for Sick Children, INSERM, Paris, France
  186. 186. Department of Emergency, Anesthesia and Intensive Care, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
  187. 187. Department of Pneumology, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
  188. 188. Center of Bioinformatics and Biostatistics, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
  189. 189. Phase I Research Center, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
  190. 190. Germans Trias i Pujol University Hospital, Research Institute, Badalona, Barcelona, Spain
  191. 191. Respiratory Diseases Division, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
  192. 192. Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  193. 193. Navarra Health Service Hospital, Pamplona, Spain
  194. 194. Immunohematology Unit, San Raffaele Hospital, Milan, Italy
  195. 195. Ondokuz Mayis University Medical Faculty Pediatrics, Samsun, Turkey
  196. 196. Department of Infectious Diseases, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  197. 197. Hospital Regional de Huehuetenango, “Dr. Jorge Vides de Molina, �, Huehuetenango, Guatemala
  198. 198. Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
  199. 199. Parc Sanitari Sant Joan de Deu, Sant Boi de Llobregat, Spain
  200. 200. Khyber Medical University, Khyber Pakhtunkhwa, Pakistan
  201. 201. Anesthesia and Intensive Care, Rianimazione I, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  202. 202. Virology Research Center, National Institutes of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  203. 203. Department of Pediatrics, Division of Pediatric Infectious Diseases, Selcuk University Faculty of Medicine, Konya, Turkey
  204. 204. Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  205. 205. Department of Pediatrics, King Fahad Hospital of the University, Al Khobar, Saudi Arabia
  206. 206. Intensive Care Unit, Hopital Europeen, Marseille, France
  207. 207. Immunology Department, Asturias Central University Hospital, Biosanitary Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain
  208. 208. Emergency and Critical Care Medicine Department, College of Medicine, Imam AbdulRahman Ben Faisal University, Dammam, Saudi Arabia
  209. 209. Clinical Immunology and Primary Immunodeficiencias Unit, Hospital Sant Joan de Deu, Institut de Recerca Sant Joan de Deu, Barcelona, Spain
  210. 210. Hospital Universitari Mutua de Terrassa, Universitat de Barcelona, Barcelona, Spain
  211. 211. Department of Biological Immunology, Necker Hospital for Sick Children, AP-HP and INEM, Paris, France
  212. 212. Internal Medicine Department, Hopital Lariboisiere, AP-HP, Paris, France
  213. 213. Universite de Paris, Paris, France
  214. 214. Internal Medicine Department, Pitie-Salpetriere Hospital, Paris, France
  215. 215. Department of Internal Medicine, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
  216. 216. Service de Medecine Intensive Reanimation, Hopitaux Universitaires Henri Mondor, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe de Recherche Clinique CARMAS, Faculte de Sante de Creteil, Universite Paris Est Creteil, Creteil, France
  217. 217. Groupe de Recherche Clinique CARMAS, Faculte de Sante de Creteil, Universite Paris Est Creteil, Creteil, France
  218. 218. Pediatric Neurology Department, Necker-Enfants Malades Hospital, AP-HP, Paris, France
  219. 219. Hospital U. de Tarragona Joan XXIII. Universitat Rovira i Virgili (URV), IISPV, Tarragona, Spain
  220. 220. Department of Propedeutics of Pediatrics and Medical Genetics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
  221. 221. Department of Immunology and Allergy, Konya City Hospital, Konya, Turkey
  222. 222. Private Practice, Paris, France
  223. 223. INSERM U1109, University of Strasbourg, Strasbourg, France
  224. 224. Necker Hospital for Sick Children, Paris University, AP-HP, Paris, France
  225. 225. Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  226. 226. Department of Infectious Diseases, CHU de Caen, Caen, France
  227. 227. Consorcio Hospital General Universitario, Valencia, Spain
  228. 228. Department of Urology, Nephrology, Transplantation, APHP-SU, Sorbonne Universite, INSERM U 1082, Paris, France
  229. 229. Cell Factory and Pediatric Hematology-Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  230. 230. Yildirim Beyazit University, Faculty of Medicine, Ankara City Hospital, Children's Hospital, Ankara, Turkey
  231. 231. University of Lyon, CIRI, INSERM U1111, National Referee Centre RAISE, Pediatric Rheumatology, HFME, Hospices Civils de Lyon, Lyon, France
  232. 232. Center for Clinical Immunology, CABA, Buenos Aires, Argentina
  233. 233. Department of Laboratory, Cruces University Hospital, Barakaldo, Bizkaia, Spain
