Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Identification of New Hsp90 Inhibitors: Structure Based Virtual Screening, Molecular Dynamic Simulation, Synthesis and Biological Evaluation
Mahmoud Aghaei
Mahmoud Aghaei

Professor of Clinical Biochemistry

Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences

Pharmaceutical Sciences Research Center

Isfahan University of Medical Sciences

All Documents
1. Dihydropyrimidine Derivatives As Mdm2 Inhibitors, Chemical Biology and Drug Design (2024)
2. Discovery of New 13(17)-Epoxymyrsinane Diterpenes From Aerial Flowering Parts of Euphorbia Spinidens Bornm. Ex Prokh. With Proapoptotic Activities Against Human Bladder Cancer Ej138 Cells, Natural Product Research (2024)
3. Malleatin a and B: New Premyrsine-Type Diterpenes From Euphorbia Malleata With Cytotoxic Effects Against A2780 Wild and A2780 R-Cis Ovarian Cancer Cell Lines in Mono or Combination Treatment With Cisplatin, Iranian Journal of Pharmaceutical Research (2024)
4. New Amide and Diterpene Alkaloids With Anticholinesterase Activity From Delphinium Cyphoplectrum Roots, DARU, Journal of Pharmaceutical Sciences (2024)
5. Α2β1 Integrin Specific Inhibitor Btt-3033 Promotes Paclitaxel-Induced Apoptosis in Human Ovarian Cancer Cells, Research in Pharmaceutical Sciences (2024)
6. Cycloartane Triterpenoid From Euphorbia Macrostegia Modulates Er Stress Signaling Pathways to Induce Apoptosis in Mda-Mb231 and Mcf-7 Breast Cancer Cell Lines, Naunyn-Schmiedeberg's Archives of Pharmacology (2023)
7. Evaluation of the Flavonol-Rich Fraction of Rosa Damascena in an Animal Model of Liver Fibrosis by Targeting the Expression of Fibrotic Cytokines, Antioxidant/Oxidant Ratio and Collagen Cross-Linking, Life Sciences (2023)
8. Heat Shock Proteins and Cancer: The Foxm1 Connection, Biochemical Pharmacology (2023)
9. Mir-1236: Key Controller of Tumor Development and Progression: Focus on the Biological Functions and Molecular Mechanisms, Pathology Research and Practice (2023)
10. Molecular Mechanisms of Mir-1236 in the Assessment of Tumor Lymphangiogenesis in Human Ovarian Cancer Patients, Journal of Gene Medicine (2023)
11. Molecular Mechanisms of Mir-1236 in the Assessment of Tumor Lymphangiogenesis in Human Ovarian Cancer Patients, Journal of Gene Medicine (2023)
12. Preparation and Characterisation of a New Form of Silymarin As a Potential Antidiabetic Agent in the Adult Male Rat, Archives of Physiology and Biochemistry (2023)
13. Sar131675 Exhibits Anticancer Activity on Human Ovarian Cancer Cells Through Inhibition of Vegfr-3/Erk1/2/Akt Signaling Pathway, Cellular Signalling (2023)
14. Vegfr3 Suppression Through Mir-1236 Inhibits Proliferation and Induces Apoptosis in Ovarian Cancer Via Erk1/2 and Akt Signaling Pathways, Journal of Cellular Biochemistry (2023)
15. Beneficial Effects of Mgso4 on Tfam, Upc3 and Fndc5 Mrna Expressions in Skeletal Muscle of Type 2 Diabetic Rats: A Possible Mechanism to Improve Insulin Resistance, Molecular Biology Reports (2022)
16. Caveolae-Dependent Endocytosis Mediates the Cellular Uptake of Cdte Quantum Dots in Ovarian Cancer Cell Lines, Research in Pharmaceutical Sciences (2022)
17. Long-Term Gaba Administration Improves Fndc5, Tfam, and Ucp3 Mrna Expressions in the Skeletal Muscle and Serum Irisin Levels in Chronic Type 2 Diabetic Rats, Naunyn-Schmiedeberg's Archives of Pharmacology (2022)
