Iodine-Mediated Synthesis of Novel Pyrazole Derivatives

Iodine-Mediated Synthesis of Novel Pyrazole Derivatives Publisher

Mahdavi M¹ ; Khoshbakht M² ; Saeedi M^{3, 4} ; Asadi M¹ ; Bayat M² ; Foroumadi A¹ ; Shafiee A¹

Show Affiliations

1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Chemistry, Imam Khomeini International University, Qazvin, Iran
3. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Synthesis (Germany) Published:2016

Abstract

The reaction between N,2-diarylhydrazinecarbothioamide (generated from arylhydrazines and aryl isothiocyanates) and malononitrile in the presence of iodine/triethylamine in N,N-dimethylformamide at 80 °C afforded novel pyrazoles, 5-amino-1-aryl-3-(arylamino)-1H-pyrazole-4-carbonitriles, in good yields. In this strategy, iodine served as a versatile desulfurizing agent, efficiently promoting the cyclization reaction. © 2016 Georg Thieme Verlag Stuttgart · New York.

Style	Citing Format
MLA	Mahdavi M, et al.. "Iodine-Mediated Synthesis of Novel Pyrazole Derivatives." Synthesis (Germany), vol. 48, no. 4, 2016, pp. 541-546.
APA	Mahdavi M, Khoshbakht M, Saeedi M, Asadi M, Bayat M, Foroumadi A, Shafiee A (2016). Iodine-Mediated Synthesis of Novel Pyrazole Derivatives. Synthesis (Germany), 48(4), 541-546.
Chicago	Mahdavi M, Khoshbakht M, Saeedi M, Asadi M, Bayat M, Foroumadi A, Shafiee A. "Iodine-Mediated Synthesis of Novel Pyrazole Derivatives." Synthesis (Germany) 48, no. 4 (2016): 541-546.
Harvard	Mahdavi M et al. (2016) 'Iodine-Mediated Synthesis of Novel Pyrazole Derivatives', Synthesis (Germany), 48(4), pp. 541-546.
Vancouver	Mahdavi M, Khoshbakht M, Saeedi M, Asadi M, Bayat M, Foroumadi A, et al.. Iodine-Mediated Synthesis of Novel Pyrazole Derivatives. Synthesis (Germany). 2016;48(4):541-546.
BibTex	@article{ author = {Mahdavi M and Khoshbakht M and Saeedi M and Asadi M and Bayat M and Foroumadi A and Shafiee A}, title = {Iodine-Mediated Synthesis of Novel Pyrazole Derivatives}, journal = {Synthesis (Germany)}, volume = {48}, number = {4}, pages = {541-546}, year = {2016} }
RIS	TY - JOUR AU - Mahdavi M AU - Khoshbakht M AU - Saeedi M AU - Asadi M AU - Bayat M AU - Foroumadi A AU - Shafiee A TI - Iodine-Mediated Synthesis of Novel Pyrazole Derivatives JO - Synthesis (Germany) VL - 48 IS - 4 SP - 541 EP - 546 PY - 2016 ER -

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