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Carboxymethylated Polysaccharides in Drug Delivery Publisher



Zarrintaj P1 ; Ganjali MR2, 3 ; Salmankhani A4 ; Mashhadzadeh AH5 ; Munir MT6, 7 ; Salehnia F2 ; Rezapour M8 ; Habibzadeh S9 ; Saeb MR10
Authors
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Authors Affiliations
  1. 1. School of Chemical Engineering, Oklahoma State University, Stillwater, OK, United States
  2. 2. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  3. 3. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran
  5. 5. Department of Mechanical and Aerospace Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan, Kazakhstan
  6. 6. College of Engineering and Technology, American University of the Middle East, Egaila, Kuwait
  7. 7. Department of Chemical and Materials Engineering, The University of Auckland, Auckland, New Zealand
  8. 8. IP Department, Research Institute of Petroleum Industry (RIPI), Tehran, Iran
  9. 9. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  10. 10. Department of Polymer Technology, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland

Source: Tailor-Made Polysaccharides in Drug Delivery Published:2022


Abstract

Drug delivery materials are complex in nature and need a wide variety of requirements from smart to classical design protocols. In this regard, the selection of materials is important. Based on the literature, considerable potential of natural polymers such as polysaccharides and their derivatives for drug delivery applications has been identified quite high. Therefore, finding novel routes of enhancing their performance has become an impotent branch of science in biomaterials and medicine. Due to the inevitable necessity, a wide variety of pristine polysaccharides have been examined; besides, a wide variety of chemical modification techniques have been developed. As a well-documented strategy, carboxymethylation (defined as introduction of a carboxymethyl group into a compound) has received great attention from researchers, which led to promising outcomes. Carboxymethylated polysaccharides with improved solubility and physicochemical properties have been continually synthesized and underwent innovative developing periods and many scientists recommended such derivatives of polysaccharides for drug delivery systems. These polysaccharides bearing cationic charges were found to be able to physically become cross-linked via electrostatic and ionic interaction with the polycationic species, small molecules, and metal ions to induce integrity. In this chapter, we have fully considered the principles and applications of drug delivery platforms based on carboxymethylated polysaccharides. We have outlined the results obtained by the most recent research outputs and tried to give a vivid direction to those seeking design of carboxymethyl polysaccharides by classifying researches carried out. As the main outcome of the present review, we attempted to highlight drug carriers obtained from ionically cross-linked carboxymethylated polysaccharides as promising candidates for delivery of various drugs such as chemotherapeutics, antiinflammatory drugs, and protein-based therapeutic agents. © 2023 Elsevier Inc. All rights reserved.
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