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Status and Future Scope of Plant-Based Green Hydrogels in Biomedical Engineering Publisher



Mohammadinejad R1 ; Maleki H2 ; Larraneta E3 ; Fajardo AR4 ; Nik AB5 ; Shavandi A6 ; Sheikhi A7, 8, 9, 10, 11 ; Ghorbanpour M12 ; Farokhi M13 ; Govindh P14 ; Cabane E15, 16 ; Azizi S17 ; Aref AR18 ; Mozafari M19, 20, 21 Show All Authors
Authors
  1. Mohammadinejad R1
  2. Maleki H2
  3. Larraneta E3
  4. Fajardo AR4
  5. Nik AB5
  6. Shavandi A6
  7. Sheikhi A7, 8, 9, 10, 11
  8. Ghorbanpour M12
  9. Farokhi M13
  10. Govindh P14
  11. Cabane E15, 16
  12. Azizi S17
  13. Aref AR18
  14. Mozafari M19, 20, 21
  15. Mehrali M22
  16. Thomas S14
  17. Mano JF23
  18. Mishra YK24
  19. Thakur VK25, 26
Show Affiliations
Authors Affiliations
  1. 1. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Institute of Inorganic Chemistry, Department of Chemistry, University of Cologne, Greinstrasse 6, Cologne, 50939, Germany
  3. 3. School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, Selangor, United Kingdom
  4. 4. Laboratorio de Tecnologia e Desenvolvimento de MateriaisPolimericos e Compositos - LaCoPol. Centro de CienciasQuimicas, Farmaceuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), Pelotas, 96010-900, RS, Brazil
  5. 5. Department of Biomedical Engineering, Florida International University, Miami, 33174, FL, United States
  6. 6. BioMatter unit-Biomass transformation Lab (BTL), Ecole interfacultaire de Bioingenieurs (EIB), Ecole polytechnique de Bruxelles, Universite Libre de Bruxelles, Avenue F.D. Roosevelt, 50- CP 165/61, Brussels, 1050, Belgium
  7. 7. Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, 90095, CA, United States
  8. 8. Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, 90095, CA, United States
  9. 9. >California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, 90095, CA, United States
  10. 10. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, 02139, MA, United States
  11. 11. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02139, MA, United States
  12. 12. Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak, 38156-8-8349, Iran
  13. 13. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  14. 14. International Inter-University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, India
  15. 15. Wood Materials Science, ETH Zurich, Stefano-Franscini-Platz 3, Zurich, 8093, Switzerland
  16. 16. Applied Wood Materials, EMPA - Swiss Federal Laboratories for Materials Science and Technology, Uberlandstrasse 129, Dubendorf, 8600, Switzerland
  17. 17. Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, 43400, Selangor, Malaysia
  18. 18. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02215, MA, United States
  19. 19. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  20. 20. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  21. 21. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  22. 22. Department of Health Technology, Center for Intestinal Absorption and Transport of Biopharmaceuticals, Technical University of Denmark, Lyngby, 2800 Kgs., Denmark
  23. 23. Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, 3810-193, Portugal
  24. 24. Functional Nanomaterials, Institute for Materials Science, Kiel University, Kaiserstr. 2, Kiel, D-24143, Germany
  25. 25. Enhanced Composites and Structures Center, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedfordshire, MK43 0AL, United Kingdom
  26. 26. Department of Mechanical Engineering, School of Engineering, Shiv Nadar University, 201314, Uttar Pradesh, India

Source: Applied Materials Today Published:2019


Abstract

Hydrogels are the most iconic class of soft materials, and since their first report in the literature, they have attracted the attention of uncountable researchers. Over the past two decades, hydrogels have become smart and sophisticated materials with numerous applications. This class of soft materials have been playing a significant role in biomedicine due to their tunable and often programmable properties. Hydrogels from renewable polymers have been popularized in biomedical applications as they are often biocompatible, easily accessible, and inexpensive. The challenge however has been to find an ideal plant-based hydrogel for biomedicine that can mimic critical properties of human tissues in terms of structure, function, and performance. In addition, natural polymers can readily be functionalized to engineer their chemical and physical uproperties pertinent to drug delivery and tissue engineering. Here, the most recent advances in the synthesis, fabrication, and applications of plant-based hydrogels in biomedical engineering are reviewed. We cover essential and updated information about plants as green sources of biopolymers for hydrogel synthesis, general aspects of hydrogels and plant-based hydrogels, and thorough discussion regarding the use of such hydrogels in the biomedical engineering area. Furthermore, this review details the present status of the field and answers several important questions about the potential of plant-based hydrogels in advanced biomedical applications including therapeutics, tissue engineering, wound dressing, and diagnostics., etc. © 2019 Elsevier Ltd
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