Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Probiotic Yogurt Consumption on Intestinal Permeability in Inflammatory Bowel Disease: A Double-Blind Randomized Clinical Trial



Shadnoush M1 ; Nazari M2 ; Hajianfar H3 ; Faghfoori Z2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition Sciences & Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Food Safety research center (Salt), Semnan University of Medical Sciences, Semnan, Iran
  3. 3. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical sciences, Isfahan, Iran

Source: Koomesh Published:2021

Abstract

Introduction: Disorders in intestinal permeability have been reported in the pathophysiology of inflammatory bowel diseases (IBD) that may be compensated by complementary therapies through modifying the composition of the intestinal microflora. This study was designed to evaluate the effect of probiotic yogurt on intestinal permeability in patients with IBD. Materials and Methods: In this double-blind randomized clinical trial, 86 patients in the probiotic yogurt group (intervention patient), 90 patients in the plain yogurt group (control patient) and 84 volunteers in healthy control group receiving 250 g of commercial probiotic/plain yogurt daily for 8 weeks. At the end of the eighth week, a lactulose/mannitol ratio (LMR) test was used to assess intestinal permeability. Results: The mean age of participants in the study was 37.7 years and the mean body mass index in all subjects was 24.17 ± 2.65 kg/ m2. There was no significant difference in the LMR of the intervention group and control patient group at the beginning of the study (P=0.08) However, at the end of the period, this ratio decreased significantly in the intervention group compared to the control patient group (P=0.023). Importantly, this indicator in the healthy control group in comparison with intervention group was significantly lower at the beginning and at the end of the study. Conclusion: The results of the present study showed that probiotics consumption via diet such as its use in dairy products such as yogurt can be a good way to improve gastrointestinal damage, including improving the permeability of the intestine and prevent or repair mucosal damage. © 2021, Semnan University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. The Effects of Probiotics in Ulcerative Colitis Patients: A Randomized Controlled Double Blind Clinical Trial, Functional Foods in Health and Disease (2023)
2. The Effects of Probiotic/Synbiotic on Serum Level of Zonulin As a Biomarker of Intestinal Permeability: A Systematic Review and Meta-Analysis, Iranian Journal of Public Health (2020)
3. Effect of Enteral Probiotics on Prognostic Scores and C-Reactive Protein Levels in Critically Ill Multiple Trauma Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Clinical Nutrition ESPEN (2023)
4. Is Dairy Foods Restriction Mandatory for Inflammatory Bowel Disease Patients: A Multinational Cross-Sectional Study; [Restricao De Alimentos Lacteos E Obrigatoria Para Pacientes Com Doenca Inflamatoria Intestinal? Estudo Transversal Multinacio-Nal. Arq Gastroenterol.], Arquivos de Gastroenterologia (2022)
5. Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials, Digestive Diseases and Sciences (2024)
6. The Efficacy of a Synbiotic Containing Bacillus Coagulans in Treatment of Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial, Gastroenterology and Hepatology from Bed to Bench (2014)
7. The Effects of Probiotic Supplementation on Functional Constipation Following Colonoscopy: A Double-Blinded Randomized Controlled Trial, Current Nutrition and Food Science (2025)
8. Effects of Soy Milk Consumption on Gut Microbiota, Inflammatory Markers, and Disease Severity in Patients With Ulcerative Colitis: A Study Protocol for a Randomized Clinical Trial, Trials (2020)
Experts (# of related papers)
View all Related Experts
Peyman Adibi (21)
Hamed Daghaghzadeh (6)
Other Related Docs
9. Systematic Review With Meta-Analysis: Effects of Probiotic Supplementation on Symptoms in Functional Dyspepsia, Journal of Functional Foods (2020)
10. The Effect of Daily Consumption of Probiotic Yogurt on Liver Enzymes, Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease (Nafld): Study Protocol for a Randomized Clinical Trial, BMC Gastroenterology (2022)
11. A Randomized Controlled Trial Investigating the Effect of a Diet Low in Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols on the Intestinal Microbiome and Inflammation in Patients With Ulcerative Colitis: Study Protocol for a Randomized Controlled Trial, Trials (2020)
12. Metabolomics Analysis Revealed Metabolic Changes in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Metabolic Responses to a Synbiotic Yogurt Intervention, European Journal of Nutrition (2019)
13. Serologic Celiac Disease in Patients With Inflammatory Bowel Disease, Journal of Research in Medical Sciences (2012)
14. The Association of Ultra-Processed Food Consumption With Adult Inflammatory Bowel Disease Risk: A Systematic Review and Dose-Response Meta-Analysis of 4 035 694 Participants, Nutrition Reviews (2024)
15. Irritable Bowel Syndrome-Like Symptoms in Patients With Inflammatory Bowel Disease in Clinical Remission Phase Are Related to Gut Inflammation, Journal of Research in Medical Sciences (2012)
16. Evaluation and Comparison of Therapeutic Effects of Probiotics and Colloidal Bismuth Subcitrate on Abdominal Bloating, Caspian Journal of Internal Medicine (2023)