18. Mitochondrial Pro-Apoptotic Properties of Sinularia Compressa From Persian Gulf Against Breast Cancer Cells and Its Chemical Composition, Nutrition and Cancer (2022)
19. New Cytotoxic Premyrsinane-Type Diterpenes From Euphorbia Aleppica Against Breast Cancer Cells, Iranian Journal of Pharmaceutical Research (2022)
20. Nisin Induces Apoptosis in Cervical Cancer Cells Via Reactive Oxygen Species Generation and Mitochondrial Membrane Potential Changes, Biochemistry and Cell Biology (2022)
21. Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines, Natural Product Research (2022)
22. Phytochemical Analysis of Artemisia Kopetdaghensis: Sesquiterpene Lactones With Proapoptotic Activity Against Prostate Cancer Cells, Phytochemistry (2022)
23. Phytochemical Analysis of Daphne Pontica L. Stems With Their Pro-Apoptotic Properties Against Du-145 and Lncap Prostate Cancer Cells, DARU, Journal of Pharmaceutical Sciences (2022)
24. Preparation and Evaluation of Targeted Albumin Lipid Nanoparticles With Lactobionic Acid for Targeted Drug Delivery of Sorafenib in Hepatocellular Carcinoma, Journal of Drug Delivery Science and Technology (2022)
25. Sar131675 Receptor Tyrosine Kinase Inhibitor Induces Apoptosis Through Bcl-2/Bax/Cyto C Mitochondrial Pathway in Human Umbilical Vein Endothelial Cells, Anti-Cancer Agents in Medicinal Chemistry (2022)
26. The Role of Irisin in Various Organs of the Human Body With Emphasis on the Beneficial Effects on Glucose Homeostasis, Journal of Isfahan Medical School (2022)
27. 15-Hydroxy-8(17),13(E)-Labdadiene-19-Carboxylic Acid (Hlca) Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis in Ovarian Cancer Cells, Life Sciences (2021)
28. 4-Hydroxyhalcone Effects on Cisplatin-Induced Genotoxicity Model, Toxicology Research (2021)
29. 6-Methoxylated Flavonoids: Jacein, and 3-Demethyljacein From Centaurea Schmidii With Their Endoplasmic Reticulum Stress and Apoptotic Cell Death in Breast Cancer Cells Along With In-Silico Analysis, Iranian Journal of Pharmaceutical Research (2021)
30. Anticancer Activity of Delphinium Semibarbatum Alkaloid Fractions Against Lncap, and Du 145 Human Prostate Cancer Cells Through the Intrinsic Apoptotic Pathway, Iranian Journal of Pharmaceutical Research (2021)
31. Galectin-9 Inhibits Cell Proliferation and Induces Apoptosis in Jurkat and Ke-37 Acute Lymphoblastic Leukemia Cell Lines Via Caspase-3 Activation, Research in Pharmaceutical Sciences (2021)
32. Identification of New Hsp90 Inhibitors: Structure Based Virtual Screening, Molecular Dynamic Simulation, Synthesis and Biological Evaluation, Anti-Cancer Agents in Medicinal Chemistry (2021)
33. Identification of New Hsp90 Inhibitors: Structure Based Virtual Screening, Molecular Dynamic Simulation, Synthesis and Biological Evaluation, Anti-Cancer Agents in Medicinal Chemistry (2021)
34. Integrin Α2β1 Inhibition Attenuates Prostate Cancer Cell Proliferation by Cell Cycle Arrest, Promoting Apoptosis and Reducing Epithelial–Mesenchymal Transition, Journal of Cellular Physiology (2021)
35. Microrna-30C-2-3P Regulates Er Stress and Induces Apoptosis in Ovarian Cancer Cells Underlying Er Stress, EXCLI Journal (2021)
