Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones

Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones Publisher

Mohammadhosseini N¹ ; Saeedi M^{2, 3} ; Moradi S¹ ; Mahdavi M⁵ ; Firuzi O⁴ ; Foroumadi A⁵ ; Shafiee A⁵

Show Affiliations

1. Faculty of Chemistry, Tehran-North Branch, Islamic Azad University, Tehran, Iran
2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Medicinal and Natural Product Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Turkish Journal of Chemistry Published:2017

Abstract

Various thioxo-quinazolino[3,4-a]quinazolinones were prepared and evaluated for their cytotoxicity in MOLT-4 (lymphoblastic leukemia) and MCF-7 (breast adenocarcinoma) cell lines. Synthesis of the target compounds was started from isatoic anhydride. Successive reaction of isatoic anhydride with benzylamine and 2-nitrobenzaldehyde, reduction of the nitro group, and reaction with CS2 gave 12-benzyl-6-thioxo-6,7,11b,12-tetrahydro-13H-quinazolino[3,4-a]quinazolin-13-one. The latter compound reacted with various 2-chloro-N-substituted acetamides to afford the corresponding fused quinazolinone derivatives. © TUBITAK.

Style	Citing Format
MLA	Mohammadhosseini N, et al.. "Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones." Turkish Journal of Chemistry, vol. 41, no. 1, 2017, pp. 125-134.
APA	Mohammadhosseini N, Saeedi M, Moradi S, Mahdavi M, Firuzi O, Foroumadi A, Shafiee A (2017). Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones. Turkish Journal of Chemistry, 41(1), 125-134.
Chicago	Mohammadhosseini N, Saeedi M, Moradi S, Mahdavi M, Firuzi O, Foroumadi A, Shafiee A. "Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones." Turkish Journal of Chemistry 41, no. 1 (2017): 125-134.
Harvard	Mohammadhosseini N et al. (2017) 'Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones', Turkish Journal of Chemistry, 41(1), pp. 125-134.
Vancouver	Mohammadhosseini N, Saeedi M, Moradi S, Mahdavi M, Firuzi O, Foroumadi A, et al.. Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones. Turkish Journal of Chemistry. 2017;41(1):125-134.
BibTex	@article{ author = {Mohammadhosseini N and Saeedi M and Moradi S and Mahdavi M and Firuzi O and Foroumadi A and Shafiee A}, title = {Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones}, journal = {Turkish Journal of Chemistry}, volume = {41}, number = {1}, pages = {125-134}, year = {2017} }
RIS	TY - JOUR AU - Mohammadhosseini N AU - Saeedi M AU - Moradi S AU - Mahdavi M AU - Firuzi O AU - Foroumadi A AU - Shafiee A TI - Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones JO - Turkish Journal of Chemistry VL - 41 IS - 1 SP - 125 EP - 134 PY - 2017 ER -

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