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In Vitro Bioactivity of Baghdadite-Coated Pcl –Graphene Nanocomposite Scaffolds: Mechanism of Baghdadite and Apatite Formation Publisher



Arefpour A1 ; Kasiriasgarani M1 ; Monshi A2 ; Karbasi S3 ; Doostmohammadi A4 ; Rostami S5, 6
Authors
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Authors Affiliations
  1. 1. Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  2. 2. Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
  3. 3. School of Advanced Technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Mechanical Engineering, Lassonde School of Engineering, York University, Toronto, Canada
  5. 5. Laboratory of Magnetism and Magnetic Materials, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Viet Nam
  6. 6. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam

Source: Materials Technology Published:2020


Abstract

The aim of the present research was to find out the in vitro biological behaviour by evaluating the bioactivity of scaffolds for bone tissue engineering and to examine the mechanism of baghdadite and apatite formation. For this purpose, baghdadite scaffolds with polycaprolactone and graphene nanocomposite coatings were fabricated using polymeric sponge and dip-coating methods. Results showed that regarding baghdadite formation mechanism, gittinsite phase can be converted into baghdadite phase by enhancing temperature up to 1350°C and helping Zr4+ and Ca2+. The deposit of Ca–P coatings on the surface and in the pores of the scaffolds verified the improvement of the bioactivity. Graphene in scaffold composition can affect apatite deposit formation and promise bioactivity due to its high hydrophilicity, existence of nanoparticles and great (Formula presented.) bonds in its structure. In brief, baghdadite scaffolds with polycaprolactone and graphene nanocomposite coatings can be promising outstanding candidates for bone tissue engineering. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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