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A Review of Highly Sensitive Electrochemical Genosensors for Microrna Detection: A Novel Diagnostic Platform for Neurodegenerative Diseases Diagnostics Publisher Pubmed



Azimi Sanavi M1 ; Mahdavian F2 ; Dorosti N3 ; Karami N4 ; Karami S5 ; Khatami SH6 ; Vakili O7 ; Taherianganeh M8 ; Karima S6 ; Movahedpour A9
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry and Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Department of Medical Biotechnology, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Sari, Iran
  4. 4. TU Wien, Institute of Solid State Electronics, Vienna, Austria
  5. 5. Department of Chemistry, Shiraz University, Shiraz, Iran
  6. 6. Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran
  9. 9. Behbahan Faculty of Medical Sciences, Behbahan, Iran

Source: Biotechnology and Applied Biochemistry Published:2023


Abstract

The significant role of microRNAs in regulating gene expression and in disease tracking has handed the possibility of robust and accurate diagnosis of various diseases. Measurement of these biomarkers has also had a significant impact on the preparation of natural samples. Discovery of miRNAs is a major challenge due to their small size in the real sample and their short length, which is generally measured by complex and expensive methods. Electrochemical nanobiosensors have made significant progress in this field. Due to the delicate nature of nerve tissue repair and the significance of rapid-fire feature of neurodegenerative conditions, these biosensors can be reliably promising. This review presents advances in the field of neurodegenerative diseases diagnostics. At the same time, there are still numerous openings in this field that are a bright prospect for researchers in the rapid-fire opinion of neurological diseases and indeed nerve tissue repair. © 2022 International Union of Biochemistry and Molecular Biology, Inc.
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