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Ring-Opening Cross-Coupling/Cyclization Reaction of Cyclopropanols With Organic Compounds Publisher



Doraghi F1 ; Pegah Aledavoud S1 ; Fakhrioliaei A1 ; Larijani B1 ; Mahdavi M1
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism, Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713119, Iran

Source: ChemistrySelect Published:2023


Abstract

Cyclopropanols, due to their particular chemistry, can participate in various synthetic reactions with retention or cleavage of the strained three-membered ring. Direct cross-coupling ring-opening reaction of such molecules access to organic compounds, such as ketones has great importance in medicinal chemistry and material sciences. Hence, the coupling reaction/cyclization ring-opening of cyclopropanols for constructing new valuable molecules in the presence of a transition metal catalyst or under metal-free conditions is described in this context. The features of the reactions are discussed, and the mechanisms of the challenging reactions are highlighted. © 2023 Wiley-VCH GmbH.