Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Faculty Members have conducted research related to the The Gene Expression Profile and Dna Methylation Pattern of Cdh1 and Dnmt1 Genes in Acute Promyelocytic Leukemia (Apl)
Seyed Hamidollah Ghaffari
Seyed Hamidollah Ghaffari

Professor of Molecular Genetics

Shariati Hospital

Hematology, Oncology and Stem Cell Transplantation Research Center

Tehran University of Medical Sciences

All Documents
1. The Pi3k Signaling Pathway; From Normal Lymphopoiesis to Lymphoid Malignancies, Expert Review of Anticancer Therapy (2024)
2. Minimal Residual Disease Detection Using Gene Scanning Analysis, Fluorescent Fragment Analysis, and Capillary Electrophoresis for Igh Rearrangement in Adult B-Lineage Acute Lymphoblastic Leukemia: A Cross-Sectional Study, Cell Journal (2023)
3. Overexpression of Bromodomain and Extraterminal Domain Is Associated With Progression, Metastasis and Unfavorable Outcomes: Highlighting Prognostic and Therapeutic Value of the Bet Protein Family in Gastric Cancer, Anti-Cancer Agents in Medicinal Chemistry (2023)
4. The Effects of Abemaciclib on Cell Cycle and Apoptosis Regulation in Anaplastic Thyroid Cancer Cells, Molecular Biology Reports (2023)
5. A Comparative Study of the Bone Marrow and Umbilical Cord-Derived Mesenchymal Stem Cells (Mscs) Efficiency on Generating Msc-Educated Macrophages (Mems), Asian Pacific Journal of Cancer Prevention (2022)
6. A Panel of Circulating Micrornas As a Potential Biomarker for the Early Detection of Gastric Cancer, Avicenna Journal of Medical Biotechnology (2022)
7. An Overview of Long Noncoding Rnas: Biology, Functions, Therapeutics, Analysis Methods, and Bioinformatics Tools, Cell Biochemistry and Function (2022)
8. Blockade of Nuclear Factor-Kb (Nf-Kb) Pathway Using Bay 11-7082 Enhances Arsenic Trioxide-Induced Antiproliferative Activity in U87 Glioblastoma Cells, Reports of Biochemistry and Molecular Biology (2022)
9. Dual-Specificity Phosphatases: Therapeutic Targets in Cancer Therapy Resistance, Journal of Cancer Research and Clinical Oncology (2022)
10. Resistance to Immunotherapy in Human Malignancies: Mechanisms, Research Progresses, Challenges, and Opportunities, Journal of Cellular Physiology (2022)
11. Targeting Macrophage-Mediated Tumor Cell Phagocytosis: An Overview of Phagocytosis Checkpoints Blockade, Nanomedicine Intervention, and Engineered Car-Macrophage Therapy, International Immunopharmacology (2022)
12. The Dna Methylation in Neurological Diseases, Cells (2022)
13. The Evaluation of Tlr1, Tlr2, Tlr4, Tlr7, and Tlr8 Expression Levels in the Newly-Diagnosed Acute Myeloid Leukemia (Aml) Patients, Iranian Journal of Blood and Cancer (2022)
14. The Long-Term Outcome and Efficacy of Pr1/Bcr-Abl Multipeptides Vaccination in Chronic Myeloid Leukemia: Results of a 7-Year Longitudinal Investigation, Iranian Journal of Blood and Cancer (2022)
15. Abrogation of Histone Deacetylases (Hdacs) Decreases Survival of Chronic Myeloid Leukemia Cells: New Insight Into Attenuating Effects of the Pi3k/C-Myc Axis on Panobinostat Cytotoxicity, Cell Biology International (2021)
16. Alteration of Ppar-Gamma (Pparg; Pparγ) and Pten Gene Expression in Acute Myeloid Leukemia Patients and the Promising Anticancer Effects of Pparγ Stimulation Using Pioglitazone on Aml Cells, Molecular Genetics and Genomic Medicine (2021)
17. Anti-Proliferative Activity of Disulfiram Through Regulation of the Akt-Foxo Axis: A Proteomic Study of Molecular Targets, Biochimica et Biophysica Acta - Molecular Cell Research (2021)
