Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Hif-1Α Confers Resistance to Induced Stress in Bone Marrow-Derived Mesenchymal Stem Cells
Ali Jahanian Najafabadi
Ali Jahanian Najafabadi

Professor of Pharmaceutical Biotechnology

Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences

Isfahan University of Medical Sciences

All Documents
1. Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects Against Triple-Negative Breast Cancer Cells, Journal of Inorganic and Organometallic Polymers and Materials (2024)
2. Platelet-Cloaked Alginate-Poly (Β-Amino Ester) a Novel Platform Bioinspired Polyelectrolyte Nanoparticle for Targeted Delivery of Carboplatin in Breast Cancer: An in Vitro/In Vivo Study, International Journal of Pharmaceutics (2024)
3. Recombinant Production of Tp4-Lyc1, a New Chimeric Peptide With Targeted Cytotoxicity to Hela Cells, Avicenna Journal of Medical Biotechnology (2024)
4. Application of Antimicrobial Peptides in the Design and Production of Anticancer Agents, International Journal of Peptide Research and Therapeutics (2023)
5. Human Umbilical Cord-Derived Mesenchymal Stem Cells-Harvested Mitochondrial Transplantation Improved Motor Function in Tbi Models Through Rescuing Neuronal Cells From Apoptosis and Alleviating Astrogliosis and Microglia Activation, International Immunopharmacology (2023)
6. Lipocalin-2 Upregulation in Nasopharyngeal Carcinoma: A Novel Potential Diagnostic Biomarker, Iranian Journal of Medical Sciences (2023)
7. Novel N-Α-Amino Acid Spacer-Conjugated Phthalimide–Triazine Derivatives: Synthesis, Antimicrobial and Molecular Docking Studies, Amino Acids (2023)
8. Combination Therapy of Metadichol Nanogel and Lipocalin-2 Engineered Mesenchymal Stem Cells Improve Wound Healing in Rat Model of Excision Injury, Advanced Pharmaceutical Bulletin (2022)
9. The Effects of Garlic Extract on Il-17A Il-17F and Ifnγ Mrna Expression in Peripheral Blood Mononuclear Cells of Multiple Sclerosis Patients, Journal of Isfahan Medical School (2022)
10. Conditioned Medium Harvested From Hif1α Engineered Mesenchymal Stem Cells Ameliorates Lad-Occlusion -Induced Injury in Rat Acute Myocardial Ischemia Model, International Journal of Biochemistry and Cell Biology (2021)
11. Design and Production of New Chimeric Reteplase With Enhanced Fibrin Affinity: A Theoretical and Experimental Study, Journal of Biomolecular Structure and Dynamics (2021)
12. Expressing of Recombinant Vegfr2-Specific Nanobody in Baculoviruexpression System, Iranian Journal of Biotechnology (2021)
13. Generation of Hbsag Dna Aptamer Using Modified Cell-Based Selex Strategy, Molecular Biology Reports (2021)
14. Production and Evaluation of In-Vitro and In-Vivo Effects of P28-Il24, a Promising Anti-Breast Cancer Fusion Protein, International Journal of Peptide Research and Therapeutics (2021)
15. Pseudomonas Exotoxin-Based Immunotoxins: Over Three Decades of Efforts on Targeting Cancer Cells With the Toxin, Frontiers in Oncology (2021)
16. Sa/G Hydrogel Containing Nrf2-Engineered Hek-293-Derived Cm Improves Wound Healing Efficacy of Wj-Mscs in a Rat Model of Excision Injury, Journal of Tissue Viability (2021)
17. The Cytotoxic and Pro-Apoptotic Effects of Various Extracts of Allium Giganteum on Mcf-7 and Hela Cell Lines, Journal of Isfahan Medical School (2021)
18. Development of Novel Topical Formulation From Fullerene With Antibacterial Activity Against Propionibacterium Acnes, Fullerenes Nanotubes and Carbon Nanostructures (2020)
19. Effect of Tat-Signaling Fusion System Along With Co-Expression of Groel/Es Chaperones on Secretory Expression of Somatropin, Biotechnologia (2020)
