Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles

Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles Publisher

Doraghi F¹ ; Edareh MH² ; Ghanbarlou M¹ ; Larijani B¹ ; Mahdavi M¹

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1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Source: Organic and Biomolecular Chemistry Published:2025

Abstract

Benzothiazoles are among the most important heterocycles in pharmaceuticals, natural products, and functional materials. Hence, developing direct and sustainable routes by replacing hazardous/toxic thiol reagents with nontoxic reagents for constructing 2-substituted benzothiazoles is of utmost importance. In this review, we have highlighted many synthetic methods for the synthesis of 2-substituted benzothiazoles from different starting materials under transition metal catalysis or metal-free systems. © 2025 The Royal Society of Chemistry.

Style	Citing Format
MLA	Doraghi F, et al.. "Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles." Organic and Biomolecular Chemistry, vol. 23, no. 21, 2025, pp. 5046-5063.
APA	Doraghi F, Edareh MH, Ghanbarlou M, Larijani B, Mahdavi M (2025). Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles. Organic and Biomolecular Chemistry, 23(21), 5046-5063.
Chicago	Doraghi F, Edareh MH, Ghanbarlou M, Larijani B, Mahdavi M. "Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles." Organic and Biomolecular Chemistry 23, no. 21 (2025): 5046-5063.
Harvard	Doraghi F et al. (2025) 'Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles', Organic and Biomolecular Chemistry, 23(21), pp. 5046-5063.
Vancouver	Doraghi F, Edareh MH, Ghanbarlou M, Larijani B, Mahdavi M. Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles. Organic and Biomolecular Chemistry. 2025;23(21):5046-5063.
BibTex	@article{ author = {Doraghi F and Edareh MH and Ghanbarlou M and Larijani B and Mahdavi M}, title = {Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles}, journal = {Organic and Biomolecular Chemistry}, volume = {23}, number = {21}, pages = {5046-5063}, year = {2025} }
RIS	TY - JOUR AU - Doraghi F AU - Edareh MH AU - Ghanbarlou M AU - Larijani B AU - Mahdavi M TI - Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles JO - Organic and Biomolecular Chemistry VL - 23 IS - 21 SP - 5046 EP - 5063 PY - 2025 ER -

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