18. Car T Cell Therapy in Solid Tumors; With an Extensive Focus on Obstacles and Strategies to Overcome the Challenges, International Immunopharmacology (2021)
19. Cediranib, a Pan-Inhibitor of Vascular Endothelial Growth Factor Receptors, Inhibits Proliferation and Enhances Therapeutic Sensitivity in Glioblastoma Cells, Life Sciences (2021)
20. Evaluation of Htert, Krt7, and Survivin in Urine for Noninvasive Detection of Bladder Cancer Using Real‐Time Pcr, BMC Urology (2021)
21. Inhibition of C-Myc Using 10058-F4 Induces Anti-Tumor Effects in Ovarian Cancer Cells Via Regulation of Foxo Target Genes, European Journal of Pharmacology (2021)
22. Investigation of the Osteopontin Isoforms Expression in Patients With Acute Myeloid Leukemia, Medical Oncology (2021)
23. Mesenchymal Stromal/Stem Cells (Mscs) and Msc-Derived Extracellular Vesicles in Covid-19-Induced Ards: Mechanisms of Action, Research Progress, Challenges, and Opportunities, International Immunopharmacology (2021)
24. Recent Advances in Immune Checkpoint Therapy in Non-Small Cell Lung Cancer and Opportunities for Nanoparticle-Based Therapy, European Journal of Pharmacology (2021)
25. Small Molecules With Huge Impacts: The Role of Mirna-Regulated Pi3k Pathway in Human Malignancies, Molecular Biology Reports (2021)
26. The Role of Toll-Like Receptor 4 (Tlr4) in Cancer Progression: A Possible Therapeutic Target?, Journal of Cellular Physiology (2021)
27. Toll-Like Receptor 4 Signaling Pathway Is Correlated With Pathophysiological Characteristics of Aml Patients and Its Inhibition Using Tak-242 Suppresses Aml Cell Proliferation, International Immunopharmacology (2021)
28. Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists, IUBMB Life (2021)
29. Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis, Journal of Cellular and Molecular Medicine (2021)
30. Abemaciclib (Cdk4/6 Inhibitor) Blockade Induces Cytotoxicity in Human Anaplastic Thyroid Carcinoma Cells, Reports of Biochemistry and Molecular Biology (2020)
31. Anti-Tumor Activity of Cediranib, a Pan-Vascular Endothelial Growth Factor Receptor Inhibitor, in Pancreatic Ductal Adenocarcinoma Cells, Cellular Oncology (2020)
32. Arsenic Trioxide and Bibr1532 Synergistically Inhibit Breast Cancer Cell Proliferation Through Attenuation of Nf-Κb Signaling Pathway, Life Sciences (2020)
33. Cediranib, an Inhibitor of Vascular Endothelial Growth Factor Receptor Kinases, Inhibits Proliferation and Invasion of Prostate Adenocarcinoma Cells, European Journal of Pharmacology (2020)
34. Egfr Blockade Reverses Cisplatin Resistance in Human Epithelial Ovarian Cancer Cells, Iranian Biomedical Journal (2020)
35. Investigation of the Correlation Between Androgen Receptor and Zeb1 and Its Value in Progression of Gastric Cancer, Avicenna Journal of Medical Biotechnology (2020)
36. Methylation Analysis of P16, Rassf1a, Rprm, and Runx3 in Circulating Cell-Free Dna for Detection of Gastric Cancer: A Validation Study, Avicenna Journal of Medical Biotechnology (2020)
37. Prognostic and Therapeutic Significance of Androgen Receptor in Patients With Gastric Cancer, OncoTargets and Therapy (2020)
38. Prognostic and Therapeutic Significance of Circulating Tumor Cells in Patients With Lung Cancer, Cellular Oncology (2020)
39. Significant Decrease in the Viability and Tumor Stem Cell Marker Expression in Tumor Cell Lines Treated With Curcumin, Journal of Herbal Medicine (2020)
