Expression Analysis of Four Long Noncoding Rnas in Breast Cancer

Expression Analysis of Four Long Noncoding Rnas in Breast Cancer Publisher Pubmed

Iranpour M¹ ; Soudyab M¹ ; Geranpayeh L² ; Mirfakhraie R¹ ; Azargashb E³ ; Movafagh A¹ ; Ghafourifard S¹

Show Affiliations

1. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Social Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Tumor Biology Published:2016

Abstract

Breast cancer is a molecularly heterogeneous disease which necessitates a search for markers to provide a more specific classification of this disorder. Long noncoding RNAs as the important subset of noncoding transcripts have been shown to be involved in tumorigenic processes. So, they may be used as markers for early detection of cancer and evaluation of cancer prognosis. In addition, they can be applied as therapeutic targets. In this study, we analyzed expression of four long noncoding RNAs (lncRNAs) namely SOX2OT, PTPRG-AS1, ANRASSF1, and ANRIL in 38 breast cancer tissues and their adjacent noncancerous tissues (ANCTs). ANRASSF1 expression was not detected in any noncancerous tissue. All lncRNAs showed significant overexpression in tumor tissues compared with ANCTs. No association was found between gene expressions and individual clinical data such as tumor stage, grade, size and hormone receptor status except for ANRASSF1 expression and Her2/neu status. In addition, ANRASSF1 and ANRIL expressions were significantly higher in triple negative samples. This study suggests a putative role for these lncRNAs in breast cancer and implies that they can be used as potential cancer biomarkers. © 2015, International Society of Oncology and BioMarkers (ISOBM).

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Style	Citing Format
MLA	Iranpour M, et al.. "Expression Analysis of Four Long Noncoding Rnas in Breast Cancer." Tumor Biology, vol. 37, no. 3, 2016, pp. 2933-2940.
APA	Iranpour M, Soudyab M, Geranpayeh L, Mirfakhraie R, Azargashb E, Movafagh A, Ghafourifard S (2016). Expression Analysis of Four Long Noncoding Rnas in Breast Cancer. Tumor Biology, 37(3), 2933-2940.
Chicago	Iranpour M, Soudyab M, Geranpayeh L, Mirfakhraie R, Azargashb E, Movafagh A, Ghafourifard S. "Expression Analysis of Four Long Noncoding Rnas in Breast Cancer." Tumor Biology 37, no. 3 (2016): 2933-2940.
Harvard	Iranpour M et al. (2016) 'Expression Analysis of Four Long Noncoding Rnas in Breast Cancer', Tumor Biology, 37(3), pp. 2933-2940.
Vancouver	Iranpour M, Soudyab M, Geranpayeh L, Mirfakhraie R, Azargashb E, Movafagh A, et al.. Expression Analysis of Four Long Noncoding Rnas in Breast Cancer. Tumor Biology. 2016;37(3):2933-2940.
BibTex	@article{ author = {Iranpour M and Soudyab M and Geranpayeh L and Mirfakhraie R and Azargashb E and Movafagh A and Ghafourifard S}, title = {Expression Analysis of Four Long Noncoding Rnas in Breast Cancer}, journal = {Tumor Biology}, volume = {37}, number = {3}, pages = {2933-2940}, year = {2016} }
RIS	TY - JOUR AU - Iranpour M AU - Soudyab M AU - Geranpayeh L AU - Mirfakhraie R AU - Azargashb E AU - Movafagh A AU - Ghafourifard S TI - Expression Analysis of Four Long Noncoding Rnas in Breast Cancer JO - Tumor Biology VL - 37 IS - 3 SP - 2933 EP - 2940 PY - 2016 ER -

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