Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Long Non-Coding Rna Snar Promotes Proliferation in Egfr Wild Type Non-Small Cell Lung Cancer Cells



Mojarad MA1 ; Mojarad MA1 ; Pourmahdian A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Basic Sciences, Kharrazi University, Tehran, Iran
  2. 2. Department of Molecular Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Molecular and Cellular Medicine Published:2021

Abstract

Lung cancer is the second most common cancer and has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Over-expression of epidermal growth factor receptor (EGFR) has been clarified in different cancers, and has been shown to have a crucial role in tumor progression. In this study, we evaluated long non-coding RNA small NF90-associated RNA (snaR) expression in different EGFR-statue cell lines. Knockdown experiments were conducted to analyze snaR expression in selected cell lines. MTT and transwell assays were respectively employed to evaluate the proliferative and invasive abilities of NSCLC cells. The expression of snaR was remarkably up-regulated in SPC-A1 and A549 wild-type EGFR cell lines. Down regulation of snaR with small interfering RNA significantly inhibited cell invasion as well as proliferation of SPC-A1 and A549 cells. Our results indicate that snaR may be a potential therapeutic biomarker for NSCLC © 2021. International Journal of Molecular and Cellular Medicine.All Rights Reserved.
Related Docs
1. Role of Lncrna Pvt1 in the Progression of Urological Cancers: Novel Insights Into Signaling Pathways and Clinical Opportunities, Cellular Signalling (2025)
2. Potential Roles of Long Noncoding Rnas As Therapeutic Targets in Organ Transplantation, Frontiers in Immunology (2022)
3. Ezh2-Interacting Lncrnas Contribute to Gastric Tumorigenesis; a Review on the Mechanisms of Action, Molecular Biology Reports (2024)
4. Immunotherapeutic Targets in Non-Small Cell Lung Cancer, Immunology (2023)
5. Microrna-26B Reduces Cell Viability by Inhibition of Nicotinamide Phosphoribosyltransferase in Breast Cancer Cells, DNA and Cell Biology (2022)
6. Correlation of Tnf-Α Polymorphisms With Susceptibility to Lung Cancer: Evidence From a Meta-Analysis Based on 29 Studies, BMC Cancer (2024)
Experts (# of related papers)
View all Related Experts
Ali Akbar Amirzargar (1)
Goli Siri (1)