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Efficient One-Pot Synthesis of Novel 6′,9′-Dihydro-2H,7′H-Spiro[Pyrimidine-5,8′-[1,3]Dioxolo[4,5-F]Quinoline]-2,4,6(1H,3H)-Trione Derivatives Under Mild and “Green” Reaction Conditions Publisher



Ebrahimi SES1 ; Nozari N1 ; Bahadorikhalili S2 ; Yahyameymandi A3 ; Foroumadi A1 ; Larijani B4 ; Biglar M1 ; Mahdavi M4
Authors

Source: Journal of Heterocyclic Chemistry Published:2020


Abstract

In this paper, an efficient method is introduced for the synthesis of 7′,9′-disubstituted 6′,9′-dihydro-2H,7′H-spiro[pyrimidine-5,8′-[1,3]dioxolo[4,5-f]quinoline]-2,4,6(1H,3H)-trione derivatives under mild and “green” reaction conditions. The method is based on one-pot multicomponent reaction of an aldehyde, barbituric acid, and benzo[d][1,3]dioxol-5-amine in ethanol as a green and environmentally friendly solvent. The reaction has given the products in the highest isolated yield in the presence of acetic acid as catalyst under reflux conditions. Various aldehydes, bearing electron-donating or -withdrawing functionalities have been used under the optimized conditions and successfully gave the desired products (13 examples) in high isolated yields. © 2020 Wiley Periodicals LLC.
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