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Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application Publisher



Nikbakht M1 ; Karbasi S2 ; Rezayat SM1, 3
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technology in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Biomaterials and Tissue Engineering, School of Advanced Technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Materials Technology Published:2020


Abstract

This study aimed to develop a nanocomposite scaffold using electrospinning of Poly (3-hydroxybutyrate) (PHB), Chitosan (Cs), Multi Wall Carbon Nanotubes (MWNTs), and different concentrations of Hyaluronic Acid (HA). The results showed that an increasing in HA concentration from 0 to 15%wt significantly increased the nanofibers diameter and hydrophilicity and insignificantly decreased the porosity and tensile strength of the nanocomposite scaffolds. The bioactivity and biodegradation assessment showed that PHB-Cs-MWNTs-HA 15% scaffold has proper bioactivity and biodegradability. These findings indicated that the incorporation of HA increased the hydrophilicity, and subsequently enhanced the biodegradation and the bioactivity of the nanocomposite scaffolds. In vitro cell culture studies showed that chondrocytes were able to attach onto the surface of electrospun scaffolds. These results clearly implied that the fabricated nanofibers can be effectively used as the cartilage tissue engineering and HA has positive effects on the biological properties of the nanocomposite scaffolds. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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