Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Effects of Nano-Biphasic Calcium Phosphate Composite on Bioactivity and Osteoblast Cell Behavior in Tissue Engineering Applications Publisher



Ebrahimianhosseinabadi M1 ; Etemadifar M2 ; Ashrafizadeh F3
Authors

Source: Journal of Medical Signals and Sensors Published:2016


Abstract

In this paper, preparation, bioactivity, and osteoblast cell behavior of cortical bone derived nano-biphasic calcium phosphate (nano-BCP) are presented. The calcined bovine bone samples with the addition of di-ammonium hydrogen phosphate were heated at 700°C for 100 min, and thus nano-BCP with the composition of 63/37 hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) was produced. Scanning electron microscopy (SEM) images, energy dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD) analysis of immersed samples in simulated body fluid (SBF) solution showed that a uniform layer was formed on the surface after 7 days with the chemical composition of HA. The results indicated that the nano-BCP sample developed excellent bioactivity after 28 days. The nano-BCP samples showed better cell proliferation compared to pure HA samples. After 7 days in cell culture, the prepared nano-BCP (HA/β-TCP) exhibited the maximum proliferation of the MG-63 osteoblast cells. © 2016 Journal of Medical Signals and Sensors.
Related Docs
View other Related Docs
1. Natural Hydroxyapatite/Diopside Nanocomposite Scaffold for Bone Tissue Engineering Applications: Physical, Mechanical, Bioactivity and Biodegradation Evaluation, Materials Technology (2022)
2. Preparation and Mechanical Behavior of Plga/Nano-Bcp Composite Scaffolds During In-Vitro Degradation for Bone Tissue Engineering, Polymer Degradation and Stability (2011)
3. Fabrication and Characterization of 3D-Printed Composite Scaffolds of Coral-Derived Hydroxyapatite Nanoparticles/Polycaprolactone/Gelatin Carrying Doxorubicin for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2024)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (5)
Ali Poursamar (2)
Other Related Docs
4. Fabrication and Characterization of Porous Co-Cr-Mo/58S Bioglass Nano-Composite by Using Nh4hco3 As Space-Holder, Materials and Design (2015)
5. Sol-Gel Derived Mesoporous 45S5 Bioactive Glass Containing Mg and Zr Ions: Synthesis, Characterization, and in Vitro Biological Investigation, Arabian Journal of Chemistry (2024)
6. Effect of Cao Additive on the Properties of Plasma Electrolytic Oxidation Coatings on Az31 Mg Alloy, Journal of Materials Engineering and Performance (2025)
7. Direct Cytotoxicity Evaluation of 63S Bioactive Glass and Bone-Derived Hydroxyapatite Particles Using Yeast Model and Human Chondrocyte Cells by Microcalorimetry, Journal of Materials Science: Materials in Medicine (2011)
8. Cytotoxicity Evaluation of 63S Bioactive Glass and Bone-Derived Hydroxyapatite Particles Using Human Bone-Marrow Stem Cells, Biomedical Papers (2011)
9. A Femoral Shape Porous Scaffold Bio-Nanocomposite Fabricated Using 3D Printing and Freeze-Drying Technique for Orthopedic Application, Materials Chemistry and Physics (2022)
10. Nano-Biphasic Calcium Phosphate Ceramic for the Repair of Bone Defects, Journal of Craniofacial Surgery (2018)
11. Synthesis and Characterization of Nanosized Magnesium-Doped Fluorapatite Powder and Coating for Biomedical Application, Journal of Sol-Gel Science and Technology (2015)
12. Evaluating and Modeling the Mechanical Properties of the Prepared Plga/Nano-Bcp Composite Scaffolds for Bone Tissue Engineering, Journal of Materials Science and Technology (2011)
13. Bone Repair With Differentiated Osteoblasts From Adipose-Derived Stem Cells in Hydroxyapatite/Tricalcium Phosphate in Vivo, International Journal of Preventive Medicine (2016)
14. Morphology and Degradation of Poly (3-Hydroxybutyrate)/ Nano-Hydroxyapatite Scaffold Used in Tissue Engineering, Journal of Isfahan Medical School (2012)
15. Structural Comparison of Natural and Synthetic Nanocrystalline Hydroxyapatite, Journal of Isfahan Medical School (2012)
16. Preparation and Characterization of Hydroxyapatite Nanoparticles Doped With Nickel, Tin, and Molybdate Ions for Their Antimicrobial Effects, Drug Development and Industrial Pharmacy (2023)
17. Synthesis and in Vitro Evaluation of Electrodeposited Barium Titanate Coating on Ti6al4v, Journal of Medical Signals and Sensors (2016)
18. The Influence of Bioglass Nanoparticles on the Biodegradation and Biocompatibility of Poly (3-Hydroxybutyrate) Scaffolds, International Journal of Artificial Organs (2012)
19. Magnesium/Nano-Hydroxyapatite Porous Biodegradable Composite for Biomedical Applications, Materials Research Express (2019)
20. Synthesis and Dissolution Behavior of Nanosized Silicon and Magnesium Co-Doped Fluorapatite Obtained by High Energy Ball Milling, Ceramics International (2014)