40. Small Molecule Inhibitor of Tlr4 Inhibits Ovarian Cancer Cell Proliferation: New Insight Into the Anticancer Effect of Tak-242 (Resatorvid), Cancer Chemotherapy and Pharmacology (2020)
41. The Anticancer Effect of the Tlr4 Inhibition Using Tak-242 (Resatorvid) Either As a Single Agent or in Combination With Chemotherapy: A Novel Therapeutic Potential for Breast Cancer, Journal of Cellular Biochemistry (2020)
42. An Overview of Micrornas: Biology, Functions, Therapeutics, and Analysis Methods, Journal of Cellular Physiology (2019)
43. Anti-Tumor Activity of Neratinib, a Pan-Her Inhibitor, in Gastric Adenocarcinoma Cells, European Journal of Pharmacology (2019)
44. Blockade of Tlr4 Using Tak-242 (Resatorvid) Enhances Anti-Cancer Effects of Chemotherapeutic Agents: A Novel Synergistic Approach for Breast and Ovarian Cancers, Immunologic Research (2019)
45. Contributory Role of Micrornas in Anti-Cancer Effects of Small Molecule Inhibitor of Telomerase (Bibr1532) on Acute Promyelocytic Leukemia Cell Line, European Journal of Pharmacology (2019)
46. Evaluation of the Association Between Androgen Receptor and Aurka and Its Prognostic Value in Gastric Cancer, International Journal of Hematology-Oncology and Stem Cell Research (2019)
47. Il-6/Il-6R Pathway Is a Therapeutic Target in Chemoresistant Ovarian Cancer, Tumori (2019)
48. Residual Methylation of Tumor Suppressor Gene Promoters, Rassf6 and Rassf10, As Novel Biomarkers for Minimal Residual Disease Detection in Adult Acute Lymphoblastic Leukemia, Annals of Hematology (2019)
49. The Correlation Between Egfr and Androgen Receptor Pathways: A Novel Potential Prognostic Marker in Gastric Cancer, Anti-Cancer Agents in Medicinal Chemistry (2019)
50. The Erbb Receptor Inhibitor Dacomitinib Suppresses Proliferation and Invasion of Pancreatic Ductal Adenocarcinoma Cells, Cellular Oncology (2019)
51. Tlr4 Blockade Using Tak-242 Suppresses Ovarian and Breast Cancer Cells Invasion Through the Inhibition of Extracellular Matrix Degradation and Epithelial-Mesenchymal Transition, European Journal of Pharmacology (2019)
52. Why Have Microrna Biomarkers Not Been Translated From Bench to Clinic?, Future Oncology (2019)
53. Antileukemic Effects of Neurokinin-1 Receptor Inhibition on Hematologic Malignant Cells: A Novel Therapeutic Potential for Aprepitant, Anti-Cancer Drugs (2018)
54. Arsenic Trioxide Induction Autophagy in Human Acute Promyelocytic Leukemia, Koomesh (2018)
55. Blockade of Jak2/Stat3 Intensifies the Anti-Tumor Activity of Arsenic Trioxide in Acute Myeloid Leukemia Cells: Novel Synergistic Mechanism Via the Mediation of Reactive Oxygen Species, European Journal of Pharmacology (2018)
56. Blockade of Nuclear Factor-Κb (Nf-Κb) Pathway Inhibits Growth and Induces Apoptosis in Chemoresistant Ovarian Carcinoma Cells, International Journal of Biochemistry and Cell Biology (2018)
57. Disulfiram/Copper Causes Ros Levels Alteration, Cell Cycle Inhibition, and Apoptosis in Acute Myeloid Leukaemia Cell Lines With Modulation in the Expression of Related Genes, Biomedicine and Pharmacotherapy (2018)
58. Evaluation of the Gene Expression of the Cytoprotective Proteins in Response to Daunorubicin in U937 Cells, International Journal of Cancer Management (2018)
59. Expression Analysis of Pvt1, Ccdc26, and Ccat1 Long Noncoding Rnas in Acute Myeloid Leukemia Patients, Genetic Testing and Molecular Biomarkers (2018)
60. Inhibition of Bromodomain and Extraterminal Domain Reduces Growth and Invasive Characteristics of Chemoresistant Ovarian Carcinoma Cells, Anti-Cancer Drugs (2018)
