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Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones Publisher



Mahdavi M1 ; Asadi M2 ; Khoshbakht M3 ; Saeedi M4, 5 ; Bayat M3 ; Foroumadi A2 ; Shafiee A2
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Source: Helvetica Chimica Acta Published:2016


Abstract

A series of novel quinazolin-4(3H)-one derivatives were efficiently synthesized starting from isatoic anhydride. First, reaction of isatoic anhydride and amines in H2O at room temperature afforded 2-aminobenzamides. Then, CuBr/Et3N promoted reaction of 2-aminobenzamides and different aryl isothiocyanates in DMF at 80° afforded the title compounds in good yield. © 2016 Verlag Helvetica Chimica Acta AG, Zurich.
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