  234. 234. Paediatric Immunology and Vaccinology Unit, Geneva University Hospitals, Faculty of Medicine, Geneva, Switzerland
  235. 235. University Hospital and Research Institute “Germans Trias i Pujol, �, IrsiCaixa AIDS Research Institute, UVic-UCC, Badalona, Spain
  236. 236. Hematology, Georges Pompidou Hospital, AP-HP, Paris, France
  237. 237. Pediatric Infectious Diseases Unit, Instituto de Investigacion Hospital 12 de Octubre (imas12), Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain
  238. 238. Infectious Disease Unit, Pitie-Salpetriere Hospital, AP-AP, Paris, France
  239. 239. Department of Pediatrics, Thomayer's Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic
  240. 240. Department of Immunology, Motol University Hospital, Second Faculty of Medicine, Charles University, Prague, Czech Republic
  241. 241. Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (Ciberehd), Hospital de Mataro, Consorci Sanitari del Maresme, Mataro, Spain
  242. 242. Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
  243. 243. Service de Pneumologie, Hopital Bichat, AP-HP, Paris, France
  244. 244. Department of Infectious Diseases, CIC1408, GIMAP CIRI INSERM U1111, University Hospital of Saint-Etienne, Saint-Etienne, France
  245. 245. Clinical Immunology Unit, Pediatric Infectious Disease Department, Faculty of Medicine and Pharmacy, Averroes University Hospital, LICIA Laboratoire d'Immunologie Clinique, d'Inflammation et d'Allergie, Hassann Ii University., Casablanca, Morocco
  246. 246. Begin Military Hospital, St Mande, France
  247. 247. Sorbonne Universite, INSERM, Institut Pierre Louis d'Epidemiologie et de Sante Publique (iPLESP), AP-HP, Hopital Pitie Salpetriere, Service de Virologie, Paris, France
  248. 248. Endocrinology Unit, AP-HP Hopitaux Universitaires Paris-Sud, Le Kremlin-Bicetre, France
  249. 249. Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  250. 250. Pneumology Unit, Tenon Hospital, AP-HP, Paris, France
  251. 251. Department of Respiratory Diseases, Hospital Clinico y Universitario de Valencia, Valencia, Spain
  252. 252. Intensive Care Unit, Reseau Hospitalier Neuchatelois, Neuchatel, Switzerland
  253. 253. Infectious Diseases Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  254. 254. Human Genome and Stem Cell Research Center, University of Sao Paulo, Sao Paulo, Brazil
  255. 255. Hospital Insular, Las Palmas de Gran Canaria, Spain
  256. 256. MS Center, Spedali Civili, Brescia, Italy
  257. 257. Laboratoire d'ImmunoRhumatologie Moleculaire, Plateforme GENOMAX, INSERM UMR_S 1109, Faculte de Medecine, ITI TRANSPLANTEX NG, Universite de Strasbourg, Strasbourg, France
  258. 258. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
  259. 259. Neuromuscular Unit, Neurology Department, Hospital Universitari de Bellvitge-IDIBELL and CIBERER, Barcelona, Spain
  260. 260. Hopital Robert Debre, Paris, France
  261. 261. Pediatric Immunohematology Unit, Necker Enfants Malades Hospital, AP-HP, Paris, France
  262. 262. Department of Infectious and Tropical Diseases, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy
  263. 263. Doctoral Health Care Center, Canarian Health System, Las Palmas de Gran Canaria, Spain
  264. 264. Hopital Foch, Suresnes, France
  265. 265. Selcuk University Faculty of Medicine, Department of Anesthesiology and Reanimation, Intensive Care Medicine Unit, Konya, Turkey
  266. 266. Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, Faculty of Biomedical Sciences, Universita della Svizzera Italiana, Lugano, Switzerland
  267. 267. Pasteur Institute, Paris, France
  268. 268. McGill University Health Centre, Montreal, Canada
  269. 269. Clinical Biochemistry, Pathology, Paediatric Neurology and Molecular Medicine Department and Biobank, Institut de Recerca Sant Joan de Deu and CIBERER-ISCIII, Esplugues, Spain
  270. 270. University Sorbonne Paris Nord, Bobigny, France
  271. 271. INSERM, U942, Paris, F-75010, France
  272. 272. Hospital Universitari Vall d'Hebron, Barcelona, Spain
  273. 273. Pitie-Salpetriere Hospital, Paris, France
  274. 274. Service de medecine Intensive Reanimation, Groupe Hospitalier Pitie-Salpetriere, Sorbonne Universite, Paris, France
  275. 275. Umraniye Training and Research Hospital, Istanbul, Turkey
  276. 276. Faculty of Medical Sciences, University “Goce Delcev, �, Shtip, North Macedonia
  277. 277. Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  278. 278. Fundacio Docencia i Recerca Mutua Terrassa, Barcelona, Spain
  279. 279. Maladies Infectieuses et Tropicales, Nouvel Hopital Civil, CHU Strasbourg, Strasbourg, France
  280. 280. UNSW Medicine, St Vincent's Clinical School, Sydney, NSW, Australia
