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Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications Publisher



Gorabi AM1 ; Kiaie N1 ; Hajighasemi S2 ; Banach M3, 4 ; Penson PE5 ; Jamialahmadi T6, 7 ; Sahebkar A8, 9, 10
Authors
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Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, 1411713138, Iran
  2. 2. Department of Medical Biotechnology, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin, 1531534199, Iran
  3. 3. Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, 93-338, Poland
  4. 4. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, 93-338, Poland
  5. 5. School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom
  6. 6. Halal Research Center of IRI, FDA, Tehran, 1411713138, Iran
  7. 7. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  8. 8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  9. 9. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  10. 10. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran

Source: Journal of Clinical Medicine Published:2019


Abstract

In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
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