61. Low Expression of Long Noncoding Rna Irain Is Associated With Poor Prognosis in Non-M3 Acute Myeloid Leukemia Patients, Genetic Testing and Molecular Biomarkers (2018)
62. Minimal Residual Disease (Mrd) Detection Using Rearrangement of Immunoglobulin/T Cell Receptor Genes in Adult Patients With Acute Lymphoblastic Leukemia (All), Annals of Hematology (2018)
63. Neurokinin-1 Receptor (Nk1r) Inhibition Sensitizes Apl Cells to Anti-Tumor Effect of Arsenic Trioxide Via Restriction of Nf-Κb Axis: Shedding New Light on Resistance to Aprepitant, International Journal of Biochemistry and Cell Biology (2018)
64. Osteopontin B and C Splice Isoforms in Leukemias and Solid Tumors: Angiogenesis Alongside Chemoresistance, Asian Pacific Journal of Cancer Prevention (2018)
65. Overexpression of Endometrial Estrogen Receptor-Alpha in the Window of Implantation in Women With Unexplained Infertility, International Journal of Fertility and Sterility (2018)
66. Parp-1 Overexpression As an Independent Prognostic Factor in Adult Non-M3 Acute Myeloid Leukemia, Genetic Testing and Molecular Biomarkers (2018)
67. Redistribution of Cell Cycle by Arsenic Trioxide Is Associated With Demethylation and Expression Changes of Cell Cycle Related Genes in Acute Promyelocytic Leukemia Cell Line (Nb4), Annals of Hematology (2018)
68. Targeting of Egfr Increase Anti-Cancer Effects of Arsenic Trioxide: Promising Treatment for Glioblastoma Multiform, European Journal of Pharmacology (2018)
69. The Association Between Parp1 and Lig3 Expression Levels and Chromosomal Translocations in Acute Myeloid Leukemia Patients, Cell Journal (2018)
70. The Potential Contribution of Micrornas in Anti-Cancer Effects of Aurora Kinase Inhibitor (Azd1152-Hqpa), Journal of Molecular Neuroscience (2018)
71. A Comparative Cytotoxic Evaluation of Disulfiram Encapsulated Plga Nanoparticles on Mcf-7 Cells, International Journal of Hematology-Oncology and Stem Cell Research (2017)
72. Anti-Cancer Effect of Aprepitant on Nb4 Leukemic Cells, Journal of Babol University of Medical Sciences (2017)
73. Anti-Tumor Activity of Pi3k-Δ Inhibitor in Hematologic Malignant Cells: Shedding New Light on Resistance to Idelalisib, International Journal of Biochemistry and Cell Biology (2017)
74. Anti-Tumour Activity of Tivozanib, a Pan-Inhibitor of Vegf Receptors, in Therapy-Resistant Ovarian Carcinoma Cells, Scientific Reports (2017)
75. Asxl1 and Jak2v617f Gene Mutation Screening in Iranian Patients With Chronic Myeloid Leukemia, Asia-Pacific Journal of Clinical Oncology (2017)
76. Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells, Scientific Reports (2017)
77. Colorectal Cancer Screening: A Comprehensive Review to Recent Non-Invasive Methods, International Journal of Hematology-Oncology and Stem Cell Research (2017)
78. Dacomitinib, a Pan-Inhibitor of Erbb Receptors, Suppresses Growth and Invasive Capacity of Chemoresistant Ovarian Carcinoma Cells, Scientific Reports (2017)
79. Demethylation and Alterations in the Expression Level of the Cell Cycle–Related Genes As Possible Mechanisms in Arsenic Trioxide–Induced Cell Cycle Arrest in Human Breast Cancer Cells, Tumor Biology (2017)
80. Dna Hypermethylation of Tumor Suppressor Genes Rassf6 and Rassf10 As Independent Prognostic Factors in Adult Acute Lymphoblastic Leukemia, Leukemia Research (2017)
81. Endometrial Expression of Β3 Integrin, Calcitonin and Plexin-B1 in the Window of Implantation in Women With Unexplained Infertility, International Journal of Reproductive BioMedicine (2017)
