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Comprehensive Assessment of Nutritional Status and Nutritional-Related Complications in Newly Diagnosed Esophageal Cancer Patients: A Cross-Sectional Study Publisher Pubmed



Movahed S1, 2 ; Varshoee Tabrizi F3 ; Pahlavani N1, 2 ; Seilanian Toussi M4 ; Motlagh A5 ; Eslami S6 ; Ghayourmobarhan M7 ; Nematy M1 ; Ferns GA8 ; Emadzadeh M9 ; Khademrezaiyan M10 ; Alavi AH11 ; Salek M12 ; Zabeti P12 Show All Authors
Authors
  1. Movahed S1, 2
  2. Varshoee Tabrizi F3
  3. Pahlavani N1, 2
  4. Seilanian Toussi M4
  5. Motlagh A5
  6. Eslami S6
  7. Ghayourmobarhan M7
  8. Nematy M1
  9. Ferns GA8
  10. Emadzadeh M9
  11. Khademrezaiyan M10
  12. Alavi AH11
  13. Salek M12
  14. Zabeti P12
  15. Norouzy A1
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Students Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Reza Radiotherapy and Oncology Center, Mashhad, Iran
  4. 4. Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Radiotherapy, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, BN1 9PH, Sussex, United Kingdom
  9. 9. Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Clinical Research Development Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Department of Nutrition, Varastegan Institute for Medical Sciences, Mashhad, Iran

Source: Clinical Nutrition Published:2021


Abstract

Background & aims: Malnutrition is prevalent in upper gastrointestinal cancer patients. The purpose of this study was a comprehensive assessment of nutritional status in newly diagnosed patients with esophageal cancer. Methods: Newly diagnosed esophageal cancer patients were referred to a chemo-radiation referral center in Mashhad, Iran, between February 2017 to February 2019. Anthropometric indices, a Patient-Generated Subjective Global Assessment (PG-SGA) tool, body composition, dietary intake, nutritional-related complications, and laboratory tests were assessed. Results: One hundred and eighty-nine patients with a mean age of 67.1 ± 12 and a male to female ratio of 98 to 91 were included. Ninety-seven (51.3%) of patients had experienced significant weight loss and 56 (29.6%) were underweight at diagnosis. According to PG-SGA, 179 (94.7%) needed nutritional interventions. Reduced muscle mass and low handgrip strength were observed in 70 (39.4%) and 26 (14.4%) of patients, respectively. Inadequate intakes of energy (less than 24 kcal/kg/day) and protein (less than 1.2 g/kg/day) were found in 146 (77.8%) and 171 (91%) patients, respectively. The mean total daily energy and protein intakes of subjects were 943.8 ± 540 kcal/day, and 30.6 ± 21 g/day, respectively. The most common nutritional-related complications were as follows: dysphagia (84.8%), anorexia (31.6%), constipation (62.1%), esophageal pain (48.4%), and dyspepsia (41.1%). Conclusion: Our study demonstrated a high prevalence of malnutrition in newly diagnosed esophageal cancer patients. This fact demonstrates the importance of early screening of nutritional status via PG-SGA tool, clinical evaluation, dietary intake evaluations, and laboratory tests, based on which effective nutritional interventions and Symptoms management may be introduced in these patients. © 2021
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