36. New Diterpene Compound From Euphorbia Connate Boiss., 3,7,14,15-Tetraacetyl-5-Propanoyl-13(17)-Epoxy-8,10(18)-Myrsinadiene, Inhibits the Growth of Ovarian Cancer Cells by Promoting Mitochondrial-Mediated Apoptosis, Nutrition and Cancer (2021)
37. Synergistic Anti-Proliferative Effects of Lenalidomide and Dexamethasone on the Ht-29 Cell Line Through Apoptotic Genes, International Journal of Cancer Management (2021)
38. The Er Stress/Upr Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis, Life (2021)
39. The Role of Bip and the Ire1α–Xbp1 Axis in Rhabdomyosarcoma Pathology, Cancers (2021)
40. The Role of Bip and the Ire1α–Xbp1 Axis in Rhabdomyosarcoma Pathology, Cancers (2021)
41. A New Sesquiterpenoid From the Shoots of Iranian Daphne Mucronata Royle With Selective Inhibition of Stat3 and Smad3/4 Cancer-Related Signaling Pathways, DARU# Journal of Pharmaceutical Sciences (2020)
42. A New Sesquiterpenoid From the Shoots of Iranian Daphne Mucronata Royle With Selective Inhibition of Stat3 and Smad3/4 Cancer-Related Signaling Pathways, DARU, Journal of Pharmaceutical Sciences (2020)
43. Down-Regulation of Ddr1 Induces Apoptosis and Inhibits Emt Through Phosphorylation of Pyk2/Mkk7 in Du-145 and Lncap-Fgc Prostate Cancer Cell Lines, Anti-Cancer Agents in Medicinal Chemistry (2020)
44. Kopetdaghinanes, Pro-Apoptotic Hemiacetialic Cyclomyrsinanes From Euphorbia Kopetdaghi, Fitoterapia (2020)
45. Kopetdaghinanes, Pro-Apoptotic Hemiacetialic Cyclomyrsinanes From Euphorbia Kopetdaghi, Fitoterapia (2020)
46. Mechanism of Inositol-Requiring Enzyme 1-Alpha Inhibition in Endoplasmic Reticulum Stress and Apoptosis in Ovarian Cancer Cells, Journal of Cell Communication and Signaling (2020)
47. New Heat Shock Protein (Hsp90) Inhibitors, Designed by Pharmacophore Modeling and Virtual Screening: Synthesis, Biological Evaluation and Molecular Dynamics Studies, Journal of Biomolecular Structure and Dynamics (2020)
48. New Heat Shock Protein (Hsp90) Inhibitors, Designed by Pharmacophore Modeling and Virtual Screening: Synthesis, Biological Evaluation and Molecular Dynamics Studies, Journal of Biomolecular Structure and Dynamics (2020)
49. Purification of Soluble Membrane-Bound Ambystoma Mexicanum Epidermal Lipoxygenase From E. Coli and Its Growth Effect on Human Fetal Foreskin Fibroblast, Protein Journal (2020)
50. Simvastatin Increases Temozolomide-Induced Cell Death by Targeting the Fusion of Autophagosomes and Lysosomes, FEBS Journal (2020)
51. Study of T-Cell Immunoglobulin and Mucin Domain-3 Expression Profile in Peripheral Blood and Bone Marrow of Human Acute Lymphoblastic Leukemia Patients, Journal of Research in Medical Sciences (2020)
52. Study of T-Cell Immunoglobulin and Mucin Domain-3 Expression Profile in Peripheral Blood and Bone Marrow of Human Acute Lymphoblastic Leukemia Patients, Journal of Research in Medical Sciences (2020)
53. Two New Dammarane Triterpenes Isolated From Cleome Khorassanica Bunge & Bien With Cytotoxicity Against Du-145 and Lncap Prostate Cancer Cell Lines, Journal of Asian Natural Products Research (2020)
54. A2a Adenosine Receptor Agonist Improves Endoplasmic Reticulum Stress in Min6 Cell Line Through Protein Kinase A/ Protein Kinase B/ Cyclic Adenosine Monophosphate Response Element-Binding Protein/ and Growth Arrest and Dna-Damage-Inducible 34/ Eukaryotic Initiation Factor 2Α Pathways, Journal of Cellular Physiology (2019)