82. Inhibition of Telomerase Using Bibr1532 Enhances Doxorubicin-Induced Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cells, Hematology (2017)
83. Lung Cancer-Associated Brain Metastasis: Molecular Mechanisms and Therapeutic Options, Cellular Oncology (2017)
84. Novel Pan Pi3k Inhibitor-Induced Apoptosis in Apl Cells Correlates With Suppression of Telomerase: An Emerging Mechanism of Action of Bkm120, International Journal of Biochemistry and Cell Biology (2017)
85. Opn B and C Isoforms Doubtless Veto Anti-Angiogenesis Effects of Curcumin in Combination With Conventional Aml Regiment, Asian Pacific Journal of Cancer Prevention (2017)
86. Osteopontin B and C Isoforms: Molecular Candidates Associated With Leukemic Stem Cell Chemoresistance in Acute Myeloid Leukemia, Asian Pacific Journal of Cancer Prevention (2017)
87. Osteopontin Plays a Unique Role in Resistance of Cd34 +/Cd123 + Human Leukemia Cell Lines Kg1a to Parthenolide, Life Sciences (2017)
88. Parthenolide Reduces Gene Transcription of Prosurvival Mediators in U937 Cells, Experimental Oncology (2017)
89. Pharmacological Evidence for the Involvement of Adenosine Triphosphate Sensitive Potassium Channels in Chloroquine-Induced Itch in Mice, Pharmacological Reports (2017)
90. Pi3k-Δ Inhibition Using Cal-101 Exerts Apoptotic Effects and Increases Doxorubicin-Induced Cell Death in Pre-B-Acute Lymphoblastic Leukemia Cells, Anti-Cancer Drugs (2017)
91. Reactive Oxygen Species Generation and Increase in Mitochondrial Copy Number: New Insight Into the Potential Mechanism of Cytotoxicity Induced by Aurora Kinase Inhibitor, Azd1152-Hqpa, Anti-Cancer Drugs (2017)
92. Reciprocal Interactions of Leukemic Cells With Bone Marrow Stromal Cells Promote Enrichment of Leukemic Stell Cell Compartments in Response to Curcumin and Daunorubicin, Asian Pacific Journal of Cancer Prevention (2017)
93. Survivin Isoform Expression in Arsenic Trioxide-Treated Acute Promyelocytic Leukemia Cell Line and Patients: The Odd Expression Pattern of Survivin-2Α, Asia-Pacific Journal of Clinical Oncology (2017)
94. Targeting Human Telomerase Rna Component Using Antisense Oligonucleotide Induces Rapid Cell Death and Increases Ato-Induced Apoptosis in Apl Cells, European Journal of Pharmacology (2017)
95. The Relationship Between Str-Pcr Chimerism Analysis and Chronic Gvhd Following Hematopoietic Stem Cell Transplantation, International Journal of Hematology-Oncology and Stem Cell Research (2017)
96. Acquired Expression of Osteopontin Selectively Promotes Enrichment of Leukemia Stem Cells Through Akt/Mtor/Pten/Β-Catenin Pathways in Aml Cells, Life Sciences (2016)
97. Arsenic Trioxide Alters the Microrna Expression Profile of U87 Glioblastoma, Anti-Cancer Agents in Medicinal Chemistry (2016)
98. Arsenic Trioxide Induces Apoptosis and Incapacitates Proliferation and Invasive Properties of U87mg Glioblastoma Cells Through a Possible Nf-Κb-Mediated Mechanism, Asian Pacific Journal of Cancer Prevention (2016)
99. Arsenic Trioxide Induces Cell Cycle Arrest and Alters Dna Methylation Patterns of Cell Cycle Regulatory Genes in Colorectal Cancer Cells, Life Sciences (2016)
100. Curcumin Veto the Effects of Osteopontin (Opn) Specific Inhibitor on Leukemic Stem Cell Colony Forming Potential Via Promotion of Opn Overexpression, International Journal of Hematology-Oncology and Stem Cell Research (2016)
101. Delivery of Disulfiram Into Breast Cancer Cells Using Folate-Receptor-Targeted Plga-Peg Nanoparticles: In Vitro and in Vivo Investigations, Journal of Nanobiotechnology (2016)