  281. 281. Department of Thoracic Medicine, St Vincent's Hospital Darlinghurst, Sydney, NSW, Australia
  282. 282. Intensive Care Unit, Montreuil Hospital, Montreuil, France
  283. 283. CHU Saint-Pierre, Universite Libre de Bruxelles (ULB), Brussels, Belgium
  284. 284. Pediatric Intensive Care Unit, Robert-Debre University Hospital, AP-HP, Paris, France
  285. 285. General Internal Medicine, University Hospitals Leuven, Leuven, Belgium
  286. 286. Hopital Jean Verdier, AP-HP, Bondy, France
  287. 287. Centre de Genetique Humaine, CHU Besancon, Besancon, France
  288. 288. Sorbonne Universite Medecine, AP-HP, Sorbonne Universite site Pitie-Salpetriere, Paris, France
  289. 289. Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
  290. 290. Intensive Care Unit, Georges Pompidou Hospital, AP-HP, Paris, France
  291. 291. Department of Pneumology, AZ Delta, Roeselare, Belgium
  292. 292. Molecular Diagnostic Unit, Fundacion Rioja Salud, La Rioja, Logrono, Spain
  293. 293. Begin Military Hospital, Saint Mande, France
  294. 294. Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  295. 295. Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  296. 296. Bursa City Hospital, Bursa, Turkey
  297. 297. Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  298. 298. Tokyo Medical and Dental University, Tokyo, Japan
  299. 299. Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey
  300. 300. Intensive Care Medicine, Donostia University Hospital, Biodonostia Institute of Donostia, CIBER Enfermedades Respiratorias ISCIII, Donostia, Spain
  301. 301. Internal Medicine, University Hospital Edouard Herriot, Hospices Civils de Lyon, Lyon, France
  302. 302. Centre de Genetique, CHU Dijon, Dijon, France
  303. 303. Robert Debre Hospital, Paris, France
  304. 304. AP-HP Tenon Hospital, Paris, France
  305. 305. Sorbonne Universites, UPMC University of Paris, Paris, France
  306. 306. Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
  307. 307. Intensive Care Department, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Catalonia, Barcelona, Spain
  308. 308. Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Catalonia, Barcelona, Spain
  309. 309. Intensive Care Unit, Hospital Clinico y Universitario de Valencia, Valencia, Spain
  310. 310. Instituto de Tecnologias Biomedicas (ITB), Universidad de La Laguna, Santa Cruz de Tenerife, Spain
  311. 311. CHU Limoges, INSERM CIC 1435, UMR 1092, Limoges, France
  312. 312. Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Deu, Barcelona, Spain
  313. 313. Institut de Recerca Sant Joan de Deu, Spain
  314. 314. Universitat de Barcelona (UB), Barcelona, Spain
  315. 315. Department of Pathology, United Christian Hospital, Hong Kong
  316. 316. Institute of Genetics and Biophysics “Adriano Buzzati-Traverso, �, IGB-CNR, Naples, Italy
  317. 317. Department of Pediatrics, Children's Hospital Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia
  318. 318. Josip Juraj Strossmayer University of Osijek, Medical Faculty Osijek, Osijek, Croatia
  319. 319. Hematology, AP-HP, Hopital Europeen Georges Pompidou, INSERM UMR-S1140, Paris, France
  320. 320. Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Karadeniz Technical University, Trabzon, Turkey
  321. 321. Division of Immunology, Hospital General Universitario, Instituto de Investigacion Sanitaria “Gregorio Maranon, �, Madrid, Spain
  322. 322. Begin Military Hospital, Begin, France
  323. 323. Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU Mediterranee Infection, Marseille, France
  324. 324. Armed Forces Center for Epidemiology and Public Health (CESPA), Marseille, France
  325. 325. Pediatric Intensive Care Unit, Hospital Sant Joan de Deu, Barcelona, Spain
  326. 326. Gestion Integral en Salud, Guatemala
  327. 327. Department of Internal Medicine, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
  328. 328. Immunodeficiencies Unit, Research Institute Hospital, Madrid, Spain
  329. 329. Primary Immunodeficiencies Unit, Pediatrics, University Hospital 12 de Octubre, Madrid, Spain
  330. 330. School of Medicine Complutense, University of Madrid, Madrid, Spain
  331. 331. Assistance Publique Hopitaux de Paris, Paris, France
  332. 332. Ankara City Hospital, Ankara, Turkey
  333. 333. Department of Intensive Care, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
  334. 334. Immunodeficiency Outpatient Clinic, Institute for Medical Immunology, FOCIS Center of Excellence, Charite Universitatsmedizin Berlin, Germany
  335. 335. Surgical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
  336. 336. CNAG-CRG, Barcelona Institute of Science and Technology, Barcelona, Spain
  337. 337. Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hopital Cochin, Paris, France
