Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery

Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery Publisher Pubmed

Ayati A¹ ; Emami S² ; Asadipour A³ ; Shafiee A¹ ; Foroumadi A^{1, 3}

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1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Chemistry, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medicinal Sciences, Kerman, Iran

Source: European Journal of Medicinal Chemistry Published:2015

Abstract

1,3-Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design and discovery. It is widely found in diverse pharmacologically active substances and in some naturally-occurring compounds. Thiazole is a versatile building-block for lead generation, and is easily access of diverse derivatives for subsequent lead optimization. In the recent years, many thiazole derivatives have been synthesized and subjected to varied biological activities. In this article we intended to review the most important biological effects of thiazole-based compounds and highlight their roles in new leads identification and drug discovery. This article is also intended to help researches for finding potential future directions on the development of more potent and specific analogs of thiazole-based compounds for various biological targets. © 2015 Elsevier Masson SAS.

Style	Citing Format
MLA	Ayati A, et al.. "Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery." European Journal of Medicinal Chemistry, vol. 97, no. 1, 2015, pp. 699-718.
APA	Ayati A, Emami S, Asadipour A, Shafiee A, Foroumadi A (2015). Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery. European Journal of Medicinal Chemistry, 97(1), 699-718.
Chicago	Ayati A, Emami S, Asadipour A, Shafiee A, Foroumadi A. "Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery." European Journal of Medicinal Chemistry 97, no. 1 (2015): 699-718.
Harvard	Ayati A et al. (2015) 'Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery', European Journal of Medicinal Chemistry, 97(1), pp. 699-718.
Vancouver	Ayati A, Emami S, Asadipour A, Shafiee A, Foroumadi A. Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery. European Journal of Medicinal Chemistry. 2015;97(1):699-718.
BibTex	@article{ author = {Ayati A and Emami S and Asadipour A and Shafiee A and Foroumadi A}, title = {Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery}, journal = {European Journal of Medicinal Chemistry}, volume = {97}, number = {1}, pages = {699-718}, year = {2015} }
RIS	TY - JOUR AU - Ayati A AU - Emami S AU - Asadipour A AU - Shafiee A AU - Foroumadi A TI - Recent Applications of 1,3-Thiazole Core Structure in the Identification of New Lead Compounds and Drug Discovery JO - European Journal of Medicinal Chemistry VL - 97 IS - 1 SP - 699 EP - 718 PY - 2015 ER -

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