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Fabrication and Characterization of Novel Diopside/Silk Fibroin Nanocomposite Scaffolds for Potential Application in Maxillofacial Bone Regeneration Publisher Pubmed



Ghorbanian L1, 2 ; Emadi R1 ; Razavi SM2 ; Shin H3 ; Teimouri A4
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran
  2. 2. Torabinejad Dental Research Center and Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Bioengineering, Hanyang University, Seoul 133-791, South Korea
  4. 4. Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2013


Abstract

Novel freeze-dried porous composite scaffolds were prepared from natural polymer of silk fibroin (SF) as a matrix and from diopside nanoceramic as a bioactive reinforcing agent through a freeze-drying method. Considering the superiority of both diopside and SF in terms of mechanical and biochemical properties (in comparison to similar ceramics and polymers, especially in maxillofacial specific applications), we investigated the effect of diopside nanoparticle contents. Microstructure studies illustrated that the bioactive diopside nanoparticles were distributed throughout the fibroin matrix. Enough porosity, desired surface properties, high mechanical strength and excellent in vitro biocompatibility were achieved during the fabrication of the nanocomposite scaffolds without any extra modifications. © 2013 Elsevier B.V.
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