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Prevalence and Mechanisms of Carbapenem Resistance in Klebsiella Pneumoniae and Escherichia Coli: A Systematic Review and Meta-Analysis of Cross-Sectional Studies From Iran Publisher Pubmed



Nasiri MJ1 ; Mirsaeidi M2 ; Mousavi SMJ1 ; Arshadi M3 ; Fardsanei F4 ; Deihim B5 ; Davoudabadi S1 ; Zamani S6 ; Hajikhani B1 ; Goudarzi H1 ; Goudarzi M1 ; Seghatoleslami ZS7 ; Dabiri H1 ; Tabarsi P8
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 198396-3113, Iran
  2. 2. Division of Pulmonary, Critical Care Sleep and Allergy, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, United States
  3. 3. Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Division of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Bacteriology and Virology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran
  6. 6. Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  7. 7. Department of Infectious Diseases, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Clinical Tb and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Microbial Drug Resistance Published:2020


Abstract

Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) represents an urgent threat worldwide. We aimed to investigate the frequency of carbapenem-resistant Klebsiella pneumoniae and Escherichia coli in Iran. Materials and Methods: PubMed/Medline, Embase, Scopus, Web of Sciences, and Iranian databases were searched to find potentially relevant articles. Statistical analyses were performed using STATA version 14. Results: Forty-nine studies fulfilled the inclusion criteria. The pooled rates of resistance to carbapenem in K. pneumoniae and E. coli were 24.0% (95% confidence interval [CI] 18.0-31.0) and 5.0% (95% CI 2.0-8.0), respectively. blaOXA-48 gene was the most common cause of carbapenem resistance in K. pneumoniae and E. coli. Conclusions: CRE is prevalent in Iran, which confers the importance of strength prevention and control measures. © 2020, Mary Ann Liebert, Inc., publishers 2020.
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