  338. 338. Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, PID Research Lab, Ghent University Hospital, Ghent, Belgium
  339. 339. Department of Pediatrics (Infectious Diseases), Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
  340. 340. I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  341. 341. Health Sciences University, Darica Farabi Education and Research Hospital, Kocaeli, Turkey
  342. 342. Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrin, Canarian Health System, Las Palmas de Gran Canaria, Spain
  343. 343. Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong
  344. 344. Intensive Care Unit, Marques de Valdecilla Hospital, Santander, Spain
  345. 345. Hospital del Mar, Institut Hospital del Mar d'Investigacions Mediques (IMIM), UAB, UPF, Barcelona, Spain
  346. 346. Intensive Care Unit, APHM, Marseille, France
  347. 347. CHU Lille, Lille, France
  348. 348. Department of Medicine, University of Hong Kong, Hong Kong
  349. 349. Centre Hospitalier Intercommunal Poissy Saint Germain en Laye, Poissy, France
  350. 350. IHU Mediterranee Infection, Service de l'Information Medicale, Hopital de la Timone, Marseille, France
  351. 351. Health Science University Ankara City Hospital, Ankara, Turkey
  352. 352. School of Medicine, General Surgery Department Fevzi Cakmak Mah, Marmara University, Istanbul, Turkey
  353. 353. Mersin City Education and Research Hospital, Mersin, Turkey
  354. 354. Division of Pediatric Infectious Diseases, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey
  355. 355. Department of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
  356. 356. Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey
  357. 357. Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan
  358. 358. Health Sciences University, Umraniye Education and Research Hospital, Istanbul, Turkey
  359. 359. Department of Parasitology, Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan
  360. 360. Pediatric Infectious Diseases Unit of Osman Gazi University Medical School, Eskisehir, Turkey
  361. 361. Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
  362. 362. Department of Immunology, Second Faculty of Medicine, Charles University, University Hospital in Motol, Prague, Czech Republic
  363. 363. ICU, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Medical School, “Sotiria� General Hospital of Chest Diseases, Athens, Greece
  364. 364. Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
  365. 365. Clinique des Soins Intensifs, HFR Fribourg, Fribourg, Switzerland
  366. 366. Oncobiologie Genetique Bioinformatique, PC Bio, CHU Besancon, Besancon, France
  367. 367. Department of Intensive Care, Tuen Mun Hospital, Hong Kong
  368. 368. Paediatric Infectious Disease Unit, Hospital Authority Infectious Disease Center, Princess Margaret Hospital, Hong Kong
  369. 369. Department of Pathology, Queen Mary Hospital, Hong Kong
  370. 370. Aix Marseille Univ, IRD, MEPHI, IHU Mediterranee Infection, Marseille, France
  371. 371. Department of Paediatrics, Tuen Mun Hospital, Hong Kong
  372. 372. Biomedical Research Foundation of the Academy of Athens, Athens, Greece
  373. 373. Necker Hospital, Paris, France
  374. 374. National Centre for Infectious Diseases, Singapore, Singapore
  375. 375. Hospital Universitario Reina Sofia, Cordoba, Spain
  376. 376. Imperial College, London, United Kingdom
  377. 377. Hospital General San Juan de Dios, Ciudad de Guatemala, Guatemala
  378. 378. Endocrinology and Diabetes for Children, AP-HP, Bicetre Paris-Saclay Hospital, Le Kremlin-Bicetre, France
  379. 379. Innate Immunity Group, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain
  380. 380. Neurology Unit, AP-HP Pitie-Salpetriere Hospital, Paris University, Paris, France
  381. 381. Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong
  382. 382. Intensive Care Unit, AP-HP Pitie-Salpetriere Hospital, Paris University, Paris, France
  383. 383. Tan Tock Seng Hospital, Singapore, Singapore
  384. 384. Yong Loo Lin School of Medicine, Singapore, Singapore
  385. 385. Lee Kong Chian School of Medicine, Singapore, Singapore
  386. 386. Hospital de Ninos Dr. Ricardo Gutierrez, Buenos Aires, Argentina
  387. 387. Neurooncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy
  388. 388. Coordenadora da Unidade de Infeciologia e Imunodeficiencias do Servico de Pediatria, Centro Materno-Infantil do Norte, Porto, Portugal
  389. 389. Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
  390. 390. IrsiCaixa AIDS Research Institute, ICREA, UVic-UCC, Research Institute “Germans Trias i Pujol, �, Badalona, Spain
  391. 391. Intensive Care Unit, Hospital General Universitario “Gregorio Maranon, �, Madrid, Spain
