Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Iodine-Mediated Synthesis of Novel Pyrazole Derivatives Publisher



Mahdavi M1 ; Khoshbakht M2 ; Saeedi M3, 4 ; Asadi M1 ; Bayat M2 ; Foroumadi A1 ; Shafiee A1
Authors

Source: Synthesis (Germany) Published:2016


Abstract

The reaction between N,2-diarylhydrazinecarbothioamide (generated from arylhydrazines and aryl isothiocyanates) and malononitrile in the presence of iodine/triethylamine in N,N-dimethylformamide at 80 °C afforded novel pyrazoles, 5-amino-1-aryl-3-(arylamino)-1H-pyrazole-4-carbonitriles, in good yields. In this strategy, iodine served as a versatile desulfurizing agent, efficiently promoting the cyclization reaction. © 2016 Georg Thieme Verlag Stuttgart · New York.
Related Docs
View other Related Docs
1. Synthesis, Characterization and Biological Evaluation of Novel 3-Methyl-5-Pyrazolone Derivatives, Journal of Medicinal and Chemical Sciences (2021)
2. Design and Synthesis of Novel Nitrothiazolacetamide Conjugated to Different Thioquinazolinone Derivatives As Anti-Urease Agents, Scientific Reports (2022)
3. An Efficient Synthesis of Benzimidazole-Pyrazines Via the Sequential Ugi/Hydroamination/Cyclization Reactions, ChemistrySelect (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (10)
Bagher Larijani (5)
Other Related Docs
4. Synthesis, Reaction and Biological Activity of Pyrazolo[5,1-C][1,2,4]Benzotriazine 5-Oxides, Politics and Religion Journal (2018)
5. Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides, Helvetica Chimica Acta (2016)
6. One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions, Helvetica Chimica Acta (2015)
7. Developments in Organocatalysis Transformations of Unsaturated Pyrazolones, Current Organic Synthesis (2025)
8. An Efficient and Green Synthesis of New 6-Iodo- Pyrano[2,3-D] Pyrimidine-4-Ones Via a One-Pot Four-Component Reaction Followed by Iodocyclization in Water, Polycyclic Aromatic Compounds (2023)
9. Transition Metal-Catalyzed Cross-Coupling Reactions of N-Aryl-2-Aminopyridines, RSC Advances (2025)
10. Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors, Journal of Heterocyclic Chemistry (2017)
11. A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines, Tetrahedron Letters (2019)
12. Recent Advances in Design and Development of Diazole and Diazine Based Fungicides (2014-2023), Journal of Agricultural and Food Chemistry (2024)
13. Vinylazides: Versatile Synthons and Magical Precursors for the Construction of N-Heterocycles, Molecular Diversity (2021)
14. A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines, Journal of Heterocyclic Chemistry (2020)
15. Furo, Pyrano, and Pyrido[2,3-D]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications, ChemistrySelect (2024)
16. Facile, Novel and Efficient Synthesis of New Pyrazolo[3,4-B]Pyridine Products From Condensation of Pyrazole-5-Amine Derivatives and Activated Carbonyl Groups, RSC Advances (2015)