17. Association Between Inflammatory Potential of the Diet and Ulcerative Colitis: A Case-Control Study, Frontiers in Nutrition (2021)
18. Efficacy of Low-Fat Milk and Yogurt Fortified With Vitamin D3 on Systemic Inflammation in Adults With Abdominal Obesity, Journal of Health, Population and Nutrition (2022)
19. Comparing the Efficacy of Two Drugs Senalin and Bisacodyl in Treatment of Constipation in Intensive Care Units’ Patients, Advanced Biomedical Research (2019)
20. Effects of Probiotic Supplementation in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis, Nutrition Reviews (2016)
21. The Effects of Probiotics on Body Weight and Biomarkers of Animal, Pakistan Journal of Nutrition (2013)
22. Technology and Potential Applications of Probiotic Encapsulation in Fermented Milk Products, Journal of Food Science and Technology (2015)
23. A Systematic Review and Meta-Analysis of Prevalence and Clinical Features of Upper Gastrointestinal (Ugi) Tract Crohn's Disease in Adults Compared to Non-Ugi Types, JGH Open (2023)
24. The Role of Probiotic Supplementation in Inflammatory Biomarkers in Adults: An Umbrella Meta-Analysis of Randomized Controlled Trials, Inflammopharmacology (2023)
25. Effects of Spirulina Supplementation in Patients With Ulcerative Colitis: A Double-Blind, Placebo-Controlled Randomized Trial, BMC Complementary Medicine and Therapies (2024)
26. Adherence to a Low Fodmap Diet in Relation to Symptoms of Irritable Bowel Syndrome in Iranian Adults, Digestive Diseases and Sciences (2018)
27. The Effect of Pumpkin and Probiotic Yogurt Consumption Separately Or/And Simultaneously on Type Ii Diabetes, Journal of Isfahan Medical School (2014)
28. Effects of Vitamin D Supplementation on Serum 25‑Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta‑Analysis of Randomized Clinical Trials, International Journal of Preventive Medicine (2024)
29. The Association Between Dietary Total Antioxidant Capacity and Odds and Severity of Irritable Bowel Syndrome Among Iranian Adults: A Cross-Sectional Study, BMC Gastroenterology (2022)
30. Comparison and Assessment of Flixweed and Fig Effects on Irritable Bowel Syndrome With Predominant Constipation: A Single-Blind Randomized Clinical Trial, Explore (2019)
31. Melatonin Supplementation in Preclinical Colitis Models: A Systematic Review and Dose-Response Meta-Analysis on Inflammation, Oxidative Stress, and Colon Repair, PharmaNutrition (2024)
32. Association of Ultra-Processed Food Intake With Risk of Inflammatory Bowel Disease: Prospective Cohort Study, The BMJ (2021)
33. Impact of Probiotics on Gastrointestinal Function and Metabolic Status After Roux-En-Y Gastric Bypass: A Double-Blind, Randomized Trial, Obesity Surgery (2024)
34. Consumption of a Low Fermentable Oligo‑, Di‑, Mono‑Saccharides, and Polyols Diet and Irritable Bowel Syndrome: A Systematic Review, International Journal of Preventive Medicine (2017)
35. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Clinical Trials, Nutrition Reviews (2025)
36. The Effects of Supplementation With Probiotic on Biomarkers of Oxidative Stress in Adult Subjects: A Systematic Review and Meta-Analysis of Randomized Trials, Probiotics and Antimicrobial Proteins (2020)
37. Lactose-Free Compared With Lactose-Containing Formula in Dietary Management of Acute Childhood Diarrhea, Iranian Journal of Pediatrics (2012)
38. The Effect of Probiotics on Inflammatory Biomarkers: A Meta-Analysis of Randomized Clinical Trials, European Journal of Nutrition (2020)
39. Comparison of Lactobacillus Sporogenes Plus Mineral Oil and Mineral Oil Alone in the Treatment of Childhood Functional Constipation, Journal of Research in Medical Sciences (2013)
40. Production and Evaluation of a Probiotic Yogurt Using Lactobacillus Casei Ssp. Casei, International Journal of Dairy Technology (2009)
41. Food Allergy Among Iranian Children With Inflammatory Bowel Disease: A Preliminary Report, Journal of Research in Medical Sciences (2015)
42. The Relationship Between Intestinal Parasites and Some Immune-Mediated Intestinal Conditions, Gastroenterology and Hepatology from Bed to Bench (2015)
43. Effects of Probiotics on Salivary Cytokines and Immunoglobulines: A Systematic Review and Meta-Analysis on Clinical Trials, Scientific Reports (2020)
44. Probiotic Consumption and Inflammatory Markers in Athletes: A Systematic Review and Meta-Analysis, International Journal of Food Properties (2020)
45. Adherence to the Pro-Inflammatory Diet in Relation to Prevalence of Irritable Bowel Syndrome, Nutrition Journal (2019)
46. The Effect of Fermented Dairy Intake and Abdominal Obesity in Adults: A Systematic Review and Dose–Response Meta-Analysis of Cohort Studies, Eating and Weight Disorders (2025)
47. Association of Dietary Fiber, Fruit, and Vegetable Consumption With Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis, Advances in Nutrition (2021)
48. Effect of Probiotic Soy Milk on Serum Levels of Adiponectin, Inflammatory Mediators, Lipid Profile, and Fasting Blood Glucose Among Patients With Type Ii Diabetes Mellitus, Probiotics and Antimicrobial Proteins (2017)
49. Empirically Derived Food-Based Inflammatory Potential of the Diet, Irritable Bowel Syndrome, and Its Severity, Nutrition (2019)
50. The Effect of Biofeedback Therapy on Dyssynergic Constipation in Patients With or Without Irritable Bowel Syndrome, Journal of Research in Medical Sciences (2014)