  392. 392. University of New South Wales, Sydney, NSW, Australia
  393. 393. AP-HP Pitie-Salpetriere Hospital, Paris, France
  394. 394. Department of Pediatrics, Complejo Hospitalario Universitario Insular-Materno Infantil, Canarian Health System, Las Palmas de Gran Canaria, Spain
  395. 395. Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
  396. 396. Aix-Marseille University, APHM, Marseille, France
  397. 397. AP-HP Cohin Hospital, Paris, France
  398. 398. Department of Critical Care Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
  399. 399. Hospices Civils de Lyon, Hopital de la Croix-Rousse, Lyon, France
  400. 400. Hopital Erasme, Brussels, Belgium
  401. 401. Centre Hospitalier de Gonesse, Gonesse, France
  402. 402. Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Mediterranee Infection, Marseille, France
  403. 403. Vascular Medicine, Georges Pompidou Hospital, AP-HP, Paris, France
  404. 404. Institut Jerome Lejeune, Paris, France
  405. 405. Division of Pulmonary and Critical Care, College of Medicine-Jacksonville, University of Florida, Jacksonville, FL, United States
  406. 406. Department of Pediatrics, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
  407. 407. BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada
  408. 408. Medecine Intensive Reanimation, Hopitaux Universitaires Henri Mondor, Assistance Publique-Hopitaux de Paris (AP-HP), Creteil, France
  409. 409. Guanarteme Health Care Center, Canarian Health System, Las Palmas de Gran Canaria, Spain
  410. 410. Regional University Hospital of Malaga, Malaga, Spain
  411. 411. Department of Immunology, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
  412. 412. Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille, France
  413. 413. Department of General Paediatrics, Hopital Bicetre, AP-HP, University of Paris Saclay, Le Kremlin-Bicetre, France
  414. 414. INSERM U1144, Universite de Paris, DMU INVICTUS, AP-HP.Nord, Departement de Medecine Interne, Lariboisiere Hospital, Paris, France
  415. 415. CHU de La Timone, Marseille, France
  416. 416. Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  417. 417. Pediatric Immunology and Rheumatology Department, Necker Hospital, AP-HP, Paris, France
  418. 418. Centro Hospitalar Universitario de Lisboa Central, Lisbon, Portugal
  419. 419. Infectious Disease Horizontal Technology Centre, A*STAR, Singapore, Singapore
  420. 420. Singapore Immunology Network, A*STAR, Singapore
  421. 421. Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong
  422. 422. Regional Universitary Hospital of Malaga, Malaga, Spain
  423. 423. Department of Immunology, Hospital Universitario Marques de Valdecilla, Santander, Spain
  424. 424. Bilkent University, Department of Molecular Biology and Genetics, Ankara, Turkey
  425. 425. BRFAA, Athens, Greece
  426. 426. Department of Immunology, CIC1408, GIMAP CIRI INSERM U1111, University Hospital of Saint-Etienne, Saint-Etienne, France
  427. 427. Department of Immunology, Hospital Universitario 12 de Octubre, Instituto de Investigacion Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain
  428. 428. Unit of Biochemistry, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
  429. 429. Diabetes Research Institute, IRCCS San Raffaele Hospital, Milan, Italy
  430. 430. AP-HP Hopitaux Universitaires Paris-Sud, Le Kremlin-Bicetre, France
  431. 431. INSERM UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT), University of Paris, Paris, France
  432. 432. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, Barcelona, Spain
  433. 433. CIBERER U759, ISCiii, Madrid, Spain
  434. 434. Hospices Civils de Lyon, Lyon, France
  435. 435. Univ. Lille, INSERM U1285, CHU Lille, Pole de Medecine Intensive-Reanimation, CNRS, UMR 8576-Unite de Glycobiologie Structurale et Fonctionnelle, Lille, France
  436. 436. Department of General Pediatrics, Robert Debre Hospital, Paris, France
  437. 437. University of British Columbia, Vancouver, BC, Canada
  438. 438. Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Catalonia, Barcelona, Spain
  439. 439. Centre Hospitalier de Saint-Denis, St Denis, France
  440. 440. Paris Cardiovascular Center, PARCC, INSERM, Universite de Paris, Paris, France
  441. 441. Germans Trias i Pujol Hospital, Badalona, Spain
  442. 442. Medical Intensive Care Unit, Hopital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
  443. 443. Department of Clinical Laboratory, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
  444. 444. Universite de Paris, CNRS UMR-8601, Paris, France
  445. 445. Team Chemistry and Biology, Modeling and Immunology for Therapy, CBMIT, Paris, France
