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Systematic Review and Meta-Analysis on the Prevalence and Antibiotic Susceptibility Pattern in Pseudomonas Aeruginosa Isolated From Cystic Fibrosis Patients Publisher



Rastegarkashkouli A1 ; Khaledi A2 ; Moammer F3 ; Ghenaatpisheh Sanani M4 ; Heidari MM5 ; Foroughi Eghbal A6
Authors
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Authors Affiliations
  1. 1. Isfahan University of Medical Sciences School of Medicine, Isfahan, Iran
  2. 2. Infectious Diseases Reaserch Center, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Student Research Committee, Guilan University of Medical Sciences School of Medicine, Guilan, Iran
  4. 4. Kowsar Hospital Research Committee, Fars Heart Foundation, Shiraz, Iran
  5. 5. Department of Pediatrics, Kashan University of Medical Sciences Faculty of Medicine, Kashan, Iran
  6. 6. Urmia University of Medical Sciences School of Medicine, Urmia, Iran

Source: Eurasian Journal of Medicine Published:2024


Abstract

This study aimed to conduct a retrospective Middle East systematic review and meta-analysis on the prevalence and antibiotic susceptibility pattern for this microorganism isolated from cystic fibrosis patients. We searched MEDLINE, the Cochrane Library, SCOPUS, and Web of Science (ISI) to identify studies that reported the prevalence of Pseudomonas aeruginosa isolated from cystic fibrosis (CF) patients, and antibiotic resistance patterns. To assess the quality of publications was used of a checklist provided by the Joanna Briggs Institute. Finally, the data was analyzed by comprehensive meta-analysis software. The studied populations comprised children and young, and adult CF patients. Patients were aged between 3 months-65 years. A higher percentage of CF patients were males. Pseudomonas aeruginosa frequency varied between 5.9 and 76.2% in the studies included. The combined prevalence of P. aeruginosa was reported 34.3%. The lowest level resistance of P. aeruginosa was toward colistin (0%-13.3%) and ticarcillin (3.9%-24%). Our study showed the prevalence of P. aeruginosa and antibiotic resistance are almost high, while colistin and ticarcillin are the best antibiotics to decrease postantibiotic effects (PAEs) in CF patients from the Middle East. Therefore, physicians should pay more attention to therapeutic protocols to prevent further resistance. © 2024, AVES. All rights reserved.
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