55. A3 Receptor Agonist, Cl-Ibmeca, Potentiate Glucose-Induced Insulin Secretion From Min6 Insulinoma Cells Possibly Through Transient Ca2+ Entry, Research in Pharmaceutical Sciences (2019)
56. Adenosine Protects Pancreatic Beta Cells Against Apoptosis Induced by Endoplasmic Reticulum Stress, Journal of Cellular Biochemistry (2019)
57. Anticancer Activity of Britannin Through the Downregulation of Cyclin D1 and Cdk4 in Human Breast Cancer Cells, Journal of Cancer Research and Therapeutics (2019)
58. Centaurea Cyanus Extracted 13-O-Acetylsolstitialin a Decrease Bax/Bcl-2 Ratio and Expression of Cyclin D1/Cdk-4 to Induce Apoptosis and Cell Cycle Arrest in Mcf-7 and Mda-Mb-231 Breast Cancer Cell Lines, Journal of Cellular Biochemistry (2019)
59. Evidences for Involvement of Estrogen Receptor Induced Erk1/2 Activation in Ovarian Cancer Cell Proliferation by Cadmium Chloride, Toxicology in Vitro (2019)
60. Inhibition of Didscoidin Domain Receptor 1 Reduces Epithelial–Mesenchymal Transition and Induce Cell-Cycle Arrest and Apoptosis in Prostate Cancer Cell Lines, Journal of Cellular Physiology (2019)
61. Ipp-1 Controls Akt/Creb Phosphorylation Extension in A2a Adenosine Receptor Signaling Cascade in Min6 Pancreatic Β-Cell Line, European Journal of Pharmacology (2019)
62. Lhrh Targeted Chonderosomes of Mitomycin C in Breast Cancer: An in Vitro/ in Vivo Study, Anti-Cancer Agents in Medicinal Chemistry (2019)
63. Mechanisms of Simvastatin Myotoxicity: The Role of Autophagy Flux Inhibition, European Journal of Pharmacology (2019)
64. Sesquiterpene Lactones From Shoot Culture of Artemisia Aucheri With Cytotoxicity Against Prostate and Breast Cancer Cells, Research in Pharmaceutical Sciences (2019)
65. A New Taraxastane Triterpene From Euphorbia Denticulata With Cytotoxic Activity Against Prostate Cancer Cells, Iranian Journal of Pharmaceutical Research (2018)
66. A2b Adenosine Receptor Agonist Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Stem Cells Via Erk1/2 Phosphorylation, Cellular Oncology (2018)
67. Cadmium Induces Progesterone Receptor Gene Expression Via Activation of Estrogen Receptor in Human Ovarian Cancer Cells, Research in Pharmaceutical Sciences (2018)
68. Cadmium Telluride Quantum Dots Induce Apoptosis in Human Breast Cancer Cell Lines, Toxicology and Industrial Health (2018)
69. Cytotoxic Effect of Drimia Maritima Bulb Extract and Induction of Mitochondrial Apoptotic Signaling in Human Breast Cancer Cells, Mcf-7 and Mda-Mb-468, OncoTargets and Therapy (2018)
70. Estrogen Stimulates Adenosine Receptor Expression Subtypes in Human Breast Cancer Mcf-7 Cell Line, Research in Pharmaceutical Sciences (2018)
71. Galectin-9 Induces Apoptosis in Ovcar-3 Ovarian Cancer Cell Through Mitochondrial Pathway, Research in Pharmaceutical Sciences (2018)
72. Leptin Induces Matrix Metalloproteinase 7 Expression to Promote Ovarian Cancer Cell Invasion by Activating Erk and Jnk Pathways, Journal of Cellular Biochemistry (2018)
73. Mitochondrial and Caspase Pathways Are Involved in the Induction of Apoptosis by Nardosinen in Mcf-7 Breast Cancer Cell Line, Research in Pharmaceutical Sciences (2018)
74. Pimpinelol, a Novel Atypical Sesquiterpene Lactone From Pimpinella Haussknechtii Fruits With Evaluation of Endoplasmic Reticulum Stress in Breast Cancer Cells, Fitoterapia (2018)