20. Evaluation of Cytotoxic and Apoptotic Effects of Dt386-Br2: A Promising Anticancer Fusion Protein, Journal of Reports in Pharmaceutical Sciences (2020)
21. Evaluation of Soluble Expression of Recombinant Granulocyte Macrophage Stimulating Factor (Rgm-Csf) by Three Different E. Coli Strains, Research in Pharmaceutical Sciences (2020)
22. Expression and One Step Intein-Mediated Purification of Biologically Active Human G-Csf in Escherichia Coli, Molecular Biology Reports (2020)
23. Implication and Role of Neutrophil Gelatinase-Associated Lipocalin in Cancer: Lipocalin-2 As a Potential Novel Emerging Comprehensive Therapeutic Target for a Variety of Cancer Types, Molecular Biology Reports (2020)
24. In Silico Design of Two Novel Fusion Proteins, P28-Il-24 and P28-M4, Targeted to Breast Cancer Cells, Research in Pharmaceutical Sciences (2020)
25. Mesenchymal Stem Cells-Derived Mitochondria Transplantation Mitigates I/R-Induced Injury, Abolishes I/R-Induced Apoptosis, and Restores Motor Function in Acute Ischemia Stroke Rat Model, Brain Research Bulletin (2020)
26. Mitochondrial Characteristics Contribute to Proliferation and Migration Potency of Mda-Mb-231 Cancer Cells and Their Response to Cisplatin Treatment, Life Sciences (2020)
27. Mitochondrial Transplantation Ameliorates Ischemia/Reperfusion-Induced Kidney Injury in Rat, Biochimica et Biophysica Acta - Molecular Basis of Disease (2020)
28. Optimization of Anti-Cxcl10 Nanobody Expression Using Response Surface Methodology and Evaluation of Its Anti-Metastatic Effect on Breast Cancer Cells, International Journal of Peptide Research and Therapeutics (2020)
29. Optimization of Buffer Additives for Efficient Recovery of Hgm-Csf From Inclusion Bodies Using Response Surface Methodology, Iranian Journal of Pharmaceutical Research (2020)
30. Optimization of Solvent Media to Solubilize Tev Protease Using Response Surface Method, Research in Pharmaceutical Sciences (2020)
31. Rgd Peptide Grafted Polybutylene Adipate-Co-Terephthalate/Gelatin Electrospun Nanofibers Loaded With a Matrix Metalloproteinase Inhibitor Drug for Alleviating of Wounds: An In Vitro/In Vivo Study, Drug Development and Industrial Pharmacy (2020)
32. Transfer of Healthy Fibroblast-Derived Mitochondria to Hela Ρ0 and Sas Ρ0 Cells Recovers the Proliferation Capabilities of These Cancer Cells Under Conventional Culture Medium, But Increase Their Sensitivity to Cisplatin-Induced Apoptotic Death, Molecular Biology Reports (2020)
33. Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells Overexpressing Lipocalin 2 Ameliorates Ischemia-Induced Injury and Reduces Apoptotic Death in a Rat Acute Myocardial Infarction Model, Stem Cell Reviews and Reports (2020)
34. A Bi-Functional Targeted P28-Nrc Chimeric Protein With Enhanced Cytotoxic Effects on Breast Cancer Cell Lines, Iranian Journal of Pharmaceutical Research (2019)
35. Chronic Oral Arsenic Exposure and Its Correlation With Serum S100b Concentration, Biological Trace Element Research (2019)
36. Cloning, Optimization of Periplasmic Expression and Purification of Recombinant Granulocyte Macrophage-Stimulating Factor in Escherichia Coli Bl21 (De3), Advanced Biomedical Research (2019)
37. Enhanced Solubility, Oral Bioavailability and Anti-Osteoporotic Effects of Raloxifene Hcl in Ovariectomized Rats by Igepal Co-890 Nanomicelles, Pharmaceutical Development and Technology (2019)
38. Expression, Purification, and Cytotoxic Evaluation of Il24-Br2 Fusion Protein, Research in Pharmaceutical Sciences (2019)
39. Generation and Characterization of a Functional Nanobody Against Inflammatory Chemokine Cxcl10, As a Novel Strategy for the Treatment of Multiple Sclerosis, CNS and Neurological Disorders - Drug Targets (2019)