  446. 446. Germans Trias i Pujol University Hospital, Research Institute, Badalona, Spain
  447. 447. University Hospital Germans Trias i Pujol, Badalona, Catalonia, Barcelona, Spain
  448. 448. AP-HP Hopitaux Universitaires Paris-Sud, Paris, France
  449. 449. Intensive Care Unit, Louis-Mourier Hospital, Colombes, France
  450. 450. Virology Unit, Universite de Paris, Cohin Hospital, AP-HP, Paris, France
  451. 451. Neurometabolic Diseases Laboratory, CIBERER U759, Barcelona, Spain
  452. 452. Hospital San Pedro, Logrono, Spain
  453. 453. University of Tartu, Institute of Biomedicine and Translational Medicine, Tartu, Estonia
  454. 454. Respiratory Medicine, Georges Pompidou Hospital, AP-HP, Paris, France
  455. 455. Infectious Diseases Department, International Health Program of the Catalan Institute of Health (PROSICS), Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autonoma de Barcelona, Barcelona, Spain
  456. 456. Hospital Clinico San Carlos and IdSSC, Madrid, Spain
  457. 457. Service de Medecine Intensive Reanimation, Institut de Cardiologie, Hopital Pitie-Salpetriere, Paris, France
  458. 458. Department of Pediatrics, Medizinische Fakultat Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
  459. 459. CHRU de Nancy, Hopital d'Enfants, Vandoeuvre, France
  460. 460. Nephrology, University of Brescia, Brescia, Italy
  461. 461. Clinica Universidad de Navarra and Ciberes, Madrid, Spain
  462. 462. HUS Helsinki University Hospital, Children and Adolescents, Rare Disease Center, Inflammation Center, Adult Immunodeficiency Unit, Majakka, Helsinki, Finland
  463. 463. D. Rogachev National Medical, Research Center of Pediatric Hematology, Oncology, Immunoogy, Moscow, Russian Federation
  464. 464. Haematology Laboratory, Lariboisiere Hospital, University of Paris, Paris, France
  465. 465. INSERM U1140, University of Paris, European Georges Pompidou Hospital, Paris, France
  466. 466. Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  467. 467. Intensive Care Medicine, Hospital Universitario de Gran Canaria Dr. Negrin, Canarian Health System, Las Palmas de Gran Canaria, Spain
  468. 468. CHU de Saint Etienne, Saint-Priest-en-Jarez, France
  469. 469. EU, Barcelona, Spain
  470. 470. Department of Pediatric Infectious Diseases and Pediatric Immunology, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
  471. 471. Gustave Roussy Cancer Campus, Villejuif, France
  472. 472. Intensive Care Unit, Avicenne Hospital, AP-HP, Bobigny, France
  473. 473. Laboratory of Immunology and Histocompatibility, Saint-Louis Hospital, Paris University, Paris, France
  474. 474. Center for Inflammation Research, Laboratory of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium
  475. 475. Department of Internal Medicine, Universite de Paris, INSERM, U970, PARCC, Paris, F-75015, France
  476. 476. Service de Medecine Intensive Reanimation, CHU de Saint-Etienne, France
  477. 477. University of Management and Technology, Lahore, Pakistan
  478. 478. Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
  479. 479. First Division of Anesthesiology and Critical Care Medicine, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy
  480. 480. Intensive Care Department, Hospital Universitari MutuaTerrassa, Universitat Barcelona, Terrassa, Spain
  481. 481. Virpath Laboratory, International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS U5308, ENS, UCBL, Lyon, France
  482. 482. Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Benite, France
  483. 483. Infanta Leonor University Hospital, Madrid, Spain
  484. 484. Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong
  485. 485. University of Tartu, Institute of Clinical Medicine, Tartu, Estonia
  486. 486. Department of Medicine, United Christian Hospital, Hong Kong
  487. 487. Hematology Department, ASST Spedali Civili di Brescia, Brescia, Italy
  488. 488. Pneumologie, Hopital Avicenne, AP-HP, INSERM U1272, Universite Sorbonne Paris Nord, Bobigny, France
  489. 489. Dermatology Unit, Laboratoire GAD, INSERM UMR1231 LNC, Universite de Bourgogne, Dijon, France
  490. 490. University Hospital of Burgos, Burgos, Spain
  491. 491. Center of Human Genetics, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
  492. 492. Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain
  493. 493. University of Sao Paulo, Sao Paulo, Brazil
  494. 494. Hospital del Mar-IMIM Biomedical Research Institute, Catalonia, Barcelona, Spain
  495. 495. Neglected Human Genetics Laboratory, INSERM, University of Paris, Paris, France
  496. 496. Sorbonne Universite, Service de Medecine Intensive Reanimation, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Paris, France
