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Regional Burden of Chronic Kidney Disease in North Africa and Middle East During 1990–2019; Results From Global Burden of Disease Study 2019 Publisher Pubmed



Tabatabaeimalazy O1, 2 ; Saeedi Moghaddam S1 ; Khashayar P3, 4 ; Keykhaei M1, 5 ; Tehrani YS1 ; Malekpour MR1 ; Esfahani Z1, 6 ; Rashidi MM1 ; Golestani A1 ; Shobeiri P1 ; Moghimi M1 ; Gorgani F1 ; Abdolhamidi E1 ; Farzadfar F1, 2 Show All Authors
Authors
  1. Tabatabaeimalazy O1, 2
  2. Saeedi Moghaddam S1
  3. Khashayar P3, 4
  4. Keykhaei M1, 5
  5. Tehrani YS1
  6. Malekpour MR1
  7. Esfahani Z1, 6
  8. Rashidi MM1
  9. Golestani A1
  10. Shobeiri P1
  11. Moghimi M1
  12. Gorgani F1
  13. Abdolhamidi E1
  14. Farzadfar F1, 2
  15. Larijani B2
Show Affiliations
Authors Affiliations
  1. 1. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Osteoporosis Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Center for Microsystems Technology, Imec and Ghent University, Gent, Belgium
  5. 5. Feinberg School of Medicine, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, United States
  6. 6. Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

Source: Frontiers in Public Health Published:2022


Abstract

Objectives: Updating burden data of chronic kidney disease (CKD) as one of the most prevalent non-communicable diseases is essential for proper provision of healthcare by policymakers. We aimed to estimate the burden of CKD and its attributed burden in North Africa and Middle East region (NAME) during 1990–2019. Methods: The CKD-related Global Burden of Disease (GBD) 2019 estimates were extracted from Health Metrics and Evaluation (IHME) website. Results: In 2019, 2,034,879 new CKD cases (95% Uncertainty interval 1,875,830 to 2,202,724) with an age-standardized incidence rate of 447.5 (415.1 to 482.8) per 100,000 was reported, showing a 70.9% increase in the past 30 years. CKD led to 111,812 deaths (96,421 to 130,853) with an age-standardized rate of 30.4 (26.3 to 35.4) per 100,000. The highest increase and decrease in the mortality rate were estimated in Morocco 21.8% (−8.9 to 51.6) and Kuwait −41.5% (−51.2 to −29.1). In 2019, CKD was responsible for 744.4 (646.1 to 851.8) age-standardized disability-adjusted life years (DALYs), mostly contributed to “other and unspecified causes” [237.2 (191.1 to 288.4)], type 2 diabetes [205.9 (162.4 to 253.6)], and hypertension [203.3 (165.8 to 243)]. An increase was noted in DALYs from ages 25–29 and surged with an accelerating pattern by age. Kidney dysfunction, high systolic blood pressure, and high body mass index ranked as the top three risk factors for the disorder. Conclusions: Our study raised an alarm regarding the increasing CKD burden in NAME. There is an urgency to deal with hypertension and overweight/obesity at the primary care level, implementing CKD screening for at-risk groups, and facilitating the accessibility to appropriate treatments. Copyright © 2022 Tabatabaei-Malazy, Saeedi Moghaddam, Khashayar, Keykhaei, Tehrani, Malekpour, Esfahani, Rashidi, Golestani, Shobeiri, Moghimi, Gorgani, Abdolhamidi, Farzadfar and Larijani.
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