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Modulation of the Effects of the Cannabinoid Agonist, Acpa, on Spatial and Non-Spatial Novelty Detection in Mice by Dopamine D1 Receptor Drugs Infused Into the Basolateral Amygdala Publisher Pubmed



Mohammadi M1 ; Nasehi M2 ; Zarrindast MR1, 3, 4, 5
Authors
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Authors Affiliations
  1. 1. Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  2. 2. Medical Genomics Research Centerand School of Advanced Sciences in Medicine, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran
  3. 3. Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran

Source: Behavioural Brain Research Published:2015


Abstract

Aim: The amygdala is a major target of midbrain dopaminergic neurons and is implicated in learning and memory processes. This study investigates the effect of basolateral amygdale (BLA) dopamine receptors on spatial and non-spatial novelty detection deficit, induced by a selective CB1 cannabinoid receptor agonist (Arachidonylcyclopropylamide; ACPA), during a non-associative task. Methods: Male mice weighing 30-35. g were used. Open field procedure was employed to assess the spatial and non-spatial memory retention. Results: Our data showed that post-training intraperitoneal injection of ACPA (0.02. mg/kg), intra-BLA microinjection of SKF38393 (D1 dopamine receptor agonist; at higher dose, 0.1. μg/mouse) and SCH23390 (D1 dopamine receptor antagonist; at lowest dose, 0.005. μg/mouse) impaired both spatial and non-spatial novelty detection. Moreover, intra-BLA microinjection of subthreshold dose of SKF38393 or SCH23390 restored and potentiated the spatial and non-spatial novelty detection impairment caused by ACPA, respectively. Conclusion: Our results suggested that the ACPA induced impairment of memory retention, may occur through BLA D1 dopamine receptors. © 2014 Elsevier B.V.
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