40. Her-2 Aptamer-Targeted Ecoflex® Nanoparticles Loaded With Docetaxel Promote Breast Cancer Cells Apoptosis and Anti-Metastatic Effect, IET Nanobiotechnology (2019)
41. High-Yield Production of Granulocyte-Macrophage Colony-Stimulating Factor in E. Coli Bl21 (De3) by an Auto-Induction Strategy, Iranian Journal of Pharmaceutical Research (2019)
42. Implementation of Electrochemical Impedance Spectroscopy to Evaluate Her-2 Aptamer Conjugation to Ecoflex® Nanoparticles for Docetaxel Delivery in Breast Cancer Cells, Journal of Applied Electrochemistry (2019)
43. Improvement of Solubility and Yield of Recombinant Protein Expression in E. Coli Using a Two-Step System, Research in Pharmaceutical Sciences (2019)
44. Improvement of Soluble Expression of Gm-Csf in the Cytoplasm of Escherichia Coli Using Chemical and Molecular Chaperones, Protein Expression and Purification (2019)
45. Klotho Induces Insulin Resistance Possibly Through Interference With Glut4 Translocation and Activation of Akt, Gsk3β, and Pfkfβ3 in 3T3-L1 Adipocyte Cells, Research in Pharmaceutical Sciences (2019)
46. Novel Palladium Complex: Cytotoxicity Against Cisplatin-Resistant K562 Cells, Iranian Journal of Pharmaceutical Research (2019)
47. Pegylated Trimethylchitosan Emulsomes Conjugated to Octreotide for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma Cells of Hepg2, Journal of Liposome Research (2019)
48. Production of Novel Camelid Anti-Cxcl10 Specific Polyclonal Antibodies and Evaluation of Their Bioreactivity, International Journal of Peptide Research and Therapeutics (2019)
49. Reteplase: Structure, Function, and Production, Advanced Biomedical Research (2019)
50. Targeted Diphtheria Toxin-Based Therapy: A Review Article, Frontiers in Microbiology (2019)
51. Trastuzumab-Conjugated Nanoparticles Composed of Poly(Butylene Adipate-Co-Butylene Terephthalate) Prepared by Electrospraying Technique for Targeted Delivery of Docetaxel, IET Nanobiotechnology (2019)
52. A Novel Mixed Polymeric Micelle for Co-Delivery of Paclitaxel and Retinoic Acid and Overcoming Multidrug Resistance: Synthesis, Characterization, Cytotoxicity, and Pharmacokinetic Evaluation, Drug Development and Industrial Pharmacy (2018)
53. A-Ngr Fusion Protein Induces Apoptosis in Human Cancer Cells, EXCLI Journal (2018)
54. Association of Aire Polymorphism and the Susceptibility to Multiple Sclerosis in Iranian Population, Avicenna Journal of Medical Biotechnology (2018)
55. Cloning, Expression, and Assessment of Cytotoxic Effects of A-Ngr Fusion Protein, International Journal of Peptide Research and Therapeutics (2018)
56. Efavirenz Oral Delivery Via Lipid Nanocapsules: Formulation, Optimisation, and Ex-Vivo Gut Permeation Study, IET Nanobiotechnology (2018)
57. Formulation and Characterization of Cellulose Acetate Butyrate Nanoparticles Loaded With Nevirapine for Hiv Treatment, Journal of Drug Delivery Science and Technology (2018)
58. Introduction of a Novel Cancer Cell Targeted Fusion Protein: Dt386-Br2, Annals of Oncology (2018)
59. Lipocalin 2 Enhances Mesenchymal Stem Cell-Based Cell Therapy in Acute Kidney Injury Rat Model, Cytotechnology (2018)
60. Lipocalin2 Protects Human Embryonic Kidney Cells Against Cisplatin– Induced Genotoxicity, Iranian Journal of Pharmaceutical Research (2018)
61. Pharmacokinetics and in Vitro/In Vivo Antitumor Efficacy of Aptamer-Targeted Ecoflex® Nanoparticles for Docetaxel Delivery in Ovarian Cancer, International Journal of Nanomedicine (2018)
