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Synthesis of Novel 2-Oxoquinoline Derivatives Via Ugi-Four-Component-Heck Reaction Publisher



Rasouli MA1 ; Mahdavi M2 ; Saeedi M2 ; Ranjbar PR1 ; Shafiee A2 ; Foroumadi A2, 3
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Source: Journal of Heterocyclic Chemistry Published:2015


Abstract

The present study provides an efficient strategy for the preparation of novel N-substituted-4-methyl-quinolin-1(2H)-one derivatives via two-step Ugi/Heck reaction. The procedure is based on the Ugi coupling between 2-bromoanilines, various aromatic aldehydes, vinylacetic acid, and isocyanides, and then intramolecular Heck reaction, which leads to the formation of the title compounds in good yields. © 2014 HeteroCorporation.
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