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Solubility of Codeine Phosphate in Carbitol + 2-Propanol Mixture at Different Temperatures Publisher Pubmed



Rezaei H1, 2 ; Jouyban A1, 3 ; Martinez F4 ; Barzegarjalali M5 ; Rahimpour E1, 6
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia—Sede Bogota, Bogota, DC, Colombia
  5. 5. Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Drug Development and Industrial Pharmacy Published:2020


Abstract

The solubility profile of codeine phosphate in the carbitol and 2-propanol mixtures at 293.2–313.2 K are determined and correlated with some developed cosolvency models. Moreover, the density values of codeine phosphate saturated solutions are also determined and fitted with the Jouyban–Acree model. The model accuracy is investigated by calculating the mean relative deviations (MRDs%). The thermodynamic parameters of codeine phosphate dissolution in the non-aqueous mixtures of carbitol and 2-propanol are also computed by using van’t Hoff and Gibbs equations. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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