102. Effects of Silibinin on Growth and Invasive Properties of Human Ovarian Carcinoma Cells Through Suppression of Heregulin/Her3 Pathway, Tumor Biology (2016)
103. Erratum To: Expression Pattern of Htert Telomerase Subunit Gene in Different Stages of Chronic Myeloid Leukemia (Mol Biol Rep, 41, (2014), 5557-5561, 10.1007/S11033-014-3472-3), Molecular Biology Reports (2016)
104. Inhibition of Tachykinin Nk1receptor Using Aprepitant Induces Apoptotic Cell Death and G1 Arrest Through Akt/P53 Axis in Pre-B Acute Lymphoblastic Leukemia Cells, European Journal of Pharmacology (2016)
105. Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy Via Dna Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to Azd1152-Hqpa, Molecular Neurobiology (2016)
106. Inhibitor of Pan Class-I Pi3k Induces Differentially Apoptotic Pathways in Acute Leukemia Cells: Shedding New Light on Nvp-Bkm120 Mechanism of Action, International Journal of Biochemistry and Cell Biology (2016)
107. Jak2v617f Allele Burden Measurement in Peripheral Blood of Iranian Patients With Myeloproliferative Neoplasms and Effect of Hydroxyurea on Jak2v617f Allele Burden, International Journal of Hematology-Oncology and Stem Cell Research (2016)
108. Lithium Attenuated the Depressant and Anxiogenic Effect of Juvenile Social Stress Through Mitigating the Negative Impact of Interlukin-1Β and Nitric Oxide on Hypothalamic-Pituitary-Adrenal Axis Function, Neuroscience (2016)
109. Melatonin Promotes Ato-Induced Apoptosis in Mcf-7 Cells: Proposing Novel Therapeutic Potential for Breast Cancer, Biomedicine and Pharmacotherapy (2016)
110. Significance of Azd1152 As a Potential Treatment Against Aurora B Overexpression in Acute Promyelocytic Leukemia, Annals of Hematology (2016)
111. The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes, Materials Science and Engineering C (2016)
112. Tropisetron Suppresses Colitis-Associated Cancer in a Mouse Model in the Remission Stage, International Immunopharmacology (2016)
113. Apigenin Modulates the Expression Levels of Pro-Inflammatory Mediators to Reduce the Human Insulin Amyloid-Induced Oxidant Damages in Sk-N-Mc Cells, Human and Experimental Toxicology (2015)
114. Azd1152-Hqpa Induces Growth Arrest and Apoptosis in Androgen-Dependent Prostate Cancer Cell Line (Lncap) Via Producing Aneugenic Micronuclei and Polyploidy, Tumor Biology (2015)
115. Expression Analysis of Microrna-125 in Patients With Polycythemia Vera and Essential Thrombocythemia and Correlation With Jak2 Allele Burden and Laboratory Findings, International Journal of Laboratory Hematology (2015)
116. Reciprocal Interconnection of Mirnome-Epigenome in Cancer Pathogenesis and Its Therapeutic Potential, Epigenetics Territory and Cancer (2015)
117. Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera, Medical Oncology (2011)
118. Arms-Pcr Versus As-Pcr to Evaluate Jak2v617f Mutation in Patients With Non-Cml Myeloproliferative Neoplasms, Tehran University Medical Journal (2010)
119. Comparisions of Arms-Pcr and As-Pcr for the Evaluation of Jak2v617f Mutation in Patients With Non-Cml Myeloproliferative Neoplasms, International Journal of Hematology-Oncology and Stem Cell Research (2010)
120. Evaluation of Jak2 V617f Mutation and Correlations of This Mutation With Clinical and Laboratory Findings in Patients With Myeloproliferative Neoplasms, Journal of Isfahan Medical School (2010)
121. Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia, International Journal of Hematology-Oncology and Stem Cell Research (2009)