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Mechanisms Controlling Ca Ion Release From Sol-Gel Derived in Situ Apatite-Silica Nanocomposite Powder



Latifi SM1, 2 ; Fathi M1, 3 ; Varshosaz J2 ; Ghochaghi N4
Authors
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Authors Affiliations
  1. 1. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, PO Box 81745-359, Isfahan, Iran
  3. 3. Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 23284, VI, United States

Source: Ceramics - Silikaty Published:2015

Abstract

Ca ion release from bioactive biomaterials could play an important role in their bioactivity and osteoconductivity properties. In order to improve hydroxyapatite (HA) dissolution rate, in situ apatite-silica nanocomposite powders with various silica contents were synthesized via sol-gel method and mechanisms controlling the Ca ion release from them were investigated. Obtained powders were characterized by X-ray diffraction (XRD) and transmission electron spectroscopy (TEM) techniques, acid dissolution test, and spectroscopy by atomic absorption spectrometer (AAS). Results indicated the possible incorporation of SiO4- into the HA structure and tendency of amorphous silica to cover the surface of HA particles. However, 20 wt. % silica was the lowest amount that fully covered HA particles. All of the nanocomposite powders showed more Ca ion release compared with pure HA, and HA - 10 wt. % silica had the highest Ca ion release. The crystallinity, the crystallite size, and the content of HA, along with the integrity, thickness, and ion diffusion possibility through the amorphous silica layer on the surface of HA, were factors that varied due to changes in the silica content and were affected the Ca ion release from nanocomposite powders.
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