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Features and Roles of T Helper 22 Cells in Immunological Diseases and Malignancies Publisher Pubmed



Hosseinkhannazer N1 ; Zian Z2 ; Bakkach J2 ; Kamali AN3, 4 ; Hosseinzadeh R5 ; Anka AU6 ; Yazdani R7 ; Azizi G8
Authors
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Authors Affiliations
  1. 1. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco
  3. 3. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. CinnaGen Research and Production Co, Alborz, Iran
  5. 5. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Laboratory Science, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria
  7. 7. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: Scandinavian Journal of Immunology Published:2021


Abstract

T helper 22 (Th22) cell populations are a newly identified subset of CD4+ T cells that primarily mediate biological effects on the epithelial barrier through interleukin (IL)-22. Although, new studies showed that both Th22 and IL-22 are closely associated with the pathogenesis of inflammatory, autoimmune and allergic disease as well as malignancies. In this review, we aim to describe the development and characteristics of Th22 cells as well as their roles in the immunopathogenesis of immune-related disorders and cancer. © 2021 The Scandinavian Foundation for Immunology
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