75. Synthesis and Cytotoxicity Assessment of Gold-Coated Magnetic Iron Oxide Nanoparticles, Journal of Biomedical Physics and Engineering (2018)
76. The Protective Role of Melatonin in Cadmium-Induced Proliferation of Ovarian Cancer Cells, Research in Pharmaceutical Sciences (2018)
77. A3 Adenosine Receptor Agonist Induce G1 Cell Cycle Arrest Via Cyclin D and Cyclin-Dependent Kinase 4 Pathways in Ovcar-3 and Caov-4 Cell Lines, Journal of Cancer Research and Therapeutics (2017)
78. A3 Adenosine Receptor Agonist Inhibited Survival of Breast Cancer Stem Cells Via Gli-1 and Erk1/2 Pathway, Journal of Cellular Biochemistry (2017)
79. Apoptosis and Cell Cycle Regulatory Effects of Adenosine by Modulation of Gli-1 and Erk1/2 Pathways in Cd44+ and Cd24− Breast Cancer Stem Cells, Cell Proliferation (2017)
80. Association of Serum Microrna-21 Levels With Visfatin, Inflammation, and Acute Coronary Syndromes, Heart and Vessels (2017)
81. Dihydroartemisinin Induces Apoptosis in Human Bladder Cancer Cell Lines Through Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cytochrome C Pathway, International Journal of Preventive Medicine (2017)
82. Effect of Pufas Oral Administration on the Amount of Apoptotic Caspases Enzymes in Gastric Cancer Patients Undergoing Chemotherapy, Anti-Cancer Agents in Medicinal Chemistry (2017)
83. Induction of G2/M Phase Arrest and Apoptosis by a New Tetrahydroingenol Diterpenoid From Euphorbia Erythradenia Bioss. in Melanoma Cancer Cells, Biomedicine and Pharmacotherapy (2017)
84. Jatropha-6(17),11 E -Diene Class Derivatives Induce Apoptosis Effects in Ovcar-3 and Caov-4 Ovarian Cancer Cell Lines Via a Mitochondrial Pathway, Biochemistry and Cell Biology (2017)
85. New 6(17)-Epoxylathyrane Diterpene: Aellinane From Euphorbia Aellenii Induces Apoptosis Via Mitochondrial Pathway in Ovarian Cancer Cell Line, Toxicology Mechanisms and Methods (2017)
86. New 6(17)-Epoxylathyrane Diterpene: Aellinane From Euphorbia Aellenii Induces Apoptosis Via Mitochondrial Pathway in Ovarian Cancer Cell Line, Toxicology Mechanisms and Methods (2017)
87. Rhoa/Rock Pathway Mediates Leptin-Induced Upa Expression to Promote Cell Invasion in Ovarian Cancer Cells, Cellular Signalling (2017)
88. Aptamer-Conjugated Magnetic Nanoparticles As Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer, Journal of Medical Signals and Sensors (2016)
89. Bioactivity-Guided Isolation of New Antiproliferative Compounds From Juniperus Foetidissima Willd, Natural Product Research (2016)
90. New Macrocyclic Diterpenes From Euphorbia Connata Boiss. With Cytotoxic Activities on Human Breast Cancer Cell Lines, Natural Product Research (2016)
91. Obtusifoliol Related Steroids From Euphorbia Sogdiana With Cell Growth Inhibitory Activity and Apoptotic Effects on Breast Cancer Cells (Mcf-7 and Mda-Mb231), Steroids (2016)
92. The Effect of Ω-Fatty Acids on the Expression of Phospholipase A2 Group 2A in Human Gastric Cancer Patients, Journal of Research in Medical Sciences (2016)
93. The Role of Serum Levels of Microrna-21 and Matrix Metalloproteinase-9 in Patients With Acute Coronary Syndrome, Molecular and Cellular Biochemistry (2016)
94. Activation of A2b Adenosine Receptor Regulates Ovarian Cancer Cell Growth: Involvement of Bax/Bcl-2 and Caspase-3, Biochemistry and Cell Biology (2015)
