A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies

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A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies Publisher Pubmed

Mansouri H¹ ; Gholibegloo E² ; Mortezazadeh T³ ; Yazdi MH⁴ ; Ashouri F⁵ ; Malekzadeh R³ ; Najafi A⁶ ; Foroumadi A⁷ ; Khoobi M^{2, 7}

Show Affiliations

1. Active Pharmaceutical Ingredients Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2. Biomaterials Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran
3. Department of Medical Physics, School of Medicine, Tabriz University of Medical Science, Tabriz, Iran
4. Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Applied Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
6. Department of Immunology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran
7. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176, Iran

Source: Carbohydrate Polymers Published:2021

Abstract

A novel theranostic nanoplatform was prepared based on Fe3O4 nanoparticles (NPs) coated with gadolinium ions decorated-polycyclodextrin (PCD) layer (Fe3O4@PCD-Gd) and employed for Curcumin (CUR) loading. The dissolution profile of CUR indicated a pH sensitive release manner. Fe3O4@PCD-Gd NPs exhibited no significant toxicity against both normal and cancerous cell lines (MCF 10A and 4T1, respectively); while the CUR-free NPs showed more toxicity against 4T1 than MCF 10A cells. In vivo anticancer study revealed appropriate capability of the system in tumor shrinking with no tissue toxicity and adverse effect on body weight. In vivo MR imaging of BALB/c mouse showed both T1 and T2 contrast enhancement on the tumor cells. Fe3O4@PCD-Gd/CUR NPs showed significant features as a promising multifunctional system having appropriate T1-T2 dual contrast enhancement and therapeutic efficacy in cancer theranostics. © 2020 Elsevier Ltd

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Style	Citing Format
MLA	Mansouri H, et al.. "A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies." Carbohydrate Polymers, vol. 254, no. , 2021, pp. -.
APA	Mansouri H, Gholibegloo E, Mortezazadeh T, Yazdi MH, Ashouri F, Malekzadeh R, Najafi A, Foroumadi A, Khoobi M (2021). A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies. Carbohydrate Polymers, 254(), -.
Chicago	Mansouri H, Gholibegloo E, Mortezazadeh T, Yazdi MH, Ashouri F, Malekzadeh R, Najafi A, Foroumadi A, Khoobi M. "A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies." Carbohydrate Polymers 254, no. (2021): -.
Harvard	Mansouri H et al. (2021) 'A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies', Carbohydrate Polymers, 254(), pp. -.
Vancouver	Mansouri H, Gholibegloo E, Mortezazadeh T, Yazdi MH, Ashouri F, Malekzadeh R, et al.. A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies. Carbohydrate Polymers. 2021;254():-.
BibTex	@article{ author = {Mansouri H and Gholibegloo E and Mortezazadeh T and Yazdi MH and Ashouri F and Malekzadeh R and Najafi A and Foroumadi A and Khoobi M}, title = {A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies}, journal = {Carbohydrate Polymers}, volume = {254}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Mansouri H AU - Gholibegloo E AU - Mortezazadeh T AU - Yazdi MH AU - Ashouri F AU - Malekzadeh R AU - Najafi A AU - Foroumadi A AU - Khoobi M TI - A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies JO - Carbohydrate Polymers VL - 254 IS - SP - EP - PY - 2021 ER -

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