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Effect of Hydro-Alcoholic Extract of Nigella Sativa on Cisplatin-Induced Memory Impairment and Brain Oxidative Stress Status in Male Rats Publisher



Janloo YM1 ; Attari FS1 ; Roshan S1 ; Lotfi H2 ; Pezeshki AH3 ; Hosseinzadeh M1 ; Shakibajam B1 ; Kafami M4, 5
Authors
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Authors Affiliations
  1. 1. Student Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  2. 2. Leishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  3. 3. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Non-Communicable Disease Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  5. 5. Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

Source: Avicenna Journal of Phytomedicine Published:2024


Abstract

Objective: Studies have shown the complications of chemotherapy on learning and memory. Empirical evidence suggests that Nigella sativa (NS) has neuroprotective activities. Therefore, the aim of our study was to investigate the effects of NS on cisplatin-induced memory impairment. Materials and Methods: This study was conducted on 40 male rats grouped as: control (saline: 2 ml/kg, intraperitoneally (IP), once weekly/2 weeks), cisplatin (Cis, 2 mg/kg, IP, once weekly/2 weeks), NS (200 mg/kg, IP, once weekly/2 weeks), Cis +NS 200 (2 mg/kg Cis + 200 mg/kg NS, IP, once weekly/2 weeks), and Cis +NS 400 (2 mg/kg Cis + 400 mg/kg NS, IP, once weekly/2 weeks). Morris water maze (MWM) test was used to assess spatial learning and memory. In addition, superoxide dismutase (SOD) activity, and thiol and malondialdehyde (MDA) levels were evaluated in the brain. Results: Cis significantly enhanced the traveled distance and time spent in the target quadrant in the MWM test. Additionally, MDA levels increased in the Cis group, while thiol and SOD decreased in this group. As a result of treatment with NS, behavioral results were reversed in the groups receiving NS compared to the Cis group. Also, NS reduced MDA level but improved SOD and thiol levels in brain tissue samples. Conclusion: NS could improve memory impairment and oxidative stress in animals receiving Cis. Therefore, NS could be used as a potential food supplement to prevent neurotoxicity in patients undergoing chemotherapy. © 2024 Mashhad University of Medical Sciences. All rights reserved.
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