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Faculty Members have conducted research related to the Optimization of Conformational Stability and Catalytic Efficiency in Chondroitinase Abc Ι by Protein Engineering Methods
Abolfazl Golestani
Abolfazl Golestani

Professor of Clinical Biochemistry

Department Biochemistry

School of Medicine

Occupational Sleep Research Center

Tehran University of Medical Sciences

Related Documents
1. Optimization of Conformational Stability and Catalytic Efficiency in Chondroitinase Abc Ι by Protein Engineering Methods, Engineering in Life Sciences (2016)
2. Role of His-His Interaction in Ser474-His475-Tyr476 Sequence of Chondroitinase Abc I in the Enzyme Activity and Stability, International Journal of Biological Macromolecules (2018)
3. Chondroitinase As a Therapeutic Enzyme: Prospects and Challenges, Enzyme and Microbial Technology (2024)
4. Unfolding of Chondroitinase Abc Ι Is Dependent on Thermodynamic Driving Force by Kinetically Rate Constant-Amplitude Compensation: A Stopped-Flow Fluorescence Study, Enzyme and Microbial Technology (2016)
5. N∆89 and C∆274 Truncated Enzymes of Chondroitinase Abc I Regain More Imperturbable Microenvironments Around Structural Components in Comparison to Their Wild Type, Protein Journal (2019)
6. Critical Role of a Loop at C-Terminal Domain on the Conformational Stability and Catalytic Efficiency of Chondroitinase Abc I, Molecular Biotechnology (2015)
7. Establishment of Aromatic Pairs at the Surface of Chondroitinase Abc I: The Effect on Activity and Stability, Applied Biochemistry and Biotechnology (2018)
8. Investigating the Role of Loop 131–140 in Activity and Thermal Stability of Chondroitinase Abc I, International Journal of Biological Macromolecules (2018)
9. Rigidifying Flexible Sites: An Approach to Improve Stability of Chondroitinase Abc I, International Journal of Biological Macromolecules (2017)
10. Improvement of Activity and Stability of Chondroitinase Abc I by Introducing an Aromatic Cluster at the Surface of Protein, Enzyme and Microbial Technology (2017)
11. Enhancing Myelin Repair in Experimental Model of Multiple Sclerosis Using Immobilized Chondroitinase Abc I on Porous Silicon Nanoparticles, International Journal of Biological Macromolecules (2020)
12. Calcium and Tnfα Additively Affect the Chondroitinase Abc I Activity, International Journal of Biological Macromolecules (2017)
13. Chondrotinase Abc I Thermal Stability Is Enhanced by Site-Directed Mutagenesis: A Molecular Dynamic Simulations Approach, Journal of Biomolecular Structure and Dynamics (2018)
All Documents
1. Unveiling the Role of Mir-186 in Sirt1 Regulation in Adipocytes: Implications for Adipogenesis and Inflammation in Obesity, Journal of Diabetes and Metabolic Disorders (2025)
2. Chondroitinase As a Therapeutic Enzyme: Prospects and Challenges, Enzyme and Microbial Technology (2024)
3. Exploring Genetic Signatures of Obesity: Hub Genes and Mirnas Unveiled Through Comprehensive Bioinformatic Analysis, Journal of Diabetes and Metabolic Disorders (2024)
4. Exploring the Impact of Naltrexone on the Thbs1/Enos/No Pathway in Osteoporotic Bile Duct-Ligated Rats, Scientific Reports (2024)
5. The Role of Sirtuin 1 in Regulation of Fibrotic Genes Expression in Pre-Adipocytes, Journal of Diabetes and Metabolic Disorders (2024)
6. A Novel Approach to Type 3 Diabetes Mechanism: The Interplay Between Noncoding Rnas and Insulin Signaling Pathway in Alzheimer's Disease, Journal of Cellular Physiology (2022)
7. Improvement of Thermostability of Cholesterol Oxidase From Streptomyces Sp. Sa-Coo by Random Mutagenesis, Protein Expression and Purification (2022)
8. Naltrexone Protects Against Bdl-Induced Cirrhosis in Wistar Rats by Attenuating Thrombospondin-1 and Enhancing Antioxidant Defense System Via Nrf-2, Life Sciences (2022)
9. The Emerging Role of Noncoding Rnas in Neuroinflammation: Implications in Pathogenesis and Therapeutic Approaches, Journal of Cellular Physiology (2022)
10. Acute Cytotoxic Effects of Titanium Dioxide (Tio2) and Chronic Exposure to Safe Dose of Nanoparticle on Hepatocarcinoma Cell Line (Hepg2), Nanomedicine Research Journal (2021)
11. Application of Supercritical Fluid Technology for Preparation of Drug Loaded Solid Lipid Nanoparticles, International Journal of Nanoscience and Nanotechnology (2020)
12. Enhancing Myelin Repair in Experimental Model of Multiple Sclerosis Using Immobilized Chondroitinase Abc I on Porous Silicon Nanoparticles, International Journal of Biological Macromolecules (2020)
13. Tumor-Derived Urinary Exosomal Long Non-Coding Rnas As Diagnostic Biomarkers for Bladder Cancer, EXCLI Journal (2020)
14. Expression Optimization, Purification, and Functional Characterization of Cholesterol Oxidase From Chromobacterium Sp. Ds1, PLoS ONE (2019)
15. N∆89 and C∆274 Truncated Enzymes of Chondroitinase Abc I Regain More Imperturbable Microenvironments Around Structural Components in Comparison to Their Wild Type, Protein Journal (2019)
