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The Roles of Quercetin in Diabetes Mellitus and Related Metabolic Disorders; Special Focus on the Modulation of Gut Microbiota: A Comprehensive Review Publisher Pubmed

Summary: Quercetin, found in many fruits and vegetables, may help manage diabetes and metabolic disorders by improving gut health and reducing oxidative stress. Include quercetin-rich foods like apples, berries, and onions in your diet. More research is needed.

Roshanravan N1 ; Askari SF2, 3 ; Fazelian S4 ; Ayati MH5, 6 ; Namazi N7
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Authors Affiliations
  1. 1. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
  3. 3. Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran
  4. 4. Clinical Research Development Unit, Ayatollah Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Critical Reviews in Food Science and Nutrition Published:2023


Abstract

Quercetin is a dietary flavonoid that can affect the balance between anti-oxidant defense system and oxidative stress. A number of studies showed the positive effects of quercetin on diabetes mellitus and related metabolic disorders through different pathways such as gut flora. However, findings are conflicting. In addition, it seems no studies have summarized all potential mechanisms of quercetin in diabetes mellitus, so far. Therefore, the aims of the present comprehensive review were to provide an overview on biological and biochemical characteristics of quercetin and investigate the effect of quercetin on diabetes mellitus and related metabolic disorders by focusing on its effects on the modulation of gut microbiota. For this purpose, findings of In vitro, animal studies, clinical trials, and review studies with the English language published until January 2021 were summarized. They were identified through electronic databases (PubMed, Scopus, and Cochrane Library) and Google Scholar. Findings showed that quercetin can be an effective component for improving glycemic status and other metabolic disorders related to diabetes mellitus based on In vitro and animal studies. However, environmental factors, food processing and using nanoformulations can affect its efficacy in human studies. Several potential mechanisms, including the modulation of gut flora are proposed for its actions. However, due to limited clinical trials and contradictory findings, more high-quality clinical trials are needed to make a decision on the efficacy of supplementation with quercetin as a complementary therapy for the management of diabetes mellitus, metabolic disorders, and modulating gut flora. © 2021 Taylor & Francis Group, LLC.
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