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Burden of Neurodegenerative Diseases in the Eastern Mediterranean Region, 1990–2016: Findings From the Global Burden of Disease Study 2016 Publisher Pubmed



Fereshtehnejad SM1, 2, 3 ; Vosoughi K4 ; Heydarpour P5 ; Sepanlou SG6 ; Farzadfar F7 ; Tehranibanihashemi A8 ; Malekzadeh R6 ; Sahraian MA5 ; Vollset SE9, 11 ; Naghavi M9 ; Vos T9 ; Feigin V10 ; Murray C9 ; Mokdad AH9 Show All Authors
Authors
  1. Fereshtehnejad SM1, 2, 3
  2. Vosoughi K4
  3. Heydarpour P5
  4. Sepanlou SG6
  5. Farzadfar F7
  6. Tehranibanihashemi A8
  7. Malekzadeh R6
  8. Sahraian MA5
  9. Vollset SE9, 11
  10. Naghavi M9
  11. Vos T9
  12. Feigin V10
  13. Murray C9
  14. Mokdad AH9
  15. Moradilakeh M8
Show Affiliations
Authors Affiliations
  1. 1. Division of Neurology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
  2. 2. Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
  3. 3. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden
  4. 4. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Community Medicine, Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Institute for Health Metrics and Evaluation (IHME), University of Washington, Seattle, WA, United States
  10. 10. National Institute for Stroke and Applied Neurosciences, Auckland University of Technology, Auckland, New Zealand
  11. 11. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway

Source: European Journal of Neurology Published:2019


Abstract

Background and purpose: The Eastern Mediterranean Region (EMR) is experiencing a demographic shift towards rapid aging at a time of political unrest. We aimed to estimate the burden of neurodegenerative disorders and its relationship with sociodemographic index in the EMR countries from 1990 to 2016. Methods: Using data from the Global Burden of Disease Study 2016, we calculated country-specific trends for prevalence, mortality, disability-adjusted life-years (DALY), years of life lost and years lived with disability (YLD) for Alzheimer's disease/other dementias and Parkinson's disease in the EMR during 1990–2016. Results: In the EMR, the age-standardized prevalence rate of Alzheimer's disease/other dementias and Parkinson's disease was estimated at 759.8/100 000 (95% uncertainty intervals, 642.9–899.9) and 87.1/100 000 (95% uncertainty intervals, 69.8–108.2) people in 2016, demonstrating 0.01% and 42.3% change from 1990, respectively. Neurodegenerative disorders contributed to 5.4% of total DALY and 4.6% of total YLD among the older EMR population (70 years of age or older in 2016). Age-standardized DALY due to Parkinson's disease were strongly correlated with the sociodemographic index level (r = 0.823, P < 0.001). The YLD:DALY ratio of neurodegenerative diseases declined during this period in the low-income but not the high-income EMR countries. Conclusions: Our findings demonstrated an increasing trend in the burden of dementias and Parkinson's disease in most EMR countries between 1990 and 2016. With aging of the EMR populations, countries should target the modifiable risk factors of neurodegenerative diseases to control their increasing burden. © 2019 EAN
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