  497. 497. Pediatric Infectious Disease and Pediatric Immunology Department, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
  498. 498. Department of Pneumology, University Hospitals Leuven, Leuven, Belgium
  499. 499. Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology, and Transplantation, Leuven, Belgium
  500. 500. Department of Clinical Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong
  501. 501. Department of Medicine, Queen Elizabeth Hospital, Hong Kong
  502. 502. Ankara City Hospital, Children's Hospital, Ankara, Turkey
  503. 503. Division of Pediatric Infectious Disease, Department of Pediatrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
  504. 504. Health Sciences University, Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey
  505. 505. Department of Nephrology and Infectiology, AZ Sint-Jan, Bruges, Belgium
  506. 506. Department of Pulmonology, Ghent University Hospital, Belgium
  507. 507. Department of Pediatric Pulmonology and Immunology, Ghent University Hospital, Ghent, Belgium
  508. 508. Department of Intensive Care Unit, Ghent University Hospital, Ghent, Belgium
  509. 509. Department of Pediatric Hemato-oncology, Jolimont Hospital, La louviere, Belgium
  510. 510. Department of Pulmonology, ZNA Middelheim, Antwerp, Belgium
  511. 511. Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium
  512. 512. Department of Pediatric Immuno-Hemato-Rheumatology, CHR Citadelle, Liege, Belgium
  513. 513. Department of Pediatric Hemato-Oncology, UCL Louvain, Brussels, Belgium
  514. 514. Department of Pediatrics, Saint Luc, UCL Louvain, Brussels, Belgium
  515. 515. Intensive Care Unit, Grand Hopital de l'Est Francilien Site de Marne-La-Vallee, Jossigny, France
  516. 516. Medetia Pharmaceuticals, Paris, France
  517. 517. Imagine Institute, Universite de Paris, INSERM UMR 1163, Paris, France
  518. 518. CHU Amiens, Amiens, France
  519. 519. Hopital Necker, Paris, France
  520. 520. Hopital Bichat, Paris, France
  521. 521. ANRS, Paris, France
  522. 522. Hopital Louis Mourier, Colombes, France
  523. 523. F-CRIN Partners Platform, Paris, France
  524. 524. INSERM UMR 1136, Paris, France
  525. 525. CHU Nantes, France
  526. 526. INSERM UMR 1111, Lyon, France
  527. 527. CHRU Jean Minjoz, Besancon, France
  528. 528. INSERM UMR 1018, Paris, France
  529. 529. INSERM Sponsor, Paris, France
  530. 530. Centre d'Investigation Clinique, INSERM CIC 1403, Centre Hospitalo Universitaire de Lille, Lille, France
  531. 531. INSERM UMR 1219, Bordeaux, France
  532. 532. CHI de Creteil, Creteil, France
  533. 533. CHU Rouen, Rouen, France
  534. 534. F-CRIN INI-CRCT, Nancy, France
  535. 535. Universite de Paris, INSERM, IAME, Paris, F-75018, France
  536. 536. Hopital Europeen Georges Pompidou, Paris, France
  537. 537. Hopital Robert Debre, Paris, France
  538. 538. INSERM UMR 1137, Paris, France
  539. 539. Vaccine Research Institute (VRI), INSERM UMR 955, Creteil, France
  540. 540. CHU Bordeaux, Bordeaux, France
  541. 541. RENARCI, Annecy, France
  542. 542. CHU Lyon, Lyon, France
  543. 543. REACTing, Paris, France
  544. 544. CHU Nancy, Nancy, France
  545. 545. INSERM CIC-1414, Rennes, France
  546. 546. Hopital la Timone, Marseille, France
  547. 547. Institut Pasteur, Paris, France
  548. 548. Service de Virologie, Universite de Paris, INSERM, IAME, UMR 1137, Hopital Bichat Claude Bernard, AP-HP, Paris, France
  549. 549. IAME INSERM U1140, Hopital Bichat Claude Bernard, AP-HP, Paris, France
  550. 550. Centre d'Investigation Clinique, INSERM CIC 1425, AP-HP, IAME, Paris University, Paris, France
  551. 551. Institut Pasteur, U3569, CNRS, Universite de Paris, Paris, France
  552. 552. IAME INSERM U1138, Hopital Bichat Claude Bernard, AP-HP, Paris, France
  553. 553. Center for Clinical Investigation, Assistance Publique-Hopitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France
  554. 554. Service des Maladies Infectieuses, Centre Hospitalo Universitaire de Cayenne, Guyana
  555. 555. Centre d'Investigation Clinique, INSERM CIC 1424, Centre Hospitalier de Cayenne, Cayenne, Guyana
  556. 556. Service Hopital de Jour Adulte, Centre Hospitalier de Cayenne, Guyana
  557. 557. Centre d'Investigation Clinique, INSERM CIC 1410, Centre Hospitalo Universitaire de la Reunion, La Reunion, France
  558. 558. Centre d'Investigation Clinique, INSERM CIC 1410, CHU Reunion, Reunion Island, Saint-Pierre, Saint Pierre and Miquelon
  559. 559. Centre d'Investigation Clinique, INSERM CIC 1410, Centre de Ressources Biologiques, Centre Hospitalo Universitaire de la Reunion, La Reunion, France
  560. 560. Centre d'Investigation Clinique, INSERM CIC 1414, Centre Hospitalo Universitaire de Rennes, Rennes, France
  561. 561. Service des Maladies Infectieuses, Centre Hospitalo Universitaire de Bordeaux, Bordeaux, France