62. Poly (Butylene Adipate-Co-Butylene Terephthalate) Nanoparticles Prepared by Electrospraying Technique for Docetaxel Delivery in Ovarian Cancer Induced Mice, Drug Development and Industrial Pharmacy (2018)
63. Poly (Butylene Adipate-Co-Terephthalate) Electrospun Nanofibers Loaded With 5-Fluorouracil and Curcumin in Treatment of Colorectal Cancer Cells, Polymer Testing (2018)
64. Preparation and Characterization of Spray-Dried Inhalable Powders Containing Polymeric Micelles for Pulmonary Delivery of Paclitaxel in Lung Cancer, Journal of Pharmacy and Pharmaceutical Sciences (2018)
65. Synthesis and Characterization of Some Novel Diaryl Urea Derivatives Bearing Quinoxalindione Moiety, Research in Pharmaceutical Sciences (2018)
66. Therapeutic Targeting of Chemokines and Chemokine Receptors in Multiple Sclerosis: Opportunities and Challenges, CNS and Neurological Disorders - Drug Targets (2018)
67. Biological Evaluation, Docking and Molecular Dynamic Simulation of Some Novel Diaryl Urea Derivatives Bearing Quinoxalindione Moiety, Research in Pharmaceutical Sciences (2017)
68. Biologically Active Heterocyclic Hybrids Based on Quinazolinone, Benzofuran and Imidazolium Moieties: Synthesis, Characterization, Cytotoxic and Antibacterial Evaluation, Chemistry and Biodiversity (2017)
69. Docking Study, Synthesis and Antimicrobial Evaluation of Some Novel 4-Anilinoquinazoline Derivatives, Research in Pharmaceutical Sciences (2017)
70. Evaluation of Cytotoxic Effects of a Dinuclearpalladacycle Derivative, Biphosphinic Complex, on Cisplatin-Resistant Ht-29 Cells, Journal of Reports in Pharmaceutical Sciences (2017)
71. In-Vivo Evaluation of Dt386-Br2, a Promising Anticancer Fusion Protein, in Mice Model, Journal of Isfahan Medical School (2017)
72. Montelukast Incorporated Poly(Methyl Vinyl Ether-Co-Maleic Acid)/Poly(Lactic-Co-Glycolic Acid) Electrospun Nanofibers for Wound Dressing, Fibers and Polymers (2017)
73. Recombinant Production and Intein-Mediated Purification of an Antimicrobial Peptide, Br2, International Journal of Peptide Research and Therapeutics (2017)
74. Synthesis and Antimicrobial Evaluation of Some 2,5 Disubstituted 1,3,4-Oxadiazole Derivatives, Research in Pharmaceutical Sciences (2017)
75. Synthesis and Evaluation of Antimicrobial Activity of Cyclic Imides Derived From Phthalic and Succinic Anhydrides, Research in Pharmaceutical Sciences (2017)
76. Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Some Novel Hybrids Based on Quinazolinone, Benzofuran and Imidazolium Moieties As Potential Cytotoxic and Antimicrobial Agents, Iranian Journal of Basic Medical Sciences (2017)
77. Transferrin-Targeted Poly(Butylene Adipate)/Terephthalate Nanoparticles for Targeted Delivery of 5-Fluorouracil in Ht29 Colorectal Cancer Cell Line, Journal of Bioactive and Compatible Polymers (2017)
78. A Model to Study the Phenotypic Changes of Insect Cell Transfection by Copepod Super Green Fluorescent Protein (Cop-Gfp) in Baculovirus Expression System, Iranian Biomedical Journal (2016)
79. Anti-Pseudomonas Activity of Essential Oil, Total Extract, and Proanthocyanidins of Pinus Eldarica Medw. Bark, Research in Pharmaceutical Sciences (2016)
80. Artificial Blood Substitutes: First Steps on the Long Route to Clinical Utility, Clinical Medicine Insights: Blood Disorders (2016)
81. Exposition of Hepatitis B Surface Antigen (Hbsag) on the Surface of Hek293t Cell and Evaluation of Its Expression, Research in Pharmaceutical Sciences (2016)
82. Expression and Purification of Truncated Diphtheria Toxin, Dt386, in Escherichia Coli: An Attempt for Production of a New Vaccine Against Diphtheria, Research in Pharmaceutical Sciences (2016)