16. Protein Detection of Excretory-Secretory Products and Somatic Extracts From Fasciola Hepatica and F. Gigantica Using Two-Dimensional Electrophoresis, Iranian Journal of Parasitology (2019)
17. The Influence of Trail, Adiponectin and Sclerostin Alterations on Bone Loss in Bdl-Induced Cirrhotic Rats and the Effect of Opioid System Blockade, Life Sciences (2019)
18. A Study on Opg/Rank/Rankl Axis in Osteoporotic Bile Duct-Ligated Rats and the Involvement of Nitrergic and Opioidergic Systems, Research in Pharmaceutical Sciences (2018)
19. Chondrotinase Abc I Thermal Stability Is Enhanced by Site-Directed Mutagenesis: A Molecular Dynamic Simulations Approach, Journal of Biomolecular Structure and Dynamics (2018)
20. Establishment of Aromatic Pairs at the Surface of Chondroitinase Abc I: The Effect on Activity and Stability, Applied Biochemistry and Biotechnology (2018)
21. Evidence for the Link Between Defective Autophagy and Inflammation in Peripheral Blood Mononuclear Cells of Type 2 Diabetic Patients, Journal of Physiology and Biochemistry (2018)
22. Expression Optimization of Recombinant Cholesterol Oxidase in Escherichia Coli and Its Purification and Characterization, AMB Express (2018)
23. Investigating the Role of Loop 131–140 in Activity and Thermal Stability of Chondroitinase Abc I, International Journal of Biological Macromolecules (2018)
24. Lncrna Involvement in Hepatocellular Carcinoma Metastasis and Prognosis, EXCLI Journal (2018)
25. Reduced Gene Expression of Sirtuins and Active Ampk Levels in Children and Adolescents With Obesity and Insulin Resistance, Obesity Research and Clinical Practice (2018)
26. Role of His-His Interaction in Ser474-His475-Tyr476 Sequence of Chondroitinase Abc I in the Enzyme Activity and Stability, International Journal of Biological Macromolecules (2018)
27. Thiopurine S-Methyltransferase Assay by Hplc in Acute Lymphoblastic Leukemia Patients and a Healthy Iranian Population, Acta Medica Iranica (2018)
28. Calcium and Tnfα Additively Affect the Chondroitinase Abc I Activity, International Journal of Biological Macromolecules (2017)
29. Extracellular Nampt/Visfatin Causes P53 Deacetylation Via Nad Production and Sirt1 Activation in Breast Cancer Cells, Cell Biochemistry and Function (2017)
30. Extracellular Nampt/Visfatin Induces Proliferation Through Erk1/2 and Akt and Inhibits Apoptosis in Breast Cancer Cells, Peptides (2017)
31. Improvement of Activity and Stability of Chondroitinase Abc I by Introducing an Aromatic Cluster at the Surface of Protein, Enzyme and Microbial Technology (2017)
32. Nitrergic and Opioidergic Systems Affect Radiographic Density and Histomorphometric Indices in Bile-Duct-Ligated Cirrhotic Rats, Histology and Histopathology (2017)
33. Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and Jnk/Nf-Κb Pathway in a Sirt1-Independent Mechanism, Journal of Cellular Biochemistry (2017)
34. Rigidifying Flexible Sites: An Approach to Improve Stability of Chondroitinase Abc I, International Journal of Biological Macromolecules (2017)
35. A Comparison Between the Effects of Albendazole and Meben Dazole on the Enzymatic Activity of Excretory/Secretory Prod-Ucts of Echinococcus Granulosus Protoscoleces in Vitro, Iranian Journal of Public Health (2016)
36. Erythrocytes Membrane Alterations Reflecting Liver Damage in Ccl 4 -Induced Cirrhotic Rats: The Ameliorative Effect of Naltrexone, Acta Medica Iranica (2016)
37. Improvement of Proteolytic and Oxidative Stability of Chondroitinase Abc I by Cosolvents, International Journal of Biological Macromolecules (2016)
38. Optimization of Conformational Stability and Catalytic Efficiency in Chondroitinase Abc Ι by Protein Engineering Methods, Engineering in Life Sciences (2016)
39. Regulatory Effect of Triiodothyronine on Brain Myelination and Astrogliosis After Cuprizone-Induced Demyelination in Mice, Metabolic Brain Disease (2016)
40. Selenium and Its Relationship With Selenoprotein P and Glutathione Peroxidase in Children and Adolescents With Hashimoto's Thyroiditis and Hypothyroidism, Journal of Trace Elements in Medicine and Biology (2016)
41. Undergraduate Medical Education Programme Renewal: A Longitudinal Context, Input, Process and Product Evaluation Study, Perspectives on Medical Education (2016)
42. Unfolding of Chondroitinase Abc Ι Is Dependent on Thermodynamic Driving Force by Kinetically Rate Constant-Amplitude Compensation: A Stopped-Flow Fluorescence Study, Enzyme and Microbial Technology (2016)
43. Critical Role of a Loop at C-Terminal Domain on the Conformational Stability and Catalytic Efficiency of Chondroitinase Abc I, Molecular Biotechnology (2015)
44. Effects of Heating and Acidic Solutions of Vinegar and Oxymel on Milk Coagulation for Identification and Quantification of Resulting Α-Lactalbumin and Β-Lactoglobulin Proteins in the Final Whey Product, Analytical Chemistry Letters (2015)
45. Production of Ibuprofen-Loaded Solid Lipid Nanoparticles Using Rapid Expansion of Supercritical Solution, Journal of Nano Research (2015)