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Reaction of Imidazo[1,2-A]Pyridines With Coumarin-3-Carboxylic Acids: A Domino Michael Addition/Decarboxylation/Oxidation/Annulation Publisher



Kianmehr E1 ; Bari B1 ; Jafarzadeh M1 ; Rostami A2 ; Golshani M3 ; Foroumadi A3
Authors
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Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, Tehran, 1417614411, Iran
  2. 2. Natural and Medical Sciences Research Center (NMSRC), University of Nizwa, Nizwa, 616, Oman
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: New Journal of Chemistry Published:2022


Abstract

A facile, metal- and additive-free C-C bond construction between imidazo[1,2-a]pyridines and coumarin-3-carboxylic acids through a decarboxylative Michael addition is reported to achieve an imidazo[1,2-a]pyridin-3-yl-chroman-2-one skeleton. In addition, heterocyclic polyaromatic dibenzoisochromenoimidazo[1,2-a]pyridin-6-ones of value for future medicinal chemistry can be obtained successfully by this procedure through a domino reaction involving Michael addition/decarboxylation/oxidation/C-H bond activation and annulation. © 2022 The Royal Society of Chemistry.