95. Britannin, a Sesquiterpene Lactone, Inhibits Proliferation and Induces Apoptosis Through the Mitochondrial Signaling Pathway in Human Breast Cancer Cells, Tumor Biology (2015)
96. Cadmium Induces Reactive Oxygen Species-Dependent Apoptosis in Mcf-7 Human Breast Cancer Cell Line, Toxicology Mechanisms and Methods (2015)
97. Cytotoxic Activities of Euphorbia Kopetdaghi Against Ovcar-3 and Ej-138 Cell Lines, Journal of HerbMed Pharmacology (2015)
98. Evaluating T-Cell Immunoglobulin Mucin-3 (Tim-3) Receptor in the Growth Inhibition of Acute Lymphoblastic Leukemia (All) Cell Lines, Journal of Isfahan Medical School (2015)
99. Expression of Adenosine Receptor Subclasses in Malignant and Adjacent Normal Human Prostate Tissues, Prostate (2015)
100. Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles, Annals of Dermatology (2015)
101. Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles, Annals of Dermatology (2015)
102. Molecular Expression of Adenosine Receptors in Ovcar-3, Caov-4 and Skov-3 Human Ovarian Cancer Cell Lines, Research in Pharmaceutical Sciences (2015)
103. Molecular Mechanism of Apoptosis Induction by Gaillardin, a Sesquiterpene Lactone, in Breast Cancer Cell Lines: Gaillardin-Induced Apoptosis in Breast Cancer Cell Lines, Cell Biology and Toxicology (2015)
104. New Jatrophane Diterpenes From Euphorbia Osyridea With Proapoptotic Effects on Ovarian Cancer Cells, Phytochemistry Letters (2015)
105. Cycloartane Triterpenoids From Euphorbia Macrostegia With Their Cytotoxicity Against Mda-Mb48 and Mcf-7 Cancer Cell Lines, Iranian Journal of Pharmaceutical Research (2014)
106. Investigation of Cadmium Chloride Cytotoxic Effect in Mcf-7 Breast Cancer Cell Line, Journal of Isfahan Medical School (2014)
107. Mitochondrial and Caspase Pathways Are Involved in the Induction of Apoptosis by Ib-Meca in Ovarian Cancer Cell Lines, Tumor Biology (2014)
108. Adenosine Induces Cell Cycle Arrest and Apoptosis Via Cyclind1/Cdk4 and Bcl-2/Bax Pathways in Human Ovarian Cancer Cell Line Ovcar-3, Tumor Biology (2013)
109. Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of Erk and Akt Pathways, Journal of Cosmetic Dermatology (2013)
110. Intakes of Vegetables and Fruits Are Negatively Correlated With Risk of Stroke in Iran, International Journal of Preventive Medicine (2013)
111. Quercetin Supplementation Does Not Attenuate Exercise Performance and Body Composition in Young Female Swimmers, International Journal of Preventive Medicine (2013)
112. Unusual Ingenoids From Euphorbia Erythradenia Bioss. With Pro-Apoptotic Effects, Fitoterapia (2013)
113. Adenosine Induces Cell-Cycle Arrest and Apoptosis in Androgen-Dependent And-Independent Prostate Cancer Cell Lines, Lncap-Fgc-10, Du-145, and Pc3, Prostate (2012)
114. Evaluation of Pde5 and Pde9 Expression in Benign and Malignant Breast Tumors, Archives of Medical Research (2012)
115. Inhibition of Phosphodiestrase 9 Induces Cgmp Accumulation and Apoptosis in Human Breast Cancer Cell Lines, Mcf-7 and Mda-Mb-468, Cell Proliferation (2012)
116. Molecular Mechanisms of A3 Adenosine Receptor-Induced G1 Cell Cycle Arrest and Apoptosis in Androgen-Dependent and Independent Prostate Cancer Cell Lines: Involvement of Intrinsic Pathway, Journal of Cancer Research and Clinical Oncology (2011)