Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways

Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways Publisher

Bishehsari F¹ ; Moossavi S^{2, 3, 4} ; Engen PA¹ ; Liu X⁵ ; Zhang Y⁵

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1. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, United States
2. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada
3. Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
4. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Mathematics, Statistics, and Computer Science, University of Illinois at Chicago, Chicago, IL, United States

Source: Frontiers in Oncology Published:2020

Abstract

Background: Alcohol consumption is an established risk factor for colorectal cancer (CRC). Identifying cofactor(s) that modulate the effect of alcohol on colon inflammation and carcinogenesis could help risk stratification for CRC. Disruption of circadian rhythm by light/dark shift promotes alcohol-induced colonic inflammation and cancer. More recently, we found that abnormal food timing causes circadian rhythm disruption and promotes alcohol associated colon carcinogenesis. In this study, we examined the interaction of wrong-time feeding (WTF) and alcohol on CRC-related pathways, in relation to changes in microbial community structure. Methods: Polyposis mice (TS4Cre ×cAPCΔ468) underwent four conditions: alcohol or water and feeding during the light (wrong-time fed/WTF) or during the dark (right-time fed). Colonic cecum mucosal gene expression was analyzed by RNA-seq. Microbiota 16S ribosomal RNA sequencing analysis was used to examine colonic feces. Modeling was used to estimate the extent of the gene expression changes that could be related to the changes in the colonic microbial composition. Results: The circadian rhythm pathway was the most altered pathway by the WTF treatment, indicating that WTF is disruptive to the colonic circadian rhythm. Pathway analysis revealed interaction of WTF with alcohol in dysregulating pathways related to colon carcinogenesis. Similarly, the interaction of alcohol and WTF was detected at multiple parameters of the colonic microbiota including α and β diversity, as well as the community structure. Our modeling revealed that almost a third of total gene alterations induced by our treatments could be related to alterations in the abundance of the microbial taxa. Conclusion: These data support the promoting effect of abnormal food timing alcohol-associated CRC-related pathways in the colon and suggest colon dysbiosis as a targetable mechanism. © Copyright © 2020 Bishehsari, Moossavi, Engen, Liu and Zhang.

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Style	Citing Format
MLA	Bishehsari F, et al.. "Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways." Frontiers in Oncology, vol. 10, no. , 2020, pp. -.
APA	Bishehsari F, Moossavi S, Engen PA, Liu X, Zhang Y (2020). Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways. Frontiers in Oncology, 10(), -.
Chicago	Bishehsari F, Moossavi S, Engen PA, Liu X, Zhang Y. "Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways." Frontiers in Oncology 10, no. (2020): -.
Harvard	Bishehsari F et al. (2020) 'Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways', Frontiers in Oncology, 10(), pp. -.
Vancouver	Bishehsari F, Moossavi S, Engen PA, Liu X, Zhang Y. Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways. Frontiers in Oncology. 2020;10():-.
BibTex	@article{ author = {Bishehsari F and Moossavi S and Engen PA and Liu X and Zhang Y}, title = {Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways}, journal = {Frontiers in Oncology}, volume = {10}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Bishehsari F AU - Moossavi S AU - Engen PA AU - Liu X AU - Zhang Y TI - Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways JO - Frontiers in Oncology VL - 10 IS - SP - EP - PY - 2020 ER -

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