Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Faculty Members have conducted research related to the Locked Nucleic Acid Anti-Mir-21 Inhibits Cell Growth and Invasive Behaviors of a Colorectal Adenocarcinoma Cell Line: Lna-Anti-Mir As a Novel Approach
Reza Nedaeinia
Reza Nedaeinia

Assistant Professor of Biotechnology

Pediatric Inherited Diseases Research Center

Research Institute for Primordial Prevention of Non-communicable Disease

Isfahan University of Medical Sciences

All Documents
1. Glp-1-Based Therapies for Type 2 Diabetes: From Single, Dual and Triple Agonists to Endogenous Glp-1 Production and L-Cell Differentiation, Diabetology and Metabolic Syndrome (2025)
2. Medicinal Chemistry of Antisense Oligonucleotides for Therapeutic Use in Sars-Cov-2: Design Strategies and Challenges for Targeted Delivery, Current medicinal chemistry (2025)
3. Clinical Implications and Prognostic Value of Leucine-Rich G Protein-Coupled Receptor 5 Expression As a Cancer Stem Cell Marker in Malignancies: A Systematic Review and Meta-Analysis, Cell Journal (2024)
4. Msc-Derived Exosomes Enhance the Anticancer Activity of Drugs in 3D Spheroid of Breast Cancer Cells, Journal of Drug Delivery Science and Technology (2024)
5. Preliminary Results of Iran Premature Coronary Artery Disease (Ipad Study) and Implementation of Ipad Biobank: A Case-Control Study, Archives of Iranian Medicine (2024)
6. The Impacts of Dipeptidyl- Peptidase 4 (Dpp-4) Inhibitors on Common Female Malignancies: A Systematic Review, Gene (2024)
7. The Role of Cancer-Associated Fibroblasts and Exosomal Mirnas-Mediated Intercellular Communication in the Tumor Microenvironment and the Biology of Carcinogenesis: A Systematic Review, Cell Death Discovery (2024)
8. Therapeutic Approaches for Type 1 Diabetes: Promising Cell-Based Approaches to Achieve Ultimate Success, SLAS Discovery (2024)
9. Comparison of Ox40 Expression in Patients With Multiple Sclerosis and Neuromyelitis Optica As an Approach to Diagnosis, Allergy, Asthma and Clinical Immunology (2023)
10. Immunotherapies Targeting Tumor Vasculature: Challenges and Opportunities, Frontiers in Immunology (2023)
11. Leptin Signaling in Breast Cancer and Its Crosstalk With Peroxisome Proliferator-Activated Receptors Α and Γ, Clinical and Translational Oncology (2023)
12. Status of Integrin Subunit Alpha 4 Promoter Dna Methylation in Colorectal Cancer and Other Malignant Tumors: A Systematic Review and Meta-Analysis, Research in Pharmaceutical Sciences (2023)
13. The Effects of Alk5 Inhibition and Simultaneous Inhibition or Activation of Hif-1Α in Melanoma Tumor Growth and Angiogenesis, Tumor Biology (2023)
14. The Nexus of Natural Killer Cells and Melanoma Tumor Microenvironment: Crosstalk, Chemotherapeutic Potential, and Innovative Nk Cell-Based Therapeutic Strategies, Cancer Cell International (2023)
15. The Role of Micrornas Involved in the Disorder of Blood–Brain Barrier in the Pathogenesis of Multiple Sclerosis, Frontiers in Immunology (2023)
16. Using in Silico Bioinformatics Algorithms for the Accurate Prediction of the Impact of Spike Protein Mutations on the Pathogenicity, Stability, and Functionality of the Sars-Cov-2 Virus and Analysis of Potential Therapeutic Targets, Biochemical Genetics (2023)
17. Association Between Colorectal Cancer and the Degree of Itga4 Promoter Methylation in Peripheral Blood Mononuclear Cells, Gene Reports (2022)
18. Correction To: Human Placental Extract Attenuates Neurological Symptoms in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis-A Putative Approach in Ms Disease? (Autoimmunity Highlights, (2020), 11, 1, (14), 10.1186/S13317-020-00137-X), Immunologic Research (2022)
19. Correction: The Dysbiosis Signature of Fusobacterium Nucleatum in Colorectal Cancer‑Cause or Consequences? a Systematic Review (Cancer Cell International, (2021), 21, 1, (194), 10.1186/S12935-021-01886-Z), Cancer Cell International (2022)
20. Effect of Anti-Podoplanin on Malignant Glioma Cell Viability, Invasion and Tumor Cell-Induced Platelet Aggregation, Archives of Medical Research (2022)
21. Evaluation of the Thermal Processes on Changing the Phenotypic Characteristics of Escherichia Coli Strains From Ice Cream Compared to Non-Pasteurized Milk, Fermentation (2022)
22. Lifestyle Genomic Interactions in Health and Disease, Integrated Science (2022)
23. Screening of Potential Inhibitors of Covid-19 With Repurposing Approach Via Molecular Docking, Network Modeling Analysis in Health Informatics and Bioinformatics (2022)
24. The Frequencies of Peripheral Blood Cd5+Cd19+ B Cells, Cd3−Cd16+Cd56+ Nk, and Cd3+Cd56+ Nkt Cells and Serum Interleukin-10 in Patients With Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder, Allergy, Asthma and Clinical Immunology (2022)
25. Unfavorable Prognosis and Clinical Consequences of Apobec3b Expression in Breast and Other Cancers: A Systematic Review and Meta-Analysis, Tumor Biology (2022)