  562. 562. Centre d'Investigation Clinique, INSERM CIC 1415, CHRU Tours, Tours, France
  563. 563. CRBT, Centre Hospitalo Universitaire de Tours, Tours, France
  564. 564. Pole de Biologie Medicale, Centre Hospitalo Universitaire de Tours, Tours, France
  565. 565. Service des Maladies Infectieuses, Centre Hospitalo Universitaire de Besancon, Besancon, France
  566. 566. Service des Maladies Infectieuses, Centre d'investigation Clinique, INSERM CIC1431, Centre Hospitalier Universitaire de Besancon, Besancon, France
  567. 567. Centre de Ressources Biologiques, Filiere Microbiologique de Besancon, Centre Hospitalier Universitaire, Besancon, France
  568. 568. Universite de Lorraine, CHRU-Nancy and APEMAC, Infectious and Tropical Diseases, Nancy, France
  569. 569. Laboratoire de Virologie, CHRU de Nancy Brabois, Vandoeuvre-les-Nancy, France
  570. 570. INSERM CIC-EC 1433, Centre Hospitalo Universitaire de Nancy, Nancy, France
  571. 571. Centre de Ressources Biologiques, Centre Hospitalo Universitaire de Nancy, Nancy, France
  572. 572. Centre d'Investigation Clinique, INSERM CIC 1408, Centre Hospitalo Universitaire de Saint Etienne, Saint Etienne, France
  573. 573. Service des Maladies Infectieuses, Centre Hospitalo Universitaire de Saint Etienne, Saint Etienne, France
  574. 574. Service des Maladies Infectieuses, CRB42-BTK, Centre Hospitalo Universitaire de Saint Etienne, Saint Etienne, France
  575. 575. Pole Recherche Clinique, INSERM, Paris, France
  576. 576. IMEA Fondation Leon M'Ba, Paris, France
  577. 577. INSERM Clinical Research Department, Paris, France
  578. 578. Department of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands
  579. 579. Department of Infectious Diseases, Amsterdam UMC, Amsterdam, Netherlands
  580. 580. Experimental Immunology, Amsterdam UMC, Amsterdam, Netherlands
  581. 581. Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, Netherlands
  582. 582. Department of Pulmonology, Amsterdam UMC, Amsterdam, Netherlands
  583. 583. Department of Anesthesiology, Amsterdam UMC, Amsterdam, Netherlands
  584. 584. Amsterdam UMC Biobank Core Facility, Amsterdam UMC, Amsterdam, Netherlands
  585. 585. Department of Radiology, Amsterdam UMC, Amsterdam, Netherlands
  586. 586. Department of Medical Microbiology, Amsterdam UMC, Amsterdam, Netherlands
  587. 587. Department of Internal Medicine, Amsterdam UMC, Amsterdam, Netherlands
  588. 588. Neurochemical Laboratory, Amsterdam UMC, Amsterdam, Netherlands
  589. 589. Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, Netherlands
  590. 590. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, Netherlands
  591. 591. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States
  592. 592. NIAID Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States
  593. 593. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, United States
  594. 594. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale, San Gerardo, Monza, Italy
  595. 595. Department of Infectious Diseases, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
  596. 596. CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy
  597. 597. ASST Spedali Civili di Brescia, Brescia, Italy

Source: Science Immunology Published:2021


Abstract

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean, 36.7 years) from a cohort of 1202 male patients aged 0.5 to 99 years (mean, 52.9 years) with unexplained critical COVID-19 pneumonia. None of the 331 asymptomatically or mildly infected male individuals aged 1.3 to 102 years (mean, 38.7 years) tested carry such TLR7 variants (P = 3.5 × 10−5). The phenotypes of five hemizygous relatives of index cases infected with SARS-CoV-2 include asymptomatic or mild infection (n = 2) or moderate (n = 1), severe (n = 1), or critical (n = 1) pneumonia. Two patients from a cohort of 262 male patients with severe COVID-19 pneumonia (mean, 51.0 years) are hemizygous for a deleterious TLR7 variant. The cumulative allele frequency for deleterious TLR7 variants in the male general population is <6.5 × 10−4. We show that blood B cell lines and myeloid cell subsets from the patients do not respond to TLR7 stimulation, a phenotype rescued by wild-type TLR7. The patients’ blood plasmacytoid dendritic cells (pDCs) produce low levels of type I IFNs in response to SARS-CoV-2. Overall, X-linked recessive TLR7 deficiency is a highly penetrant genetic etiology of critical COVID-19 pneumonia, in about 1.8% of male patients below the age of 60 years. Human TLR7 and pDCs are essential for protective type I IFN immunity against SARS-CoV-2 in the respiratory tract. Copyright © 2021
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