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K-Doped Zno Nanostructures: Biosynthesis and Parasiticidal Application Publisher



Cao Y1 ; Alijani HQ2 ; Khatami M3, 4 ; Bagheribaravati F3 ; Iravani S5 ; Sharifi F6
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Authors Affiliations
  1. 1. School of Mechatronic Engineering, Xi'an Technological University, Xi'an, 710021, China
  2. 2. Department of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran
  3. 3. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  4. 4. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  5. 5. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

Source: Journal of Materials Research and Technology Published:2021


Abstract

In general, the growing resistance to traditional anti-leishmaniasis drugs and the ineffectiveness of appropriate treatment for leishmaniasis have prompted researchers to investigate the antiparasitic properties of plant-mediated synthesized nanomaterials and nanosystems. Potassium (K)-doped zinc oxide (ZnO) nanostructures with unique physicochemical properties can be employed as attractive candidate against this parasitic disease. In this study, K-doped zinc oxide (KdZ) nanoparticles (NPs) were synthesized using Artemisia annua extracts via an eco-friendly method with the advantages of simplicity, low cost, and up-scalability. A. annua extracts were deployed due to their antiparasitic effects. The synthesized NPs were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and transmission electron microscopy (TEM). The toxicity of these nanostructures was evaluated on Leishmania tropica and normal macrophage cells. As a result, the K-doped ZnO NPs could inhibit the L. tropica cells growth, in vitro. © 2021 The Author(s)
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