83. Luteinizing Hormone-Releasing Hormone Targeted Poly(Methyl Vinyl Ether Maleic Acid) Nanoparticles for Doxorubicin Delivery to Mcf-7 Breast Cancer Cells, IET Nanobiotechnology (2016)
84. Production and Evaluation of Cytotoxic Effects of Dt386-Br2 Fusion Protein As a Novel Anti-Cancer Agent, Journal of Microbiological Methods (2016)
85. Recombinant Expression and Purification of Functional Vascular Endothelial Growth Factor-121 in the Baculovirus Expression System, Asian Pacific Journal of Tropical Medicine (2016)
86. Targeted Delivery of Docetaxel by Use of Transferrin/Poly(Allylamine Hydrochloride)-Functionalized Graphene Oxide Nanocarrier, ACS Applied Materials and Interfaces (2016)
87. The Effect of Intrathecal Administration of the Neuronal N-Type Calcium Channels Antagonist, Ω-Conotoxin Mviia, on Attenuating the Spontaneous and Naloxone-Precipitated Morphine Withdrawal in Rats, Toxin Reviews (2016)
88. Theoretical Design of a New Chimeric Protein for the Treatment of Breast Cancer, Research in Pharmaceutical Sciences (2016)
89. Adenovirus-Mediated Over-Expression of Nrf2 Within Mesenchymal Stem Cells (Mscs) Protected Rats Against Acute Kidney Injury, Advanced Pharmaceutical Bulletin (2015)
90. Co-Culture of Bone Marrow-Derived Mesenchymal Stem Cells Overexpressing Lipocalin 2 With Hk-2 and Hek293 Cells Protects the Kidney Cells Against Cisplatin-Induced Injury, Cell Biology International (2015)
91. In Silico Design, Cloning and High Level Expression of L7/L12-Tomp31 Fusion Protein of Brucella Antigens, Research in Pharmaceutical Sciences (2015)
92. In Vitro Augmentation of Mesenchymal Stem Cells Viability in Stressful Microenvironments: In Vitro Augmentation of Mesenchymal Stem Cells Viability, Cell Stress and Chaperones (2015)
93. Molecualr Cloning of the Capsular Antigen F1 of Yersinia Pestis in Pbad/Giii Plasmid, Research in Pharmaceutical Sciences (2015)
94. Antigenicity and Immunogenicity of Fused B-Subunit of Heat Labile Toxin of Escherichia Coli and Colonization Factor Antigen I Polyepitopes, Journal of Microbiological Methods (2014)
95. In Silico and in Vivo Studies of Truncated Forms of Flagellin (Flic) of Enteroaggregative Escherichia Coli Fused to Fimh From Uropathogenic Escherichia Coli As a Vaccine Candidate Against Urinary Tract Infections, Journal of Biotechnology (2014)
96. Recombinant Human Lipocalin 2 Acts As an Antibacterial Agent to Prevent Platelet Contamination, Hematology (2014)
97. Expression of the Recombinant Plasminogen Activator (Reteplase) by a Non-Lytic Insect Cell Expression System, Research in Pharmaceutical Sciences (2013)
98. Hif-1Α Confers Resistance to Induced Stress in Bone Marrow-Derived Mesenchymal Stem Cells, Archives of Medical Research (2013)
99. In Silico and in Vitro Studies of Truncated Forms of Flagellin (Flic) of Enteroaggregative Escherichia Coli (Eaec), Molecular Informatics (2013)
100. Lipocalin-2-Mediated Upregulation of Various Antioxidants and Growth Factors Protects Bone Marrow-Derived Mesenchymal Stem Cells Against Unfavorable Microenvironments, Cell Stress and Chaperones (2013)
101. Optimization of the Expression of Genes Encoding Poly (3-Hydroxyalkanoate) Synthase From Pseudomonas Aeruginosa Ptcc 1310 in Escherichia Coli, Avicenna Journal of Medical Biotechnology (2012)
102. Identification of an Isolate of Pseudomonas Aeroginosa Deposited in Ptcc As a Pha Producer Strain: Comparison of Three Different Bacterial Genomic Dna Extraction Methods, Journal of Biological Sciences (2008)
103. Cloning and Partial Sequencing of Phac1 and Phac2 Genes Encoding Poly (3-Hydroxyalkanoate) Synthases From Pseudomonas Aeroginusa Ptcc 1310, Biotechnology (2007)