Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures

Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures Publisher

Rezaei H^{1, 2} ; Jouyban A^{1, 3} ; Barzegarjalali M⁵ ; Rahimpour E^{1, 6}

Show Affiliations

1. Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2. Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Chemistry, University of North Texas, Denton, 76203-5070, TX, United States
5. Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
6. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Journal of Molecular Liquids Published:2020

Abstract

The solubility profile of codeine phosphate is investigated in the mixture of N-methyl-2-pyrrolidone (NMP) and 2-propanol at various temperatures utilizing a commonly-used shake flask method and the measured data are fitted to some cosolvency models. The density values of codeine phosphate saturated mixtures as another physico-chemical property are measured and represented as a mathematical model. To investigate the model accuracy, the mean relative deviations (MRD %) of the back-calculated density and solubility data are computed. The apparent thermodynamic parameters (i.e. ∆H°, ∆S°, and ∆G°) of the dissolution of codeine phosphate in the binary mixture of NMP and 2-propanal are computed using the Gibbs and van't Hoff equations at Thm. © 2020

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Alireza Foroumadi (1)

Style	Citing Format
MLA	Rezaei H, et al.. "Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures." Journal of Molecular Liquids, vol. 316, no. , 2020, pp. -.
APA	Rezaei H, Jouyban A, Barzegarjalali M, Rahimpour E (2020). Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures. Journal of Molecular Liquids, 316(), -.
Chicago	Rezaei H, Jouyban A, Barzegarjalali M, Rahimpour E. "Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures." Journal of Molecular Liquids 316, no. (2020): -.
Harvard	Rezaei H et al. (2020) 'Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures', Journal of Molecular Liquids, 316(), pp. -.
Vancouver	Rezaei H, Jouyban A, Barzegarjalali M, Rahimpour E. Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures. Journal of Molecular Liquids. 2020;316():-.
BibTex	@article{ author = {Rezaei H and Jouyban A and Barzegarjalali M and Rahimpour E}, title = {Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures}, journal = {Journal of Molecular Liquids}, volume = {316}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Rezaei H AU - Jouyban A AU - Barzegarjalali M AU - Rahimpour E TI - Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures JO - Journal of Molecular Liquids VL - 316 IS - SP - EP - PY - 2020 ER -

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