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Retro Mta and Tricalcium Phosphate/Retro Mta for Guided Tissue Regeneration of Periodontal Dehiscence Defects in a Dog Model: A Pilot Study Publisher



Fakheran O1 ; Birang R1 ; Schmidlin PR2 ; Razavi SM3 ; Behfarnia P1
Authors
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Authors Affiliations
  1. 1. Department of Periodontics, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Clinic of Conservative and Preventive Dentistry, Centre of Dental and Oral Medicine, University of Zurich, Plattenstrasse 11, Zurich, 8032, Switzerland
  3. 3. Dental Implant Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Biomaterials Research Published:2019


Abstract

Objectives: Retro MTA is a fast setting Calcium silicate cement used in endodontic regeneration procedures in recent years. Beta-tricalcium phosphate (β-TCP) is another common biomaterial used for bone augmentation procedures. The present pilot study was undertaken to evaluate and compare the efficacy of Retro MTA and a mixture of Retro MTA / β-TCP for periodontal tissue regeneration. Materials and methods: In 4 beagle dogs, periodontal dehiscence type defects were created. In each side, one dehiscence defect was left empty as a control site and three treatment modalities were randomly applied for the others: Retro MTA covered with a collagen membrane, Retro MTA + β-TCP covered with a membrane and covering the defect with a membrane without any bone augmentation. After 8 weeks Animals were sacrificed and Histomorphometric and histologic analysis were conducted. Results: Histologic analysis showed more cementum formation for both Retro MTA+ β-TCP (3.74 ± 0.34 mm) and Retro MTA group (3.24 ± 0.56 mm) compared to control group 1 (1. 15 ± 0.45 mm) and control group 2 (0.78 ± 0.65 mm). Formation of newly formed bone and cementum in the experimental groups were significantly higher as compared to the control groups (P < 0.0001). Conclusions: Retro MTA or Retro MTA+ β-TCP covered with a collagen membrane resulted in regeneration of periodontal tissues. However, Retro MTA+ β-TCP showed tendency towards better results than the use of Retro MTA alone. © 2019 The Author(s).
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