26. An Integrated Bioinformatics Analysis of the Potential Regulatory Effects of Mir-21 on T-Cell Related Target Genes in Multiple Sclerosis, Avicenna Journal of Medical Biotechnology (2021)
27. Assessment of Heavy Metal Contamination in Herbal Medicinal Products Consumed in the Iranian Market, Environmental Science and Pollution Research (2021)
28. The Dysbiosis Signature of Fusobacterium Nucleatum in Colorectal Cancer-Cause or Consequences? a Systematic Review, Cancer Cell International (2021)
29. The Prevalence of Ataxia Telangiectasia Mutated (Atm) Variants in Patients With Breast Cancer Patients: A Systematic Review and Meta-Analysis, Cancer Cell International (2021)
30. The Prevalence of Ataxia Telangiectasia Mutated (Atm) Variants in Patients With Breast Cancer Patients: A Systematic Review and Meta-Analysis, Cancer Cell International (2021)
31. The Role of Hypoxia in the Tumor Microenvironment and Development of Cancer Stem Cell: A Novel Approach to Developing Treatment, Cancer Cell International (2021)
32. Association Between the Microbiota and Women's Cancers – Cause or Consequences?, Biomedicine and Pharmacotherapy (2020)
33. Bacterial Staphylokinase As a Promising Third-Generation Drug in the Treatment for Vascular Occlusion, Molecular Biology Reports (2020)
34. Cerium Oxide Nanoparticles: A Promising Tool for the Treatment of Fibrosarcoma In-Vivo, Materials Science and Engineering C (2020)
35. Construction of a Sensitive and Specific Lead Biosensor Using a Genetically Engineered Bacterial System With a Luciferase Gene Reporter Controlled by Pbr and Cada Promoters, BioMedical Engineering Online (2020)
36. Designing a Multifunctional Staphylokinase Variant (Sak-2Rgd-Tti) With Appropriate Thrombolytic Activity in Vitro, Biotechnology Letters (2020)
37. Human Placental Extract Attenuates Neurological Symptoms in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis-A Putative Approach in Ms Disease?, Autoimmunity Highlights (2020)
38. Identification of an Immunoglobulin M (Igm) Antibody Against Enolase 1 Protein (Eno1) Derived From Hek-293 Cells in Patients With Kidney Failure, International Journal of Peptide Research and Therapeutics (2020)
39. Rapid Noninvasive Detection of Bladder Cancer Using Survivin Antibody-Conjugated Gold Nanoparticles (Gnps) Based on Localized Surface Plasmon Resonance (Lspr), Cancer Immunology, Immunotherapy (2020)
40. Therapeutic Inhibition of Microrna-21 (Mir-21) Using Locked-Nucleic Acid (Lna)-Anti-Mir and Its Effects on the Biological Behaviors of Melanoma Cancer Cells in Preclinical Studies, Cancer Cell International (2020)
41. Evaluation of Anticancer Effects of Cerium Oxide Nanoparticles on Mouse Fibrosarcoma Cell Line, Journal of Cellular Physiology (2019)
42. Evaluation of the Frequency of Cd5+ B Cells As Natural Immunoglobulin M Producers and Circulating Soluble Cd5 in Patients With Bladder Cancer, Molecular Biology Reports (2019)
43. Evaluation of the Frequency of Cd5+ B Cells As Natural Immunoglobulin M Producers and Circulating Soluble Cd5 in Patients With Bladder Cancer, Molecular Biology Reports (2019)
44. A Review on Application of Novel Solid Nanostructures in Drug Delivery, Journal of Nano Research (2018)
45. Circulating Exosomes and Exosomal Micrornas As Biomarkers in Gastrointestinal Cancer, Cancer Gene Therapy (2017)
46. Current Status and Perspectives Regarding Lna-Anti-Mir Oligonucleotides and Microrna Mir-21 Inhibitors As a Potential Therapeutic Option in Treatment of Colorectal Cancer, Journal of Cellular Biochemistry (2017)
47. Inhibition of Microrna-21 Via Locked Nucleic Acid-Anti-Mir Suppressed Metastatic Features of Colorectal Cancer Cells Through Modulation of Programmed Cell Death 4, Tumor Biology (2017)
48. Association Between Serum Cytokine Concentrations and the Presence of Hypertriglyceridemia, Clinical Biochemistry (2016)
49. Early Detection of Colorectal Cancer: From Conventional Methods to Novel Biomarkers, Journal of Cancer Research and Clinical Oncology (2016)
50. Locked Nucleic Acid Anti-Mir-21 Inhibits Cell Growth and Invasive Behaviors of a Colorectal Adenocarcinoma Cell Line: Lna-Anti-Mir As a Novel Approach, Cancer Gene Therapy (2016)
51. The Association of High Risk Human Papillomaviruses in Patients With Cervical Cancer: An Evidence Based Study on Patients With Squamous Cell Dysplasia or Carcinoma for Evaluation of 23 Human Papilloma Virus Genotypes, Jundishapur Journal of Microbiology (2016)
52. The Association of High Risk Human Papillomaviruses in Patients With Cervical Cancer: An Evidence Based Study on Patients With Squamous Cell Dysplasia or Carcinoma for Evaluation of 23 Human Papilloma Virus Genotypes, Jundishapur Journal of Microbiology (2016)
53. Egfr As a Potential Target for the Treatment of Pancreatic Cancer: Dilemma and Controversies, Current Drug Targets (2014)